Navigation Links
UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
Date:11/14/2008

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women.

The pathway regulates how cells identify and destroy proteins and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells degrade the tumor suppressor gene p27 by making a new type of proteasome targeting complex. The gene p27 is one of a handful of proteins that are expressed in normal cells and act to prevent rapid cell growth, which is indicative of cancer. Beyond chemotherapy, no specific therapeutic target has been identified for this sub-type of cancer, found in between 12 to 15 percent of breast cancers in the general population and up to 25 percent of cases in African American women.

"The mortality rates in this subgroup of cancer are very high," said Tim Lane, senior author of the paper and a researcher at UCLA's Jonsson Comprehensive Cancer Center. "The possibility that this new proteasome targeting complex might provide targets for therapeutic intervention is a completely new area for breast cancer research."

The research, done in animal models and human breast cancer cell lines, is published in the Nov. 15 issue of the journal Genes and Development.

Scientists have identified five to seven different sub-types of breast cancer. Basal-like breast cancers currently are among the most difficult to treat.

Targeted therapeutics are available for several sub-types. Women with HER-2 positive breast cancers can receive Herceptin, which when paired with chemotherapy extends disease-free survival by more than 50 percent. HER-2 positive women used to have the worst prognoses before Herceptin was developed. They now have the best prognoses because the drug targets what's broken in the cancer cell that is driving the disease. Another sub-type includes women with Estrogen
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2804
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 01, 2014 On Monday, June 30th, ... User Symposium in San Francisco, CA. Now in its ... JW Marriott Union Square hotel. , “We are excited ... to speed with ACA compliance issues,” Quirk Healthcare Foundation ... symposium provides attendees guidance with NextGen implementation and use, ...
(Date:8/1/2014)... Alan Mozes HealthDay Reporter ... country, barbershops serve as a time-honored destination for a good ... whether barbershops might also be the spot to tackle an ... In a novel partnership, the U.S. Centers for Disease ... Health (MSDH), enlisted the help of barbershop staff to both ...
(Date:8/1/2014)... The North America Endpoint Security Market report defines and ... with analysis and forecast of revenue. This market is ... to $4.77 billion by 2019, at a CAGR of ... TOC of the North America Endpoint Security Market report ... It also provides a glimpse of the segmentation in ...
(Date:8/1/2014)... 1, 2014 The Cardiovascular Research Foundation (CRF) ... investigations that will be presented at next month,s ... the world,s premier educational meeting specializing in interventional ... 17, 2014 at the Walter E. Washington Convention ... presented at TCT often direct the course of ...
(Date:8/1/2014)... NY (PRWEB) August 01, 2014 ... The company develops biomarkers. Its products include CytoSure ... ISCA +SNP Array, CytoSure ISCA UPD array, CytoSure ... v2 array. OGT offers services, such as targeted ... RNA-Seq service, miRNA analysis, gene expression analysis, cytosure ...
Breaking Medicine News(10 mins):Health News:Quirk Healthcare Foundation Hosts Fifth Annual California NextGen User Symposium and Launches First Annual Florida NextGen User Symposium 2Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 2Health News:Barbershops Join Fight Against High Blood Pressure in Black Men 3Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 4Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 2Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 3Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 4Health News:Oxford Gene Technology Market Size, Share, Analysis, Trends and Forecasts 2014 2Health News:Oxford Gene Technology Market Size, Share, Analysis, Trends and Forecasts 2014 3
... SALAAM, Tanzania, April 25 Today is a,great day for ... and a day to,celebrate. We celebrate because of the possibilities ... today by the United,Nations Secretary General His Excellency Ban Ki-Moon, ... initiative is implemented to the,letter, millions of lives will be ...
... Inc. (NYSE:,NTY) (http://www.NBTY.com ), a leading global manufacturer ... web cast the,presentation by Harvey Kamil, President and Chief ... And Restaurant Conference in,New York on Tuesday, April 29, ... cast live on the Company Web,site, http://www.nbty.com ...
... (Nasdaq: THOR ), a world leader in ... restore failing hearts,today announced that it will report ... 2008 on Thursday, May 1., The company ... financial,results and operating activities to all interested parties ...
... and who,s telling the truth , , FRIDAY, April 25 ... window into the soul, but scientists have been reporting ... imperceptible facial expressions -- tell the real story of ... that people have a lot more trouble hiding their ...
... and reduced risk of recurrence during tuberculosis chemotherapy, according ... of The Journal of Infectious Diseases, now available online. ... common before the advent of anti-TB drugs, is no ... low-income countries even though poor nutrition impairs the immune ...
... Inc.,(Nasdaq: SMBL ) will hold its annual meeting ... 2008, at the Teaneck Marriott at Glenpointe, 100,Frank W. ... the close of business on April 2, 2008, are ... come before the meeting., About Smart Balance Inc., ...
Cached Medicine News:Health News:Statement by H.E. Jakaya Mrisho Kikwete, President of the United Republic of Tanzania, and Chairman of the African Union, in Response to UN-SG Call to Action on Malaria 2Health News:NBTY to Webcast Presentation at Lehman Brothers 11th Annual Retail and Restaurant Conference 2Health News:Thoratec Schedules First Quarter 2008 Conference Call, Webcast 2Health News:Fleeting Facial Expressions Reveal Deep Secrets 2Health News:Fleeting Facial Expressions Reveal Deep Secrets 3Health News:Study shows common vitamin and other micronutrient supplements reduce risks of TB recurrence 2
(Date:8/1/2014)... , Aug. 1, 2014 MGC Diagnostics ... company, announced today that it has completed its ... of cardiorespiratory diagnostic products based in Sorinnes, ... served the European cardiorespiratory diagnostics market since 1977. ... of approximately €4.7 million ($6.3 million) and incurred ...
(Date:8/1/2014)... 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: DYAI), ... are used to develop, manufacture and sell enzymes and ... industrial enzyme industries, announced today that it will report ... 30, 2014 after market close on Thursday, August 14, ... at 5:00 p.m. Eastern Time to discuss those results. ...
(Date:7/31/2014)... SAN DIEGO , July 31, 2014  Sorrento Therapeutics, ... death of Mr. Amar Singh , Chief Business Officer ... of apparent natural causes on July 30. "Sorrento ... dear friend and colleague. Our immediate thoughts go to Amar,s ... President and Chief Executive Officer. Mr. Singh ...
Breaking Medicine Technology:MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3Sorrento Announces the Unexpected Death of its Chief Business Officer 2
... 2, 2012  Solos Endoscopy, Inc. (OTCPK: SNDY) is pleased ... the month of February, its Food and Drug Administration ... NAI (No Action Indicated) for the inspection. ... perform unannounced inspections for medical device manufacturers and the ...
... N.J., March 2, 2012 Watson Pharmaceuticals, Inc. ... Watson has launched an authorized generic version of ... part of an agreement with Abbott Laboratories. Watson ... indicated for use in the prevention of endometrial ...
Cached Medicine Technology:Solos Endoscopy, Inc. Successfully Completes Level I FDA Inspection 2Watson Launches Generic PROMETRIUM(R) 2
... For Excellent Drainage PLUS Greater Patient ... BLAKE Drains are white, radiopaque silicone drains ... a solid core center. Their other components ... extension tubing and an adapter. The drains ...
Used for percutaneous placement of laparoscopic surgical instruments. Check-Flo® valve provides a secure seal around the instruments to be introduced. Supplied sterile in peel-open packages. Inte...
Used for internal biliary drainage. Supplied sterile in peel-open packages. Intended for one-time use....
Used for common bile duct exploration. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: