Navigation Links
UCLA scientists report link between traumatic brain injury, post-traumatic stress disorder
Date:2/15/2012

UCLA life scientists and their colleagues have provided the first evidence of a causal link between traumatic brain injury and an increased susceptibility to post-traumatic stress disorder.

Their new study, published Feb. 15 in the in the journal Biological Psychology, also suggests that people who suffer even a mild traumatic brain injury are more likely to develop an anxiety disorder and should take precautions to avoid stressful situations for at least some period of time.

The motivation behind the study, which was conducted in rats, was the observed correlation of traumatic brain injury, or TBI, and PTSD, particularly in military veterans returning from service overseas, said Michael Fanselow, a UCLA professor of psychology and the senior author of the study.

The reasons for this correlation are unknown. It could be simply that the events that cause brain injury are also very frightening and that the link between TBI and PTSD could be merely incidental. Fanselow and his colleagues, however, hypothesized that the two "could be linked in a more mechanistic way."

Using procedures to separate the physical and emotional traumas, the scientists trained the rats using "fear conditioning" techniques two days after they experienced a concussive brain trauma ensuring the brain injury and the experience of fear occurred on different days.

"We found that the rats with the earlier TBI acquired more fear than control rats (without TBI)," said Fanselow, a member of UCLA's Brain Research Institute. "Something about the brain injury rendered them more susceptible to acquiring an inappropriately strong fear. It was as if the injury primed the brain for learning to be afraid."

To learn why this occurred, the researchers analyzed a small piece of brain tissue, the amygdala, which is the brain's critical hub for fear learning.

"We found that there are significantly more receptors for excitatory neurotransmitters that promote learning," said Maxine Reger, a UCLA graduate student of psychology in Fanselow's laboratory and the lead author of the study.

"This finding suggests that brain injury leaves the amygdala in a more excitable state that readies it for acquiring potent fear," Fanselow said.

The research was funded by the National Institutes of Health, the U.S. Department of Defense and the UCLA Brain Injury Research Center.

Co-authors of the study were David Hovda, a professor of neurosurgery and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA and director of the UCLA Brain Injury Research Center; Andrew Poulos, a postdoctoral fellow in Fanselow's laboratory; Floyd Buen, a former graduate student in Hovda's laboratory; and Christopher Giza, an associate professor of neurosurgery at the Geffen School of Medicine.

The research was a collaboration between Fanselow's laboratory, which studies neural mechanisms of anxiety disorders, and Hovda's laboratory, which investigates brain injury.

"One of UCLA's great strengths is the spirit of collaboration that allows scientists from very different departments to combine their very different expertises to answer important but difficult questions," Fanselow said.


'/>"/>
Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Scientists make strides toward fixing infant hearts
2. Scripps research scientists demonstrate effective new biopsy in a blood test to detect cancer
3. Scientists May Be Closer to Developing Red Wine Drug
4. Scientists Use Brain Waves to Eavesdrop on the Mind
5. Scripps research scientists illuminate cancer cells survival strategy
6. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
7. Gladstone scientists identify genetic mechanism linked to congenital heart disease
8. Scientists Agree to Delay Controversial Bird Flu Research
9. Scientists shed new light on link between killer cells and diabetes
10. NIH scientists identify novel approach to view inner workings of viruses
11. UNC scientists collaborate to find first major genetic mutation associated with hereditary prostate cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... In honor of National Physical Fitness and Sports ... who share their fitness journey on social media. , The foot care company, ... a $100 product voucher each week during May to one winner. , “Whether the ...
(Date:5/2/2016)... ... 02, 2016 , ... East Los Angeles dentist , Dr. Ramin Assili, ... Assili to receive any dental extraction treatment for $40 off the regular price. This ... With the lower price, patients can more easily afford extractions to eliminate teeth that ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Rassouli, dentist ... and cognitive decline. According to the research, which was published in the “Journal of ... cognitive decline, and about 5.4 million Americans have Alzheimer’s disease. The study found that ...
(Date:5/2/2016)... ... May 02, 2016 , ... Pregnancy Awareness Month offers a great time ... , “If you are ready to have a baby, it’s best to get ... Journal Babies is your Personal Conception & Pregnancy Organizer, written for women who plan ...
(Date:5/2/2016)... ... ... Kulbersh of Carolina Facial Plastics isn’t surprised that Charlotte, NC, the city where he and ... Cities with the Highest Plastic Rates .” The other cities that made the list ... a survey by RealSelf and combining that data with the number of board-certified ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... -- Automation is one of the best ... growing demands for productivity in speed, accuracy, throughput and ... already adept of a wide range of functions that ... Instrumentation continues to evolve, and is poised to tackle ... years ago. Originally used mostly by the big pharmaceutical ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... April 28, 2016  Marking its one year ... and ovarian cancer risk test, Color Genomics ... genes that highly impact the most common hereditary ... the Color Test analyzes hereditary cancer risks for ... uterine cancers. The Color Test is physician ordered ...
Breaking Medicine Technology: