Navigation Links
UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
Date:12/23/2010

The cell signaling pathway known as Wnt, commonly activated in cancers, causes internal membranes within a healthy cell to imprison an enzyme that is vital in degrading proteins, preventing the enzyme from doing its job and affecting the stability of many proteins within the cell, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

The finding is important because sequestering the enzyme, Glycogen Synthase Kinase 3 (GSK3), results in the stabilization of proteins in the cell, at least one of which is known to be a key player in cancer, said Dr. Edward De Robertis, senior author of the study and a Jonsson Cancer Center scientist.

"Surprisingly, we found that the degradation of about 20 percent of proteins in the cell is triggered by the GSK3 enzyme," said De Robertis, who also is a Howard Hughes Medical Institute investigator. "That's a great many proteins and one of them, beta-Catenin, is known to cause cancer. We also know that Wnt signaling is activated in about 85 percent of colorectal cancers and other forms of cancer start with mutations that activate Wnt signaling. So, this finding could have ramifications for potential new treatments for cancer."

The study, a collaboration with cell biologist Dr. David D. Sabatini of New York University, appears in the Dec. 23, 2010 issue of the peer-reviewed journal Cell.

De Robertis said Wnt signaling requires inhibition of GSK3, but the enzyme sequestration mechanism was not known until now. The enzyme becomes imprisoned inside membrane-bounded organelles, known as multivesicular bodies, found within the cell cytoplasm.

"We knew these multivesicular bodies were involved in degradation of proteins, but that they had a role in how cells communicate with each other by switching on a signaling pathway was not known," De Robertis said. "This finding raises the possibility that other signaling pathways could operate through this sequestration mechan
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Mount Sinai researchers make major breakthrough in melanoma research
2. Penn researchers identify potential target for breast cancer therapy
3. Researchers Turn White Fat to Energy-Burning Brown Fat in Mice
4. Finnish researchers find a compound that prevents the growth of prostate cancer cells
5. Ben-Gurion U. researchers: High resistance rates among acute otitis media pathogens in children
6. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
7. Researchers discover new signaling pathway linked to inflammatory disease
8. UCI researchers find novel memory-enhancing mechanism in brain
9. Researchers make critical leukemia stem cell discovery
10. U-M researchers discover way to block neurodegeneration in an adult form of Fragile X syndrome
11. Leibniz Prize 2011: 10 researchers awarded €2.5 million ($3.3 million) each
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
(Date:8/31/2014)... MD (PRWEB) August 31, 2014 ... health records (EHR) software firm that focuses on ... practice success found a congruent commitment with the ... Sports . , “We create an environment that ... effortlessly, allowing more time with patients,” says Steven ...
(Date:8/31/2014)... This September, California Library Literacy ... celebrates 30 years of changing the lives of ... California’s Library Literacy Services has helped nearly a ... and write. , To mark the 30th anniversary ... launching a month-long awareness campaign titled “Together, California ...
(Date:8/31/2014)... Sunday 31 August 2014: Wine only protects against ... results from the In Vino Veritas (IVV) study presented ... the Czech Republic. , Professor Taborsky said: "This is ... and white wine on markers of atherosclerosis (1) in ... found that moderate wine drinking was only protective in ...
(Date:8/30/2014)... August 2014: A retrievable and repositionable transcatheter aortic ... world setting, according to research presented at ESC ... Germany. The direct flow medical (DFM) transcatheter aortic ... and has the potential to improve transcatheter aortic ... aortic stenosis. , Dr Pyxaras said: "TAVI is ...
(Date:8/30/2014)... Malden, MA (PRWEB) August 31, 2014 In ... ‘dog eat dog’ approach, Karma Web Group, LLC launches a ... iOS and Android the newly launched Ultimate Karma app is ... rewarded with new levels of play, the game pulls double-duty ... at the same time. , Designed to reward gamers for ...
Breaking Medicine News(10 mins):Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 2Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 3Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 4Health News:California Library Literacy Services Celebrates 30th Anniversary 2Health News:California Library Literacy Services Celebrates 30th Anniversary 3Health News:Wine only protects against CVD in people who exercise 2Health News:Retrievable transcatheter aortic valve effective and safe in real world setting 2Health News:Newly Launched Ultimate Karma App Elicits Happiness in Players and Encourages Moral Values 2
... , ... Plastic Surgeon Dr. Michael R. Macdonald announced the launch of a new plastic surgery ... plastic surgery patients who chronicle their cosmetic surgery experience through detailed daily accounts of ... ...
... safe amount of alcohol for women during this time, experts ... may have another reason to avoid drinking, with a new ... for a rare blood cancer in children. , The research, ... leukemia (AML), an often fatal blood cancer, increased by 56 ...
... choice when evaluating patients with foot drop (an inability or ... of the foot while taking a step), according to a ... in San Diego, CA. Ultrasound imaging is non-invasive and involves ... produce pictures of inside the body. Foot drop is ...
... As Drinking ... in encouraging everyone to play a role in keeping our water supplies and systems secure. ... Denver, CO (Vocus) ... (AWWA) joins water professionals across North America in encouraging everyone to play a role in ...
... ... , ... May 6, 2010 -- Phybridge Inc , a leading provider of IP telephony ... the Cool Vendors in Enterprise Communications Applications, 2010 report published March 31, 2010 by ...
... ... set…GO! Summer kicks off each year with the City of Laguna ... year, the event is expected to bring out more than 6,000 runners, ... Day – Monday May 31. Registration is available online at www.lagunahillshalfmarathon.com ...
Cached Medicine News:Health News:San Francisco Plastic Surgeon Releases Plastic Surgery Patient Recovery Blog 2Health News:Drinking While Pregnant Tied to Rare Leukemia in Offspring 2Health News:Drinking While Pregnant Tied to Rare Leukemia in Offspring 3Health News:Water Community Stresses Importance of Security During Drinking Water Week 2Health News:Phybridge Named "Cool Vendor" by Leading Analyst Firm 2Health News:City of Laguna Hills Announces Memorial Day Half Marathon and 5K 2
(Date:8/29/2014)... , Aug. 29, 2014  In part ... to leverage a hospital pharmacy as a strategic asset, ... national practice leader for Cardinal Health,s Innovation Delivery Solutions ... care can benefit both hospitals and patients. ... only one part of their job in a value-based ...
(Date:8/29/2014)... Pixcelldata, the innovative Irish developer ... a major new deal with Dutch based eX-Path, global ... Dr. Marius Nap . The announcement ... of Pathology which is taking placing between August 30th ... London where Pixcelldata will demonstrate its innovative ...
(Date:8/28/2014)... NEW YORK, Aug. 28, 2014 Reportlinker.com ... available in its catalogue: North America ... 2020 http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html ... Market Outlook to 2020 Summary GlobalData,s ... Devices Market Outlook to 2020", provides key market ...
Breaking Medicine Technology:Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16
... Monitor (PCM) and Central Station provide an ... extends the cardiac cath or electrophysiology lab ... and/or EP procedures, providing both physiomonitoring parameters ... either standalone or on its own network. ...
For the critical care environment, telemetry, emergency room and other monitoring areas....
DS 7600 Central Station...
... Gemini Family of infusion pumps ... a collective series of administration ... line offers a wide variety ... sets, each featuring the patented ...
Medicine Products: