Navigation Links
UCLA researchers discover protein that shuttles RNA into cell mitochondria
Date:8/6/2010

energy, mitochondria also are involved in a broad range of other cellular processes, such as signaling, differentiation, death, control of the cell cycle and growth.

The study could have implications for studying and treating certain cancers, which rely on cellular energy to grow and spread, as well as mitochondrial disorders such as neuromuscular diseases. The study could also result in new ways to think about attacking neurodegenerative disorders, such as Parkinson and Alzheimer diseases, which have recently been linked to the function of mitochondria.

"When we're talking about looking for ways to cure cancer, we fundamentally need to understand what makes cells grow and die and the mitochondrion is right at the heart of these issues," said Carla Koehler, a professor of chemistry and biochemistry, Jonsson Cancer Center researcher and co-senior author of the study. "This new and novel pathway for transporting RNA into the mitochondria is shedding new light on the evolving role and importance of mitochondria function in normal physiology and a wide variety of diseases. If we can understand how this pathway functions in healthy cells we could potentially uncover defects that help in transforming normal cells into cancer cells."

PNPASE was identified in 2004 by Teitell and his team as they attempted to find proteins that interact with TCL1, a human lymphoma-promoting cancer gene that has been used to generate genetic models of lymphocyte cancer. Mass spectrometry uncovered PNPASE, which had a signature sequence that suggested that it trafficked into and localized within the mitochondria of cells.

Once localized, Teitell, Koehler and post-doctoral fellow Geng Wang turned their attention to the function of PNPASE, which generated the unexpected results reported in this study. Prior to their discovery, it was not known what pathway was used to get RNA into the mitochondria. PNPASE mediates the movement of RNA from the cell cytoplasm
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. NIST researchers measure high infrared power levels from some green lasers
3. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
4. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
5. Researchers identify key enzyme in DNA repair pathway
6. Researchers study benefits of white button mushrooms
7. Use of decision-aid program increases safety for women experiencing abuse, researchers find
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
10. Researchers pinpoint key stem cells for eating and sex
11. BUSPH researchers link widely used chemicals to ADHD in children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers discover protein that shuttles RNA into cell mitochondria
(Date:11/23/2014)... Locks-Magnetic.com, a notable magnetic locks maker, has ... new products are available at low rates up to ... of the new emergency doors. The emergency door adopts ... choose from several colors. All of the products are ... release is not as easy as many people think. ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its ... beach wedding dresses. “If you are looking for gorgeous ... soon as possible. Here you can enjoy 70% off ... , Holding a big marriage ceremony is the most ... beach wedding dress is uppermost priority. Ophelia, one of ...
(Date:11/23/2014)... November 23, 2014 Wright & Schulte ... of Ohio and West Virginia residents who allege that ... health disorders due to drinking C8 contaminated water ... West Virginia. According to the C8 complaints, the plaintiffs ... worked or lived in at least one of the ...
(Date:11/22/2014)... (PRWEB) November 23, 2014 Cancer researchers ... a connection between intercellular communication tunnels and the growth ... the full story on the Surviving Mesothelioma website. ... and the University of Minnesota have just released their ... information and materials between cells. They found that ...
(Date:11/22/2014)... 2014 BambooFlooringChina.com is a famous ... proudly released its new collection of bamboo mats ; ... to 29% off. , According to the sales ... grass, making it a highly renewable resource. Their bamboo mats ... mixing color which comes from natural bamboo with caramel bamboo ...
Breaking Medicine News(10 mins):Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 3Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 4Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2
... One in eight parents reported that his or ... laboratory testing and/or appointments with specialists during the ... payment, according to a study, presented Sunday, Oct. 3, ... and Exhibition in San Francisco. For the ...
... , FRIDAY, Oct. 1 (HealthDay News) -- Doctors who take ... lifestyle habits to their patients than doctors who gobble down ... hit the gym, according to new research. Additionally, the ... they,d been well-trained to counsel their patients on lifestyle changes ...
... identify obscure cartoon characters than the native plants and animals ... connection to the natural world can have a profound impact ... author who coined the phrase, "nature-deficit disorder," will address this ... Pediatrics (AAP) National Conference & Exhibition Saturday, Oct. 2. His ...
... department at a mid-sized hospital were able to increase ... for measuring general technologist productivity, according to a study ... American College of Radiology ( www.jacr.org ). ... priorities that may be difficult to achieve simultaneously," said ...
... Johns Hopkins scientists have discovered a way to turn off ... mice, a discovery that could have implications for the millions ... peanuts and milk. The findings, published online in the ... could be trained to tolerate food allergies that lead to ...
... review article published in the October issue of ... Clinic physicians differentiate the ethical and legal permissibility ... comfort measures, specifically palliative sedation, from that of ... that palliative sedation has an important place on ...
Cached Medicine News:Health News:1 in 8 parents forgoes pediatrician-recommended care 2Health News:Doctors' Health, Well-Being Affect Patient Counseling 2Health News:Doctors' Health, Well-Being Affect Patient Counseling 3Health News:Johns Hopkins researchers turn off severe food allergies in mice 2
(Date:11/21/2014)... MONTREAL , 21. November 2014 ... hat heute bekannt gegeben, dass ... – EMA) die Kennzeichnung als Orphan-Medizinprodukt ... Produktkandidat des Unternehmens zur Behandlung von ... eine seltene, stark beeinträchtigende genetische Krankheit, ...
(Date:11/21/2014)... 20, 2014  Edwards Lifesciences Corporation (NYSE: ... heart valves and hemodynamic monitoring, announced today that it ... support a strong launch of Edwards Lifesciences Foundation,s new ... improve the global communities where its employees live and ... giving will exceed $8 million, including more than $7 ...
(Date:11/21/2014)... BRYDGES, Ontario , Nov. 20, 2014 /PRNewswire/ ... monitor mounting solutions and reading room environment guidance, ... their newest musculoskeletal radiology reading room, which may ... room designs at Penn Medicine. ... by the American College of Radiology,s Imaging 3.0 ...
Breaking Medicine Technology:Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3Edwards Lifesciences Increases Charitable Giving In 2014 To Support Launch Of Every Heartbeat Matters 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3
... TARRYTOWN, N.Y., April 18, 2012 Bayer HealthCare today ... has cleared its CONTOUR® Next EZ, a new blood ... States.  CONTOUR Next EZ includes an easy-to-use meter and ... new BGM system is being introduced on a market-by-market ...
... launches their Latching Micro-D™ connectors with a new ... quick cable connections to rack and panel equipment.  ... weight, the new latching Micro-D™ connectors, at .050" ... including pull tests that exceeds 100 pound pull ...
Cached Medicine Technology:U.S. FDA Clears Bayer HealthCare's CONTOUR® Next EZ Blood Glucose Monitoring System 2U.S. FDA Clears Bayer HealthCare's CONTOUR® Next EZ Blood Glucose Monitoring System 3Omnetics Launches Panel Mounted Latching Micro-D™ Connectors 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: