Navigation Links
UCLA researchers find blood stem cells originate and are nurtured in the placenta
Date:3/5/2008

tists learn how to generate self-renewing blood stem cells in a more natural way, by providing the correct developmental cues from the environment in which the cells develop.

Currently, patients with certain types of leukemia have one shot at a cure a bone marrow transplant. However, there arent nearly enough bone marrow donors to provide patients with perfect matches. Use of a less than perfect donor match carries a risk of graft vs. host disease, in which the immune cells from the donated marrow attack the body of the transplant patient. Cord blood contains blood stem cells, but not in large enough quantities to transplant an adult patient, Mikkola said.

If researchers could grow blood stem cells, those cells could be transplanted into these patients. The blood stem cells would then differentiate into a new, and healthy, blood supply. And with the recent success in creating induced pluripotent stem cells (iPS) from human skin cells, a patients own skin cells could perhaps be used to create iPS cells. Those cells could then be transformed into blood stem cells, creating an immune-compatible source of blood supply that eliminates the risk of graft vs. host disease.

In her previous research, Mikkola and collaborators in Harvard and France had discovered that the placenta contained a large pool of blood stem cells, but it wasnt clear if they originated elsewhere and migrated to the placenta to self-renew. Using a unique mouse model, a mouse embryo without a heartbeat, Mikkola and her team were able to find the blood stem cells at the site of their origin because there was no circulation of blood through the body.

Using this model, we identified that the placenta has the potential to make hematopoietic (blood) stem cells with full differentiation ability to create all the major lineages of blood cells, Mikkola said. The placenta acts as a sort of kindergarten for these newly made blood stem cells, giving them the first education
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Garth Brooks Chicago tickets go on sale Friday, ... Garth Brooks was one of the leaders on the country ... 1989. Since "Much Too Young (To Feel This Damn Old)" was ... Okl. native and in the years that he has been away ... stage and in the recording studio. Between 2001 and 2009, fans ...
(Date:7/25/2014)... 25, 2014 -- The Elizabeth Glaser Pediatric AIDS ... the Medicines Patent Pool (MPP) and Gilead Sciences, ... (TAF), a promising new HIV medication. The agreement ... (AIDS 2014) in Melbourne, Australia. , While ... early data suggests it could be a key ...
(Date:7/25/2014)... A report released by the Juvenile Diabetes ... 2013 (July 1, 2012- June 30, 2013). , Outside of ... is the largest single funder of type 1 diabetes research ... with most of the top research centers. There is ... 1 diabetes in the near future. , Since the 2008 ...
(Date:7/25/2014)... Mateo, CA (PRWEB) July 25, 2014 ... an upcoming episode of Innovations with Ed Begley Jr, ... and show times TBA. , For more than four ... the Bay Area community through its residential alcohol and ... will educate on Project Ninety's humble idea and how ...
(Date:7/25/2014)... 2014 Stwd.co.uk, one of the leading ... of cheap evening dress for women. In ... big promotion for these items. They are available at ... last until August 30. , “We are pleased to ... outfits, we have a large number of stylish special ...
Breaking Medicine News(10 mins):Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 2Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 3Health News:Report: JDRF 2013 Annual Research Spending Down by $50 million 2Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 2Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 3Health News:Famous Supplier Stwd.co.uk Announces Its New Selection of Evening Dresses for Women 2
... The number of airline mishaps attributed to pilot error ... analysis conducted by researchers at the Johns Hopkins Bloomberg ... airline mishaps remained stable during that time, the proportion ... rate of mishaps related to a pilots poor decision-making ...
... New Advice for Doctors About Low-Fat, Low-Carb Restricted ... 28 The American,Diabetes Association (ADA) today issued ... providers treat people with diabetes,using the most current ... occurs in the Medical Nutrition Therapy,section dealing with ...
... deprive them of rest needed for healing, study says ... patterns of intensive care unit (ICU) patients are so ... restorative phases of sleep that help promote healing, says ... Southwestern Medical Center at Dallas. , The study ...
... Eclipsys Corporation(R),(Nasdaq: ECLP ), The Outcomes ... 2008 JPMorgan Healthcare Conference taking place from,January 7th ... http://www.newscom.com/cgi-bin/prnh/20050209/FLW006LOGO ), Eclipsys executives will ... 3:00 p.m. Pacific time. To access the live ...
... The National Drug,Intelligence Center (NDIC), a ... nation,s principal center for strategic drug intelligence, ... This strategic,assessment presents an analysis of key ... and abuse in the,United States. The assessment ...
... SAN FRANCISCO, Dec. 27 OneMedPlace will hold its ... the Sir Francis Drake,Hotel in Union Square., This ... cap public,companies and early stage venture backed companies to ... both public and private, will present at,the conference and ...
Cached Medicine News:Health News:Pilot error declines as factor in airline mishaps 2Health News:ADA Issues New Clinical Practice Recommendations 2Health News:ADA Issues New Clinical Practice Recommendations 3Health News:ICU Patients Not Getting Enough Sleep 2Health News:Eclipsys to Present at JPMorgan Healthcare Conference 2Health News:Eclipsys to Present at JPMorgan Healthcare Conference 3Health News:National Drug Intelligence Center Releases 2008 National Methamphetamine Threat Assessment 2Health News:OneMedPlace Emerging Healthcare Technologies Finance Forum Jan 7, 8th 2
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
(Date:7/25/2014)... NORTH CHICAGO, Ill., July 25, 2014 ... PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION ... RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION AbbVie (NYSE: ... quarter ended June 30, 2014. "This was ... and earnings per share above our original guidance and announced ...
(Date:7/24/2014)... , July 24, 2014   AcelRx Pharmaceuticals, Inc. ... focused on the development and commercialization of innovative therapies ... confirmed the PDUFA date for Zalviso remains July 27, ... rumor circulated online stating the Food and Drug Administration ... there has been no notification to the company from ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2AbbVie Reports Second-Quarter 2014 Financial Results 2AbbVie Reports Second-Quarter 2014 Financial Results 3AbbVie Reports Second-Quarter 2014 Financial Results 4AbbVie Reports Second-Quarter 2014 Financial Results 5AbbVie Reports Second-Quarter 2014 Financial Results 6AbbVie Reports Second-Quarter 2014 Financial Results 7AbbVie Reports Second-Quarter 2014 Financial Results 8AbbVie Reports Second-Quarter 2014 Financial Results 9AbbVie Reports Second-Quarter 2014 Financial Results 10AbbVie Reports Second-Quarter 2014 Financial Results 11AbbVie Reports Second-Quarter 2014 Financial Results 12AbbVie Reports Second-Quarter 2014 Financial Results 13AbbVie Reports Second-Quarter 2014 Financial Results 14AbbVie Reports Second-Quarter 2014 Financial Results 15AbbVie Reports Second-Quarter 2014 Financial Results 16AbbVie Reports Second-Quarter 2014 Financial Results 17AbbVie Reports Second-Quarter 2014 Financial Results 18AbbVie Reports Second-Quarter 2014 Financial Results 19AbbVie Reports Second-Quarter 2014 Financial Results 20AbbVie Reports Second-Quarter 2014 Financial Results 21AbbVie Reports Second-Quarter 2014 Financial Results 22AbbVie Reports Second-Quarter 2014 Financial Results 23AbbVie Reports Second-Quarter 2014 Financial Results 24AbbVie Reports Second-Quarter 2014 Financial Results 25AbbVie Reports Second-Quarter 2014 Financial Results 26AbbVie Reports Second-Quarter 2014 Financial Results 27AbbVie Reports Second-Quarter 2014 Financial Results 28AbbVie Reports Second-Quarter 2014 Financial Results 29AbbVie Reports Second-Quarter 2014 Financial Results 30AbbVie Reports Second-Quarter 2014 Financial Results 31AbbVie Reports Second-Quarter 2014 Financial Results 32AbbVie Reports Second-Quarter 2014 Financial Results 33AbbVie Reports Second-Quarter 2014 Financial Results 34AbbVie Reports Second-Quarter 2014 Financial Results 35
... 5, 2011 meridianEMR, the market leader in EHR ... Somerville, New Jersey was the first meridianEMR customer to ... Centers for Medicare and Medicaid Services (CMS). On July ... $54,000 for three physicians via direct deposit. The group ...
... Biotech Ltd. (Nasdaq: SVA ), a leading ... of Jacob Chik Keung Ho, its Chief Financial Officer, for ... a new Chief Financial Officer to replace Mr. Ho, who ... 2011.  Ms. Nan Wang, Vice President of Sinovac, has been ...
Cached Medicine Technology:meridianEMR® Customers Start Receiving Meaningful Use Incentive Payments 2meridianEMR® Customers Start Receiving Meaningful Use Incentive Payments 3Sinovac Announces Management Changes 2Sinovac Announces Management Changes 3
iSleep 20i is an advanced high performance CPAP with outstanding self-adjusting i‑technology....
Spectrum Dynamics empowers Nuclear Imaging with the SmartR Technology,of the D-SPECT Cardiac Imaging System. The D-SPECT is powered by BroadView Technology to provide unprecedented throughput, whil...
Diagnosoft HARP is designed for rapid analysis of tagged cardiac MR images using the HARP technology, which is packaged into an intuitive, easy-to-use graphic user interface....
... accurately differentiates clinically significant progression of ... providing an advanced, proven method to ... patients. , ,The software applies knowledge ... in which the actual test/retest variability ...
Medicine Products: