Navigation Links
UCLA researchers discover protein that shuttles RNA into cell mitochondria
Date:8/6/2010

energy, mitochondria also are involved in a broad range of other cellular processes, such as signaling, differentiation, death, control of the cell cycle and growth.

The study could have implications for studying and treating certain cancers, which rely on cellular energy to grow and spread, as well as mitochondrial disorders such as neuromuscular diseases. The study could also result in new ways to think about attacking neurodegenerative disorders, such as Parkinson and Alzheimer diseases, which have recently been linked to the function of mitochondria.

"When we're talking about looking for ways to cure cancer, we fundamentally need to understand what makes cells grow and die and the mitochondrion is right at the heart of these issues," said Carla Koehler, a professor of chemistry and biochemistry, Jonsson Cancer Center researcher and co-senior author of the study. "This new and novel pathway for transporting RNA into the mitochondria is shedding new light on the evolving role and importance of mitochondria function in normal physiology and a wide variety of diseases. If we can understand how this pathway functions in healthy cells we could potentially uncover defects that help in transforming normal cells into cancer cells."

PNPASE was identified in 2004 by Teitell and his team as they attempted to find proteins that interact with TCL1, a human lymphoma-promoting cancer gene that has been used to generate genetic models of lymphocyte cancer. Mass spectrometry uncovered PNPASE, which had a signature sequence that suggested that it trafficked into and localized within the mitochondria of cells.

Once localized, Teitell, Koehler and post-doctoral fellow Geng Wang turned their attention to the function of PNPASE, which generated the unexpected results reported in this study. Prior to their discovery, it was not known what pathway was used to get RNA into the mitochondria. PNPASE mediates the movement of RNA from the cell cytoplasm
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. NIST researchers measure high infrared power levels from some green lasers
3. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
4. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
5. Researchers identify key enzyme in DNA repair pathway
6. Researchers study benefits of white button mushrooms
7. Use of decision-aid program increases safety for women experiencing abuse, researchers find
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
10. Researchers pinpoint key stem cells for eating and sex
11. BUSPH researchers link widely used chemicals to ADHD in children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers discover protein that shuttles RNA into cell mitochondria
(Date:6/2/2015)... June 02, 2015 Each year, Cosmetic ... Choice Beauty Awards. This year, the organization’s members – ... winner of the QVC® Beauty Quest Award at the ... Micro Emulsion (ME) Technology and 2-in-1 approach to skincare ... noting the brand’s loyal consumer and professional fan bases, ...
(Date:6/2/2015)... Join us for a new event in Westwood, New Jersey—the ... , who overcame her brain aneurysm during the summer of ... awareness and funds for brain aneurysm research. , Rhonda ... will be one less case of someone suffering from a ... the 1st Anniversary Awareness Walk in Honor of Rhonda ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Specialty ... audit, compliance and risk solutions , and Radar ... risk management effectiveness gap-improvement program. , All organizations ... uncertainty on objectives. Organizations not only assess and ... capabilities to do this (risk managing) thereby embedding ...
(Date:6/1/2015)... NY (PRWEB) June 02, 2015 ... Lynn Lester as a 2015-2016 inductee into ... recognized with this prestigious distinction for leadership in business. ... professional women, boasting more than 700,000 members and over ... Lynn Lester with this prestigious award,” said NAPW President ...
(Date:6/1/2015)... 02, 2015 The National Association ... as a 2015-2016 inductee into its VIP Professional ... this prestigious distinction for leadership in safety, environment, health ... organization exclusively for professional women, boasting more than 700,000 ... pleased to present Lourinda with this important honor,” said ...
Breaking Medicine News(10 mins):Health News:Scalisi Skincare Wins Coveted CEW QVC Beauty Quest Award for Innovative and Patented Formulation 2Health News:New Awareness Raising Event in Westwood, NJ to Benefit Renowned Brain Aneurysm Foundation 2Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 2Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 3Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 4Health News:National Association of Professional Women Inducts Lynn Lester, Director of Clinical Operations/CEO, Recovery Treatment Center, Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Lourinda Willey, Owner and Principal of Lourinda R. Willey LLC, Into its VIP Professional Woman of the Year Circle 2
... interdisciplinary team of researchers at Brigham and Women,s ... Sciences and Technology has demonstrated a better way to ... engineered nanoparticles that can inhibit a signaling pathway and ... area. Details of their work appear on April 20, ...
... Lincare Holdings Inc. (Nasdaq: LNCR ), a ... to patients in the home, today announced financial results for ... March 31, 2009, net revenues were $371.7 million, compared with ... 2008. Net income for the quarter ended March 31, ...
... April 20 Amgen (Nasdaq: AMGN ) today ... results on Thursday, April 23, 2009 after the close of ... conference call with the investment community at 2 p.m. Pacific ... Kevin Sharer, chairman and chief executive officer, and other members ...
... not have same impact, study finds , , MONDAY, April ... beverages can have a negative effect on the body,s ... increasing the risk of heart attack and stroke, a ... have that kind of impact, the study found. , ...
... SYK ) reported operating results for the quarter ended March ... , Net sales increased ... $1,601 million , Orthopaedic Implants ... reported) , MedSurg Equipment sales ...
... Environmental or therapeutic contact also led to poorer outcomes, ... Thyroid cancer patients who,ve previously been exposed to radiation ... patients, a new study finds. , Researchers at Mount ... who,d been exposed to radiation -- for example, in ...
Cached Medicine News:Health News:Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors 2Health News:Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors 3Health News:Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors 4Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 2Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 3Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 4Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 5Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 6Health News:Lincare Holdings Inc. Announces First Quarter 2009 Financial Results 7Health News:Amgen Announces Webcast of 2009 First Quarter Financial Results 2Health News:Stryker Operating Results for Quarter Ended March 31, 2009 2Health News:Stryker Operating Results for Quarter Ended March 31, 2009 3Health News:Stryker Operating Results for Quarter Ended March 31, 2009 4Health News:Stryker Operating Results for Quarter Ended March 31, 2009 5Health News:Stryker Operating Results for Quarter Ended March 31, 2009 6Health News:Stryker Operating Results for Quarter Ended March 31, 2009 7Health News:Stryker Operating Results for Quarter Ended March 31, 2009 8Health News:Radiation Exposure Linked to Aggressive Thyroid Cancers 2
(Date:6/1/2015)... 2015  bioMérieux, a world leader in the field ... to join the White House Forum on Antibiotic Stewardship ... as a means to address antibiotic resistance. Over 150 ... 2, 2015, to discuss the possible ways to implement ... emergence of antibiotic-resistant bacteria, and prevent the spread of ...
(Date:6/1/2015)... The Middle Eastern MRI systems market is fast ... CT because of its higher sensitivity and use of non-ionizing ... two available systems of MRI, open and closed. Open MRI ... and do not enclose the patient in a tunnel. This ... shows that one in every 6 patients suffers from claustrophobia ...
(Date:6/1/2015)... SEATTLE , June 1, 2015 ... biotechnology company engaged in the development and commercialization ... announced that it has met with the U.S. ... for the filing of an Investigational New Drug ... As a result of the meeting, Neovia ...
Breaking Medicine Technology:bioMerieux Honored to Participate in the White House Forum on Antibiotic Stewardship 2bioMerieux Honored to Participate in the White House Forum on Antibiotic Stewardship 3Middle East Open System MRI Market - Growth, Trends And Forecasts (2014 - 2019) 2Neovia Oncology Announces First IND Meeting 2
... Sept. 16 ScriptPro has been awarded a contract ... National Institutes of Health (NIH) in Bethesda, ... drug information systems will be implemented in the National ... and identification of drugs and enhance the safety and ...
... YORK, Sept. 16 Reportlinker.com announces that ... in its catalogue: Electrophysiology ... and Market Forecasts to 2016 ... Electrophysiology Devices - Global Pipeline Analysis, Opportunity ...
Cached Medicine Technology:National Institutes of Health Chooses ScriptPro for Pharmacy Automation 2Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 4Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 5Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 6Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 7Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 8Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 9Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 10Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 11
The playful pattern of this lens features sky-blue forms fanning out from the center of your eye....
Each jet black lens features a mesmerizing thin white line that spirals toward the center of the pupil....
The opaque outer circle will white-out even the darkest iris, making your pupil the only spot of black in a sea of white....
Yellow flames radiate out from the center of eye, held in check by the fire-engine red perimeter....
Medicine Products: