Navigation Links
UCLA researchers identify brain cells responsible for keeping us awake
Date:11/3/2011

Bright light arouses us. Bright light makes it easier to stay awake. Very bright light not only arouses us but is known to have antidepressant effects. Conversely, dark rooms can make us sleepy. It's the reason some people use masks to make sure light doesn't wake them while they sleep.

Now researchers at UCLA have identified the group of neurons that mediates whether light arouses us or not. Jerome Siegel, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, and colleagues report in the current online edition of the Journal of Neuroscience that the cells necessary for a light-induced arousal response are located in the hypothalamus, an area at the base of the brain responsible for, among other things, control of the autonomic nervous system, body temperature, hunger, thirst, fatigue and sleep.

These cells release a neurotransmitter called hypocretin, Siegel said. The researchers compared mice with and without hypocretin and found that those who didn't have it were unable to stay awake in the light, while those who had it showed intense activation of these cells in the light but not while they were awake in the dark.

This same UCLA research group earlier determined that the loss of hypocretin was responsible for narcolepsy and the sleepiness associated with Parkinson's disease. But the neurotransmitter's role in normal behavior was, until now, unclear.

"This current finding explains prior work in humans that found that narcoleptics lack the arousing response to light, unlike other equally sleepy individuals, and that both narcoleptics and Parkinson's patients have an increased tendency to be depressed compared to others with chronic illnesses," said Siegel, who is also a member of the UCLA Brain Research Institute and chief of neurobiology research at the Sepulveda Veterans Affairs Medical Center in Mission Hills, Calif.

Prior studies of the behavioral role o
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers help in search for new ways to image, therapeutically target melanoma
2. Univesity of Notre Dame researchers form new partnership to help trauma patients
3. Ohio State researchers design a viral vector to treat a genetic form of blindness
4. Researchers reveal potential treatment for sickle cell disease
5. Senior citizens as co-researchers to improve urban planning
6. Plant researchers locate transporter used for nicotine metabolism
7. Live-action films of worm sperm help researchers track critical fertility enzymes
8. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
9. Researchers identify potential risk factors for severe altitude sickness
10. Moffitt Cancer Center researchers find more clues to causes of breast cancer
11. Georgetown researchers examine 21-year series of nipple sparing mastectomy cases and find no cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... (PRWEB) October 20, 2014 My Clients ... management software application. The new module enables easy ... receive full life-cycle quality care. , This application allows ... within their practice, attach a to-do item to a ... and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... Rockynol Retirement Community broke ground on ... $11 million project will include the latest in Assisted ... full-service restaurant style dining. , “We are excited to ... Living apartments,” said Kara Hanzie, Rockynol Executive Director during ... care and this investment is proof of our commitment.” ...
(Date:10/20/2014)... 20, 2014 Final Cut Pro X Plugin ... the Citrus theme for FCPX filmmakers . , “Fun, ... describe the Citrus theme” Says Christina Austin, CEO of Pixel ... so professional.” , Citrus comes with all the tools needed ... are: four transitions for added style, a title screen for ...
(Date:10/20/2014)... Houston, Texas (PRWEB) October 20, 2014 ... invited to present the key elements of his innovative ... visiting professor to plastic surgery residents and faculty at ... (UTMB) , where he, too, was once a medical ... of the largest private cosmetic plastic surgery practices in ...
(Date:10/19/2014)... Recently, BambooIndustry.com, one of the most ... range of bamboo deckings . Moreover, the company ... they are now available at deeply discounted rates. ... hard to overstate the significance of online business nowadays. ... services. The company’s workers are striving to deliver both ...
Breaking Medicine News(10 mins):Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2
... Leading Researchers to Discuss, State of Breast Cancer ... BOSTON, April 9 The Massachusetts Affiliate of Susan ... 10 at Harvard Medical,School, featuring some of the nation,s ... recent advances in breast,cancer research and the need for ...
... April 9, 2008 A company founded by an,industry ... and Canada sales,and distribution outlet for the Japanese "Paro" ... (ISC) of Japan, announced,today at the RoboBusiness Conference & ... Inc., founded by Walter Weisel, began its development,through a ...
... global clinical,research organization, is pleased to announce that it ... CRO,s in Las Vegas, Nevada from April,14 to the ... of its executive team and employees. Chiltern will be ... at 2:45 pm -- Track: Relationship Management Resource ...
... suggests that a genetic fingerprint associated with normal embryonic ... function of cancer stem cells. The research, published by ... Stem Cell, demonstrates that embryonic stem cells and multiple ... pattern that is repressed in normal differentiated cells, a ...
... ability to stabilize blood-brain barrier may play role in ... A little caffeine every day could offer some protection ... , Rabbits given the daily caffeine equivalent of one ... 12 weeks suffered relatively little damage in their blood-brain ...
... (MDC), a privately-owned chain of dental clinics in ... Dental Center, has reached,a settlement with the United ... allegations, the Justice Department announced today. Under the,agreement, ... that it,caused false or fraudulent claims for payment ...
Cached Medicine News:Health News:Massachusetts Affiliate of Susan G. Komen for the Cure to Spotlight Gaps in Breast Cancer Research 2Health News:'Paro,' the Baby Seal Service Robot From Japan, Finds a New Home in the United States With Help From JETRO 2Health News:Chiltern Will Sponsor and Present at the 17th Annual Partnerships With CRO's Meeting in Las Vegas, April 14 - 16, 2008. 2Health News:Module map links embryonic stem cells and cancer stem cells 2Health News:Caffeine May Block High Cholesterol Linked to Alzheimer's 2Health News:North Carolina Dental Services Chain Pays $10 Million to Resolve False Claims Allegations 2
(Date:10/17/2014)... The following is being released by ... The Green Park Collaborative (GPC) will bring together ... medical device and pharmaceutical companies, as well as ... 2015 at its first ever workshop on the ... Participants will discuss study designs to evaluate weight ...
(Date:10/17/2014)... NORWALK, Conn. , Oct. 17, 2014  UBM ... leading online community for endocrinologists and other clinicians who ... offers comprehensive coverage on effective use of insulin ... will eventually require insulin replacement therapy – ... up for the progressive decline in the function of ...
(Date:10/17/2014)... 2014  Ameritox SM , the nation,s leader in ... Thomas Smith , M.D., as Chief Medical Officer. In ... scientific resources for healthcare providers, patients and managed care ... at a variety of healthcare companies that have provided ... and behavioral health sides of Ameritox,s business. He most ...
Breaking Medicine Technology:Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3Ameritox Appoints New Chief Medical Officer 2
... Generex Biotechnology Corporation ( www.generex.com ) (OTCBB: ... President & Chief Executive Officer, and Dr. Eric ... Antigen Express, Inc. ( www.antigenexpress.com ) will make ... 13th Annual Healthcare Conference.  The presentation will take ...
... CITY, Calif., Sept. 7, 2011 Codexis, Inc. ... the company will be participating in the following ... ConferenceDate: Thursday, September 15, 2011 (Company presentation)Time: 8:00 ... of Financial Planning & Analysis A webcast and ...
Cached Medicine Technology:Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 2Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: