Navigation Links
UCLA researchers find link between intestinal bacteria and white blood cell cancer
Date:7/16/2013

Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells.

Published online ahead of press today in the journal Cancer Research, the study was led by Robert Schiestl, member of the Jonsson Cancer Center and professor of pathology and laboratory medicine, environmental health sciences, and radiation oncology.

In rodents, intestinal bacteria influence obesity, intestinal inflammation and certain types of epithelial cancers. (Epithelial cancers affect the coverings of the stomach, liver or colon.) However, little is known about the identity of the bacterial species that promote the growth of, or protect the body from, cancer or about their effect on lymphoma.

Up to 1,000 different species of bacteria (intestinal microbiota) live in the human gut. Intestinal microbiota number 100 trillion cells; over 90 percent of the cells in the body are bacteria. The composition of each person's microbiome the body's bacterial make-up is very different, due to the types of bacteria people ingest early in their lives, as well as the effects of diet and lifestyle.

Schiestl's group wanted to determine whether differences in peoples' microbiomes affect their risk for lymphoma, and whether changing the bacteria can reduce this risk. They studied mice with ataxia-telangiectasia (A-T), a genetic disease that in humans and mice is associated with a high rate of B-cell lymphoma. They discovered that, of mice with A-T, those with certain microbial species lived much longer than those with other bacteria before developing lymphoma, and had less of the gene damage (genotoxicity) that causes lymphoma.

"This study is the first to show a relationship between intestinal microbiota and the onset of lymphoma," Schiestl said. "Given that intestinal microbiota is a potentially modifiable trait, these results hold considerable promise for intervention of B-cell lymphoma and other diseases."

The scientists also were able to create a detailed catalog of bacteria types with promoting or protective effects on genotoxicity and lymphoma, which could be used in the future to create combined therapies that kill the bacteria that promote cancer (as antibiotics do) and increase the presence of the bacteria that protect from cancer (as probiotics do).


'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Cancer researchers discover how BRCA1 mutation starts breast, ovarian cancers
2. Notre Dame researchers offer new insights on cancer cell signaling
3. Use redistricting maps to make organ allocation more equitable, Johns Hopkins researchers advocate
4. Sanford-Burnham researchers develop novel nanoparticle to deliver powerful RNA interference drugs
5. Researchers investigate mechanism of Alzheimers therapy
6. Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
7. Researchers use immunocytochemistry to determine ALK status
8. Researchers find 2 new methods to determine ALK status
9. CWRU researchers trace inner-city womens health issues to childhood traumas
10. Penn Medicine researchers discover link between fear and sound perception
11. UCI researchers awarded $2.27 million to create novel diabetes treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... Fairfax, VA (PRWEB) , ... May 26, 2017 ... ... is pleased to announce a new educational seminar to focus on current legislative ... Regulatory News(LEARN) seminar will begin at 1 p.m. Sunday, Sept. 10, and will ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... copper, antimicrobial, mesh back 24/7 task chair specifically designed for clinical areas. Genie ... are thrilled to partner with Cupron® to provide customers with a game changing ...
(Date:5/26/2017)... , ... May 26, 2017 , ... Rob Lowe acts ... upcoming production of the series is on hiking in American. Viewers can reconnect with ... the great benefits of hiking. , Many consumers have looked for an inventive new ...
(Date:5/26/2017)... ... ... “Just What Happened in the Garden of Eden”: retells the stories of three Bible figures ... of published author, Penelope Colt, mother, trader, horse farmer, artist and a former GM journeyman. ... three. At six, they moved to Dayton, Ohio, where Penny graduated high school. ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Alan I. Benvenisty, MD is dual board ... He is known for his distinguished expertise and experience in the diagnosis and treatment ... training in treating renovascular disease and aortic aneurysm . He is known for ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
(Date:5/6/2017)... Provista , a proven leader in the supply chain industry ... Jim Cunniff as the company,s new president and CEO. ... Provista, including most recently serving as the president and CEO ... He assumed his new role with Provista on May 1, ... says Jody Hatcher , president, Sourcing and Collaboration Services ...
(Date:5/4/2017)... 4, 2017  Fortuna Fix Inc. (" Fortuna "), ... first to eliminate the need for embryonic and fetal stem ... neurodegenerative diseases. Fortuna announced today the ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald , ... and Professor James Giordano , PhD. "We ...
Breaking Medicine Technology: