Navigation Links
UCLA stem cell researchers uncover mechanism that regulates human pluripotent stem cell metabolism
Date:11/15/2011

nhibiting the stem cell's ability to respire as a method for generating energy.

As pluripotent stem cells were driven to develop into mature cell types, UCP2 expression was shut off, allowing respiration substrates to enter the mitochondria for energy generation, switching the cells from glycolysis to oxidative phosphorylation. Manipulating UCP2 expression, by keeping it switched on in differentiating cells, disturbed their maturation, a finding that could make them unsuitable for clinical use and also pointing to the importance of properly functioning metabolism for generating safe, high quality cells.

Teitell and his team confirmed these findings in both human embryonic stem cells and in induced pluripotent stem cells, which are mature body cells that are genetically reprogrammed to have similar abilities and attributes as the pluripotent embryonic stem cells.

"A main question that evolved during the study was whether it was the process of pluripotent stem cell differentiation that was altering the pattern of metabolism, or was it the change in the pattern of metabolism that altered the process of differentiation, a typical chicken-or-the-egg question," Teitell said. "We over-expressed UCP2 in the stem cells and showed that metabolism patterns changed before markers of pluripotency or cell maturation changed, indicating that changes in metabolism affect changes in differentiation and not the other way around, at least for UCP2. This was important, to show causation for metabolic changes in driving the process of cell differentiation. However, it still leaves open the key question of exactly how manipulating cell metabolism controls cell differentiation, a question we are working hard to address."

Since metabolism in pluripotent stem cells and cancer cells appear quite similar, Teitell said the finding could potentially be used to target UCP2 in malignant tumors that express it, of which there are many. Silencing UCP2 could force
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Ben-Gurion University of the Negev researchers achieve male fertility breakthrough
2. Canadian researchers find potential new leukemia treatment with old antibiotic drug
3. FDA funds Rochester researchers to give chronic and acute pain clinical trials a makeover
4. Jefferson researchers study outcomes of carotid artery stenting following prior carotid procedure
5. Researchers gain insight into 100-year-old Haber-Bbosch process
6. New funding will help researchers learn how preschoolers move, battle early child obesity
7. Pitt researchers using mathematics to target Parkinsons disease symptoms
8. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
9. Lose the fat and improve the gums, CWRU dental researchers find
10. Researchers identify diabetes link to cognitive impairment in older adults
11. UGA researchers develop first mouse model to study important aspect of Alzheimer’s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... RB SEO Services, a well-recognized internet marketing ... businesses. , RBSEO Services knows this very well that ... optimization service. So, the company has introduced this service, ... , On being asked about the service, a senior ... SEO service because many small businesses expressed their inability ...
(Date:8/30/2014)... 2014 After offering hyperbaric oxygen ... the past several years, Dr. Roy Schmidt and ... announced a scholarship program for veterans who have ... meeting held this summer to discuss veterans’ needs ... have shed light on the large number of ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Seniors Guide, the ... recently that focus on Alzheimer’s Disease, Dementia, and Memory ... to the public of being diagnosed with the Alzheimer’s, inspired ... movie, “I’ll Be Me”. The movie, out on October ... focusing on his diagnosis of the disease – which inspires ...
(Date:8/30/2014)... Grand Rapids, MI (PRWEB) August 30, 2014 ... Michigan residents, Forefront Dermatology is expanding with the addition ... Mich. Dr. David Hammond who has provided leading-edge skin ... practice with Forefront Dermatology. , “As a doctor, ... care they deserve. Through partnering with Forefront Dermatology, I’m ...
(Date:8/30/2014)... AZ (PRWEB) August 30, 2014 Hastings ... personal injury attorneys located throughout Arizona is pleased to ... This is one specific example among many cases where ... clients are able to retain a greater portion of ... after case that providing a positive solution for Arizona ...
Breaking Medicine News(10 mins):Health News:RBSEO Services Introduces Low Cost SEO Service for Small Businesses 2Health News:Tennessee Hyperbaric Center Offering HBOT Scholarships to Veterans 2Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2Health News:Expanding Care at the Forefront of Dermatology 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2
... novel catheter technique for patching holes in the heart ... surgery altogether and others to regain enough strength ... according to a study reported at the 30th Annual ... Interventions, May 912, 2007, in Orlando, FL. ...
... she has a date. ,"We call them dates," she said ... ,Anxiously, she brushes her long dark hair off her slight shoulders ... Kenyatta, 22, was born a male, her large hands and Adam's apple ... is little to suggest that she wasn't a girl her entire life. ...
... a mark of highest recognition for the meritorious services of ... ,Till the year 1989, 31 awards were allocated (18 ... Lady Health Visitors). ,,National Awards for Nurses ... meritorious services of the nurses and nursing profession in the ...
... Britney Spears' come-back album will supposedly not talk about the ... instead "celebrate womanhood". ,Nate Hills, who collaborated on ... to be about Spears venting her problems, reports dailysnack.com. ... out'. She said she deals with that in another way. She ...
... data reported at the 30th Annual Scientific Sessions of ... May 912, 2007, in Orlando, FL, will offer clues ... is vying for a place in the treatment of ... randomly assigned 436 patients treated at 30 medical centers ...
... she chants as she decides what to do with her ... used by many Buddhists celebrities including Tina Turner to help ... wrote on her website: "I chanted two hours tonight and ... ,She is deciding between having a private sale or an ...
Cached Medicine News:Health News:Novel Catheter Technique Successfully Patches Holes in the Heart 2Health News:Novel Catheter Technique Successfully Patches Holes in the Heart 3Health News:Making Change: The Cost of Being Transgender 2Health News:Making Change: The Cost of Being Transgender 3Health News:Making Change: The Cost of Being Transgender 4Health News:Making Change: The Cost of Being Transgender 5Health News:Florence Nightingales of India Honored by President 2
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "Global Multiple Sclerosis Drugs Market 2014-2018" ... is a chronic, inflammatory medical condition that results in ... damaged because of an abnormal response by the immune ... (CNS). It is a potentially debilitating disease in which ...
(Date:8/29/2014)... 29, 2014  Abaxis, Inc. (NasdaqGS: ABAX ... and consumables to the medical, research and veterinary markets, ... Chief Executive Officer, will present at the CL King ... Tuesday, September 9, 2014 at 12:30 p.m. ET. The ... Hotel in New York City . ...
(Date:8/29/2014)... MENLO PARK, Calif. , Aug. 29, 2014 /PR ... ("DelMar" "the Company") today announced the filing of June ... changed its fiscal year end to June 30th in ... stock on a national securities exchange in the timeliest ... with the United States Securities Exchange Commission can be ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5
... NEW YORK, Sept. 6, 2011 ... research report is available in its ... Contract Research Organizations (CRO) - Asia-Pacific, ... Benefit from Rising Financial and Regulatory ...
... BLUE BELL, Pa., Sept. 6, 2011 Inovio Pharmaceuticals, ... in the development of therapeutic and preventive vaccines against ... board with the appointment of two prominent leaders in ... advisory board are Dr. Thomas S. Edgington, Emeritus Professor ...
Cached Medicine Technology:Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 2Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 3Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 4Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 5Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 6Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 7Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 8Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 9Top 20 Contract Research Organizations (CRO) - Asia-Pacific, Especially India and China, Positioned to Benefit from Rising Financial and Regulatory Pressures in Western Pharmaceutical Markets 10Inovio Pharmaceuticals Adds Two Medical Innovators to Its Scientific Advisory Board 2Inovio Pharmaceuticals Adds Two Medical Innovators to Its Scientific Advisory Board 3Inovio Pharmaceuticals Adds Two Medical Innovators to Its Scientific Advisory Board 4Inovio Pharmaceuticals Adds Two Medical Innovators to Its Scientific Advisory Board 5
... to having been designed exclusively for vascular treatments, ... the Smartepil range which ensures fast amortisation of ... systems, it can be fitted with a polarised ... the target to be treated as well as ...
... SmartLite Derm is a KTP laser, ... of 532 nm (frequency doubled Nd:YAG) for ... by the comfortable color LCD Touch-screen. ... available are 0.3, 0.5, 0.7 and 1.0 ...
... a new and powerful instrument for ... system (MEL @308 nm - UVB) ... vitiligo. Designed to treat recalcitrant plaques, ... exposure of extensive lesions without irradiating ...
... a CO2 laser system with CW intensities ... dealing with all therapeutic application in modern ... medium-to-high intensities in super-pulsed mode, designed for ... It is also capable of supplying soft ...
Medicine Products: