Navigation Links
UCLA researchers identify brain cells responsible for keeping us awake
Date:11/3/2011

Bright light arouses us. Bright light makes it easier to stay awake. Very bright light not only arouses us but is known to have antidepressant effects. Conversely, dark rooms can make us sleepy. It's the reason some people use masks to make sure light doesn't wake them while they sleep.

Now researchers at UCLA have identified the group of neurons that mediates whether light arouses us or not. Jerome Siegel, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, and colleagues report in the current online edition of the Journal of Neuroscience that the cells necessary for a light-induced arousal response are located in the hypothalamus, an area at the base of the brain responsible for, among other things, control of the autonomic nervous system, body temperature, hunger, thirst, fatigue and sleep.

These cells release a neurotransmitter called hypocretin, Siegel said. The researchers compared mice with and without hypocretin and found that those who didn't have it were unable to stay awake in the light, while those who had it showed intense activation of these cells in the light but not while they were awake in the dark.

This same UCLA research group earlier determined that the loss of hypocretin was responsible for narcolepsy and the sleepiness associated with Parkinson's disease. But the neurotransmitter's role in normal behavior was, until now, unclear.

"This current finding explains prior work in humans that found that narcoleptics lack the arousing response to light, unlike other equally sleepy individuals, and that both narcoleptics and Parkinson's patients have an increased tendency to be depressed compared to others with chronic illnesses," said Siegel, who is also a member of the UCLA Brain Research Institute and chief of neurobiology research at the Sepulveda Veterans Affairs Medical Center in Mission Hills, Calif.

Prior studies of the behavioral role o
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers help in search for new ways to image, therapeutically target melanoma
2. Univesity of Notre Dame researchers form new partnership to help trauma patients
3. Ohio State researchers design a viral vector to treat a genetic form of blindness
4. Researchers reveal potential treatment for sickle cell disease
5. Senior citizens as co-researchers to improve urban planning
6. Plant researchers locate transporter used for nicotine metabolism
7. Live-action films of worm sperm help researchers track critical fertility enzymes
8. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
9. Researchers identify potential risk factors for severe altitude sickness
10. Moffitt Cancer Center researchers find more clues to causes of breast cancer
11. Georgetown researchers examine 21-year series of nipple sparing mastectomy cases and find no cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... 2014 "My friend went in for ... the machine," said an inventor from Cambria Heights, N.Y. ... back a second time because the first results were ... developed the patent-pending MAMO EASY to offer a more ... saves the patient from the pain normally involved with ...
(Date:11/22/2014)... Domestic farmgate milk and dairy ... due to a fall in demand for ... amid the global financial crisis. However, these declines ... dairy manufacturers on the international scene. Strong growth ... growth, primarily due to supply constraints in some ...
(Date:11/22/2014)... November 22, 2014 The topic of ... of block retaining walls. The article states that, “While they ... several necessary steps that go into creating this powerful look.” ... a retaining wall is choosing which kind of block matches ... , B&D Rockeries says, “The two main options are concrete ...
(Date:11/22/2014)... 2014 This month has been a historical ... has received many positive reviews from some renowned review websites. ... products by launching a new selection of wonderful sexy wedding ... can enjoy free shipping and up to an 80% discount ... can always find the most suitable dress at Angeldress.co.uk, which ...
(Date:11/22/2014)... Recently, UWDress.com is gratified to introduce its ... In addition, the company has also offered an attracting ... leading online supplier of wedding dresses, UWDress.com is good ... best wedding guest gowns are provided over 20 colors, ... new selection is famous for high quality. Therefore, its ...
Breaking Medicine News(10 mins):Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:5 Step Installment of Block Retaining Walls is Topic of Latest Article by B&D Rockeries 2Health News:Sexy Wedding Dresses with Special Discounts Launched by Angeldress.co.uk 2Health News:Best Wedding Guest dresses Introduced by UWDress.com 2
... Now Approved with Four Indications for Five-Day Regimen, ... Food and Drug,Administration (FDA) has approved use of ... I.V. and oral, for the treatment of,complicated urinary ... This latest approval is based on results of ...
... The way the government keeps our,medicines ... goes through.,Those changes were the subject of ... Listen to this report from Pfizer at:, ... video, audio, text, graphics and,photos for free ...
... BKD ) announced today that its Board of ... stock of $0.50 per share for the,quarter ending September ... October 12, 2007 to holders of record of Brookdale,s ... Inc. is a leading owner and operator of senior,living ...
... VANCOUVER, Sept. 17 /PRNewswire-FirstCall/ - Cardiome Pharma ... Chairman and Chief,Executive Officer, will present an overview ... in San Francisco at 8:00am Pacific Time,(11:00am Eastern ... live webcast of Mr. Rieder,s presentation can be ...
... Million People Nationwide to take 10 Billion, Steps and ... WASHINGTON, Sept. 17 More than 1,500 YMCAs nationwide,will ... living and,healthy eating during "America On the Move Week ... with the America On the Move,Foundation, aims to educate ...
... Company,s Executive Team, VIRGINIA BEACH, Va., Sept. ... announced that Mary McCluskey, MD, has been,named Chief ... 1.5 million members. "We are excited to ... AMERIGROUP President and Chief Executive Officer. "Throughout her,career, ...
Cached Medicine News:Health News:FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis 2Health News:FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis 3Health News:FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis 4Health News:Cardiome to Present at ThinkEquity Conference 2Health News:Cardiome to Present at ThinkEquity Conference 3Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 2Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 3Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 4Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 5Health News:AMERIGROUP Names Mary McCluskey, MD, Chief Medical Officer 2Health News:AMERIGROUP Names Mary McCluskey, MD, Chief Medical Officer 3
(Date:11/22/2014)... , Nov. 21, 2014   Long Beach dentist , ... often called the gold standard in tooth replacement because they ... stable, long-lasting way to restore and preserve smiles and improve ... replace a missing tooth or as a part of a ... look and feel of a smile. The loss ...
(Date:11/22/2014)... N.C. , Nov. 21, 2014 ... system. Undoubtedly, the growing influence of patients in ... for marketing interactions. Now, more than ever, understanding ... patients for medical products is essential. ... Best Practices, LLC, benchmarked companies spent about two-thirds ...
(Date:11/21/2014)... 2014 In September 2014, the staff at ... a new product development plan that started with the ... lab coat , aptly named "Vera G.," after ... the world. The new women,s designer lab coat is ... sleek envelope collar, vertical princess and high waist seaming, ...
Breaking Medicine Technology:Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2
... an emerging,research-based pharmaceutical company, today announced that the ... Designation to its,botanical drug, Polyphenon E(R), for the ... study is currently underway at the Mayo Clinic,in ... of an,oral daily dose of Polyphenon E in ...
... Data Support Prognostic Value of Circulating Tumor Cells, ... prospective,clinical trial found the number of circulating tumor ... overall survival among metastatic,colorectal cancer patients, according to ... the Journal of Clinical Oncology., The study, ...
Cached Medicine Technology:Polyphenon Pharma Receives Orphan Drug Designation for Its Botanical Drug, Polyphenon E, for the Treatment of CLL 2Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer 2Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer 3
... efficiency by reducing errors and eliminating costly ... solution, you can spend less time on ... more time on your patient care. Cardiology ... solution. With over 50,000 installations and a ...
... PrimeSuite, is a Web Browser-based Ambulatory ... Management, Electronic Medical Record (EMR) and ... the healthcare industrys demand for dependable ... of a suite of physician-centric software ...
... the Point-of Care Electronic Medical Record portion ... encounter documentation process and electronic patient record ... that is both mobile and secure. Using ... as pentop technology with a stylus device, ...
... EMR family of products offers complete ... of specialties. Intuition EMR enables physicians ... electronic record at the point of ... less time on documentation and more ...
Medicine Products: