Navigation Links
UCLA scientists prove endothelial cells give rise to blood stem cells
Date:12/3/2008

and platelets. If blood stem cells can be gown outside the body from endothelial cells and only self-renew, or make more of their own kind, researchers may one day be able to reprogram blood vessel cells to produce blood stem cells to replace the bone marrow in transplants or the mutated blood cells that result in diseases like leukemia.

"We found that endothelial cells are capable of making blood stem cells within embryonic areas that prevent differentiation into other lineages," Zovein said. "In trying to understand how blood stem cells arise from the endothelium, we may learn enough to be able to grow pure, designer blood stem cells outside the human body."

For example, researchers may some day be able to take a blood vessel from a patient and grow blood stem cells specific to that patient, which could be used for bone marrow transplantation. Since the blood stem cells originated from the patient, there would be no need to find a matching donor to provide the marrow. The cells also could be used to replace diseased cells that result in cancer, providing a new way to treat malignancies such as leukemia.

The creation of blood stem cells by endothelial cells occurs at a specific time in embryonic development and researchers want to know what takes place biologically during that period, what specific cell signaling pathways are sending the messages to make blood stem cells. Iruela-Arispe and her team hope to mimic the embryonic environment in the lab to create blood cells that don't differentiate.

"Next we need to understand what signaling mechanisms are at work that allow endothelial cells to make blood stem cells," Iruela-Arispe said. "We need to find out how we can program the endothelial cells to make blood stem cells, what's important in the embryonic blood vessel wall that allows for this phenomenon and whether we can reprogram adult blood vessels to do the same thing."

While this study was done in mouse models
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
2. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
3. Carnegie Mellon scientists offer explanation for face blindness
4. Scientists ID Uterine Muscle Switch for Contractions
5. The Honorable Edward M. Kennedy, Scientists Mina J. Bissell and Susan Band Horwitz, and Philanthropist Jon M. Huntsman to Receive American Cancer Society Highest Honor for Outstanding Contributions to Cancer Fight
6. Scientists honored for contributions to cancer fight
7. United BioSource Scientists, FDA, and Other Industry Leaders Present to Risk Management and Drug Safety Summit
8. Scientists exploring new compounds to target muscular dystrophy
9. Portuguese scientists discover new mechanism that regulates formation of blood vessels
10. UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
11. Leading Scientists From Around the World Headed to Kansas for Symposium on Combating Deadly Infectious Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA scientists prove endothelial cells give rise to blood stem cells
(Date:7/28/2014)... divide unless there is enough oxygen present to support ... types circumvent this rule. Researchers at The Johns Hopkins ... cells, warning signals, enabling cancers to continue to divide ... the researchers found that lysosomes the cell,s protein ... also uncovered new evidence that certain drugs can halt ...
(Date:7/28/2014)... Parker Waichman LLP, a personal injury law firm ... heroes of 9/11 are never forgotten, comments that the September ... According to a VCF message dated July 3, ... or before October 12, 2012 must file a Registration Form ... who were allegedly injured by the toxic dust cloud that ...
(Date:7/28/2014)... York, NY (PRWEB) July 28, 2014 ... literacy organization that has donated more than 200,000 books ... in 2001, announces the launch of Brooke’s Cooks, a ... values, while encouraging healthy living among at-risk children and ... Cooks will include a series of nutrition information workshops, ...
(Date:7/28/2014)... Utah (PRWEB) July 28, 2014 Bariatric ... and drinks, announced that it will be introducing three ... of products this summer. The additional flavors include: , ... pure taste-free protein , Inspire Pomegranate Razz Berry -­ ... flavor of soft-serve vanilla cone , Bariatric Eating's ...
(Date:7/28/2014)... one of two dopamine-producing regions in the brain was ... isoflurane or propofol. In the August issue of ... report that rats anesthetized with continuous doses of either ... up in response to electrical stimulation delivered to the ... major dopamine-releasing area, the substantia nigra, did not induce ...
Breaking Medicine News(10 mins):Health News:Cell's recycling center implicated in division decisions 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2
... By Steven Reinberg HealthDay Reporter , ... have prostate cancer that,s considered "intermediate risk," radiation plus ... a new study finds. This combination of treatments, ... prostate cancer or advanced disease, the researchers said. Men ...
... cardiologists are prone to misinterpreting electrocardiograms when using ... heart defects that could make exercising perilous, according ... School of Medicine and Lucile Packard Children,s Hospital. ... acumen of pediatric cardiologists from several health-care institutions ...
... HealthDay Reporter , WEDNESDAY, July 13 (HealthDay News) -- ... infection can significantly reduce the chance they will develop the ... is an extremely exciting finding for the field of HIV ... a University of Washington associate professor of global health. ...
... , WEDNESDAY, July 13 (HealthDay News) -- Rural workers are often ... loved one and their jobs, researchers report. According to ... University of New Hampshire, people who work in rural communities have ... lost pay or lost jobs and caring for themselves or a ...
... control, growing wildly and breaking all the rules of orderly ... is a balance between a cancer cell,s revved-up metabolism and ... depends on a hyperactive metabolism to fuel its rapid growth, ... reactive oxygen species (ROS) generated by such high metabolic demand. ...
... WEDNESDAY, July 13 (HealthDay News) -- Wearing flip-flops and baseball ... warns. "Most skin cancers occur on the parts of ... Rebecca Tung, director of the dermatology division at Loyola University ... release. "The problem with flip-flops and baseball caps is ...
Cached Medicine News:Health News:For Some Prostate Cancer Patients, Combo Treatment Improves Survival 2Health News:For Some Prostate Cancer Patients, Combo Treatment Improves Survival 3Health News:Pediatric cardiologists not always accurate in interpreting ECG results for young athletes 2Health News:Pediatric cardiologists not always accurate in interpreting ECG results for young athletes 3Health News:Drugs May Prevent HIV Spread Among Heterosexuals 2Health News:Drugs May Prevent HIV Spread Among Heterosexuals 3Health News:Rural Workers Often Lack Access to Sick Leave 2Health News:Taking out a cancer's co-dependency 2Health News:Taking out a cancer's co-dependency 3Health News:Flip-Flops, Baseball Caps May Raise Risk of Skin Cancer 2
(Date:7/28/2014)... July 28, 2014 Concord Medical Services Holdings ... CCM ), a leading specialty hospital management solution provider ... diagnostic imaging centers in China , ... of Directors declared a special cash dividend of US$0.30 ... ("ADS")) on the Company,s outstanding ordinary shares. The total ...
(Date:7/28/2014)... July 28, 2014 ... 2,5 Millionen £ investiert hat, um die ... Gesundheits-, Pharma- und Logistikbranche zu erfüllen. Albion ...      (Photo: http://photos.prnewswire.com/prnh/20140728/697982 ) ... OmPrompt sein beschleunigtes Wachstum mit Investitionen in ...
(Date:7/28/2014)... NEW PROVIDENCE, N.J. , July 28, 2014 /PRNewswire/ ... meet with Linde,s Healthcare division experts at the ... at McCormick Place in Chicago, Illinois ... nothing less than complete confidence in a reliable medical ... Segment manager. "Linde understands the importance of this critical ...
Breaking Medicine Technology:Concord Medical Declares Special Dividend 2OmPrompt erhält Finanzierung für Marktexpansion von Kundenautomatisierungsmanagement 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
... Ill. and LONDON, Sept. 23 Following today’s announcements ... the European Medicines Agency (EMA) for rosiglitazone in the ... Takeda Pharmaceuticals Europe Limited (“Takeda”) underscore the company’s commitment ... and to the millions of people living with type ...
... Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two ... of 1,800 Real-World Patients Compared XIENCE V to the Newer-Generation TAXUS® Liberte®,-- ... Performance in Key Safety and Efficacy... -- ABBOTT PARK, Ill., Sept. 23 ... ...
Cached Medicine Technology:Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 2Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 3Takeda Responds to Announcement about Suspension of Rosiglitazone Marketing Authorization in Europe and Restrictions in the U.S. 4Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 2Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 3Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 4Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 5Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 6Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 7Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 8Abbott's XIENCE V® Shows Continued Strong Performance in Key Safety and Efficacy Measures at Two Years in Investigator-Initiated COMPARE Trial 9
Binocular indirect ophthalmic lenses. General diagnosis & treatment....
Binocular indirect ophthalmic lenses. Ultra-High resolutions viewing of posterior pole....
... super series slit ... Variable retinal scanning ... fundus diagnostic capability, ... potential field of ...
Volk indirect lenses. Wide field retinal diagnosis & treatment....
Medicine Products: