Navigation Links
UCLA scientists create army of tumor-fighting immune cells and watch as they attack cancer
Date:7/12/2010

Researchers at UCLA's Jonsson Comprehensive Cancer Center created a large, well armed battalion of tumor-seeking immune system cells and watched, in real time using Positron Emission Tomography (PET), as the special forces traveled throughout the body to locate and attack dangerous melanomas.

The gene therapy work, done with melanomas grown in mice, employed a crippled HIV-like virus to serve as a vehicle to arm the lymphocytes with T cell receptors, which caused the lymphocytes to become specific killers of cancerous cells. A reporter gene, which glows "hot" during PET scanning, also was inserted into the cells so researchers could track the genetically engineered lymphocytes after they were injected into the blood stream, made their way to the lungs and lymph nodes and then specifically homed in on the tumors wherever they were located within the body.

"We're trying to genetically engineer the immune system to become a cancer killer and then image how the immune system operates at the same time," said Dr. Antoni Ribas, an associate professor of hematology/oncology, a researcher at UCLA's Jonsson Comprehensive Cancer Center and the senior author of the study. "We knew this approach of arming the lymphocytes with T cell receptors showed significant anti-tumor activity based on studies in humans. Now, by tracking the immune system's reaction to cancer and imaging it in real time, we can project how the same process that succeeded in mice might behave in people."

The study is published July 12, 2010 in the early online edition of the journal Proceedings of the National Academy of Sciences.

"The novelty of our work is that we were able to pack together the cancer specific T cell receptor and the PET reporter genes in a single vector and use it in mice with an intact immune system that closely resembles what we would see in real patients," said Dr. Richard Koya, an assistant professor of surgical oncology at UCLA's Dav
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists reprogram triple-negative breast cancer cells to respond to tamoxifen
2. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
3. Scientists design new delivery device for gene therapy
4. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
5. Scientists find link between estrogen metabolism pathway and breast cancer risk
6. Scientists Spot Gene Variants That Predict Longevity
7. Damon Runyon and Doris Duke Foundations announce partnership to support physician-scientists
8. Scripps Research scientists share $2 million in Florida state research grants
9. Melanoma-initiating cell identified by Stanford scientists
10. Scientists Fashion New Lung for Rats
11. Scientists Tease Out Links Between Diabetes, Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2015)... BC (PRWEB) March 29, 2015 Pro ... that the company will now provide qualified HVAC technicians ... maintain their heat pumps and related systems throughout Vancouver, ... “Like furnaces and air conditioners, heat pumps require regular ... pump, experts such as BC Hydro strongly suggest you ...
(Date:3/29/2015)... Elfster.com, the top-rated Secret Santa generator, ... plans to publicize its gift exchange generator technology and ... as the leader in Secret Santa online gift exchanges, ... markets can see the opportunities as well. , "We ... Peter Imburg, CEO of Elster.com. "With Christmas and Valentine’s ...
(Date:3/29/2015)... Metamora, MI. (PRWEB) March 29, 2015 ... Hospital , offers comprehensive endometriosis treatment. Secondary to ... that area a closer hospital option. They continue ... and McLaren Oakland. , Endometriosis is often ... the inside of the uterus (the endometrium) grows outside ...
(Date:3/29/2015)... Karnataka (PRWEB) March 30, 2015 ... receipt of the coveted NABH Accreditation on 11th ... Board for Hospitals and Healthcare Providers) comes as ... quality care standards of Telerad RxDx., With Telerad ... to be accredited for NABH, marks a major ...
(Date:3/29/2015)... 2015 The Claudia Cohen Research ... announce today that Dr. Beth Y. Karlan has ... Cohen Research Foundation Prize for Outstanding Gynecologic Researcher. The ... Gynecologic Oncology 46th Annual Meeting on Women's Cancer in ... Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer ...
Breaking Medicine News(10 mins):Health News:Pro Ace Care Now Provides Qualified HVAC Technicians for Heat Pump Maintenance 2Health News:Gift Exchange Generator Promotion Achieves Early Success, Announces Elfster 2Health News:Women's Excellence Affiliates with Beaumont Hospital, Treats Endometriosis 2Health News:NABH Accreditation for Telerad RxDx – Whitefield. 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 3Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 4
... , WASHINGTON, Dec. 8 The National Business Group on ... employers, announced today that Sally Welborn, Senior Vice President of ... Directors, effective immediately. , "We are thrilled to announce Sally,s ... Senior Vice President of Human Resources at Coca-Cola Enterprises ...
... 8 Dr. Rong Zhang, a researcher at the Institute ... Dallas, has been awarded a four-year grant from the National ... brain function as people age. , "There are many mysteries ... in those with mild cognitive impairment, which leads to Alzheimer,s ...
... , DURHAM, N.C., Dec. 8 ... criticizing the PGA Tour,s one year suspension, under its "Anti-Doping" policy, ... Memphis, Tennessee, who last month became the first and only player ... Barron for doping is dopey," says Robert S. Whitehead, President & ...
... - May Set Stage for Treating Brain Damage in People - ... that feeding amino acids to brain-injured animals restores their cognitive abilities ... cognitive impairments suffered by people with traumatic brain injuries. , "We ... a proper balance of neurochemicals in the injured part of the ...
... Honor for Innovation and Performance Excellence , ... U.S. Department of Commerce have announced that a Department ... is the recipient of the 2009 Malcolm Baldrige National ... , "This prestigious recognition is a demonstration of VA,s ...
... in hormone replacement therapy doesn,t fully explain the 7% ... -- The incidence of breast cancer in the United ... only part of that decrease can be attributed to ... women, researchers say. , HRT use declined after the ...
Cached Medicine News:Health News:National Business Group on Health Elects Sally Welborn, Walmart Executive, to Board of Directors 2Health News:Dallas Researcher Aims to Unlock Mysteries of Alzheimer's Disease 2Health News:PGA Tour's Suspension of Doug Barron For Doping Is 'Dopey,' Says Pharmaceutical Company CEO 2Health News:PGA Tour's Suspension of Doug Barron For Doping Is 'Dopey,' Says Pharmaceutical Company CEO 3Health News:PGA Tour's Suspension of Doug Barron For Doping Is 'Dopey,' Says Pharmaceutical Company CEO 4Health News:With Amino Acid Diet, Mice Improve After Brain Injury 2Health News:With Amino Acid Diet, Mice Improve After Brain Injury 3Health News:VA Research Center in Albuquerque Receives Baldrige Award 2Health News:Breast Cancer Decline Only Partly Due to HRT 2
(Date:3/30/2015)... March 30, 2015  BioDelivery Sciences International, Inc. ... efficacy endpoint in the Phase 3 clinical study ... the treatment of painful diabetic neuropathy did not ... statistically significant improvement over placebo.  In addition, a ... The results of this trial provide data that ...
(Date:3/27/2015)... -- BioCorRx, Inc. ( BICX ... is a healthcare solutions organization, which focuses solely on addiction ... in the U.S. alone. The Company created a unique treatment ... specially compounded form for outpatient surgical implantation. The Company has ... New Zealand ) to the specially formulated Naltrexone ...
(Date:3/27/2015)... Object recognition technology has a unique and ... The VelaSense ® mobile platform incorporates ... productive and fulfilling lives. VelaSense ® will now ... identify objects from a one million object database, that ... databases for personal use. Visus Technology ...
Breaking Medicine Technology:BioDelivery Sciences Announces Primary Endpoint in Phase 3 Study of Clonidine Topical Gel for Painful Diabetic Neuropathy Not Met, Though Encouraging Results Support Continued Development 2BioDelivery Sciences Announces Primary Endpoint in Phase 3 Study of Clonidine Topical Gel for Painful Diabetic Neuropathy Not Met, Though Encouraging Results Support Continued Development 3BioDelivery Sciences Announces Primary Endpoint in Phase 3 Study of Clonidine Topical Gel for Painful Diabetic Neuropathy Not Met, Though Encouraging Results Support Continued Development 4BioDelivery Sciences Announces Primary Endpoint in Phase 3 Study of Clonidine Topical Gel for Painful Diabetic Neuropathy Not Met, Though Encouraging Results Support Continued Development 5Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2VelaSense Object Recognition Technology for the Blind was unveiled at Baruch College's CCVIP 8th Annual Conference 2
Provides a perfect ring reference to the corneal surface, most useful for the wound closure evaluation. Shaft angled 35 degrees. Round knurled handle with dull finish....
Stainless steel tray for sterilizing instruments....
Diamond knife tray with silicone inserts to securely hold the diamond knife....
Lance shaped gently curved tip. Flat serrated handle with polished finish....
Medicine Products: