Navigation Links
UCLA researchers discover protein that shuttles RNA into cell mitochondria
Date:8/6/2010

energy, mitochondria also are involved in a broad range of other cellular processes, such as signaling, differentiation, death, control of the cell cycle and growth.

The study could have implications for studying and treating certain cancers, which rely on cellular energy to grow and spread, as well as mitochondrial disorders such as neuromuscular diseases. The study could also result in new ways to think about attacking neurodegenerative disorders, such as Parkinson and Alzheimer diseases, which have recently been linked to the function of mitochondria.

"When we're talking about looking for ways to cure cancer, we fundamentally need to understand what makes cells grow and die and the mitochondrion is right at the heart of these issues," said Carla Koehler, a professor of chemistry and biochemistry, Jonsson Cancer Center researcher and co-senior author of the study. "This new and novel pathway for transporting RNA into the mitochondria is shedding new light on the evolving role and importance of mitochondria function in normal physiology and a wide variety of diseases. If we can understand how this pathway functions in healthy cells we could potentially uncover defects that help in transforming normal cells into cancer cells."

PNPASE was identified in 2004 by Teitell and his team as they attempted to find proteins that interact with TCL1, a human lymphoma-promoting cancer gene that has been used to generate genetic models of lymphocyte cancer. Mass spectrometry uncovered PNPASE, which had a signature sequence that suggested that it trafficked into and localized within the mitochondria of cells.

Once localized, Teitell, Koehler and post-doctoral fellow Geng Wang turned their attention to the function of PNPASE, which generated the unexpected results reported in this study. Prior to their discovery, it was not known what pathway was used to get RNA into the mitochondria. PNPASE mediates the movement of RNA from the cell cytoplasm
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. NIST researchers measure high infrared power levels from some green lasers
3. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
4. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
5. Researchers identify key enzyme in DNA repair pathway
6. Researchers study benefits of white button mushrooms
7. Use of decision-aid program increases safety for women experiencing abuse, researchers find
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
10. Researchers pinpoint key stem cells for eating and sex
11. BUSPH researchers link widely used chemicals to ADHD in children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers discover protein that shuttles RNA into cell mitochondria
(Date:8/28/2014)... In the coming years, considerable effort and ... of the brain. This webinar examines many of the ... one another at their synapses. , Event Date: Tuesday, ... / 10 AM PDT / 6 PM BST, Live ... - Professor; Group Leader, STED Microscopy of Synaptic Function ...
(Date:8/28/2014)... The animal feed yeast market is booming due to ... Leading companies in the animal feed yeast market are ... high nutritive value. Leading livestock industries are increasingly using ... The market for live yeast was the largest in ... demand for animal feed yeast in the livestock industry. ...
(Date:8/28/2014)... FL (PRWEB) August 28, 2014 ... completed major initiatives with Catholic Health Initiatives (CHI) ... Wash., (Franciscan Health) to provide training, helpdesk and ... will provide a shared electronic, universal health record ... as many as 350 CSI contractors on site ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 ... into Heartbeat Experts’ perspectives on stakeholder management ... Download the flash report to speak with ... launching Breast Cancer product:, , ... an increasingly crowded market ,     Understanding ...
(Date:8/28/2014)... Home Care Assistance of Scottsdale , a ... to welcome Carrie Rose as the office's new Client ... worked as a caregiver in assisted living and memory ... skilled nursing facilities for several hospice companies in the ... State of Arizona in the Direct Care Workers program. ...
Breaking Medicine News(10 mins):Health News:Exploring Neurons and Synapses: Imaging Tools and Techniques Webinar - Registration Open Now 2Health News:9.3% CAGR for Animal Feed Yeast Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 2Health News:9.3% CAGR for Animal Feed Yeast Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 3Health News:9.3% CAGR for Animal Feed Yeast Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 4Health News:9.3% CAGR for Animal Feed Yeast Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5Health News:CSI Healthcare IT, Catholic Health Initiatives Complete OneCare Go-Live 2Health News:Download HeartBeat Experts White Paper: Stakeholder Management for New Breast Cancer Products 2Health News:Home Care Assistance Expands Staff to Meet Growing Demand for In-Home Care Services in Scottsdale 2Health News:Home Care Assistance Expands Staff to Meet Growing Demand for In-Home Care Services in Scottsdale 3
... today announced their plans to expand their online video ... overwhelming success achieved by the website since its inception ... library has been visited by physicians from 64 different ... from repeat visits and the average length of stay ...
... Recent Developments at Major Patenting Authorities WorldwidePHILADELPHIA and LONDON, ... Thomson Reuters today released its 2009 Patent Focus ... Intellectual Asset Management magazine, and published in the ... , this report explores recent activities at each of ...
... SEATTLE, Feb. 17 Cell Therapeutics, Inc. (Nasdaq and ... a press release in Italy in response to information ... CTI,s business operations and financial condition, which was also ... February 17, 2009, the Borsa Italiana has confirmed that ...
... 17 The civil rights movement gained a ... of Representatives voted Feb. 17 to recognize the ... by American Life League Associate group North Dakota ... of The Personhood of Children Act (House Resolution ...
... Consumers who purchased raw milk from the Swiss Villa ... after Feb. 9 are advised to discard it immediately ... Secretary Dennis Wolff said today. Raw milk has not ... a result of the potential contamination, but if people ...
... Shenghuo,Pharmaceutical Holdings, Inc. (NYSE Alternext US: KUN) ("China ... 10, 2009, it received a,deficiency letter from the ... the,"Exchange") stating that the Company was not in ... standards due to the Company,s failure to,hold an ...
Cached Medicine News:Health News:Physicians online library is a worldwide hit 2Health News:Physicians online library is a worldwide hit 3Health News:Thomson Reuters Releases 2009 Patent Focus Report 2Health News:Cell Therapeutics to Resume Trading on MTA and NASDAQ 2Health News:North Dakota Personhood Bill Passes State House 51-41 2Health News:Consumer Advisory: Agriculture Department Warns of Tainted Raw Milk Sold By Dauphin County Dairy 2Health News:China Shenghuo Receives Notice from NYSE Alternext US Regarding Listing Standards 2Health News:China Shenghuo Receives Notice from NYSE Alternext US Regarding Listing Standards 3
(Date:8/28/2014)... /PRNewswire-iReach/ -- EDGE Orthopaedics, a new entry in ... announce they have received their second FDA 510(k) ... Fracture Plating System. The VIEW Plating ... indications within the mid-foot. The system includes titanium ... (CC), Talonavicular (TN) and Evans plates along with ...
(Date:8/28/2014)... 28, 2014 Takeda Pharmaceutical Company Limited ... and submissions of data from a 10-year epidemiology ... United States (U.S.) Food and Drug ... the Japanese Ministry of Health, Labour, and Welfare ... Agency (PMDA) for pioglitazone containing medicines, including ACTOS ...
(Date:8/28/2014)... CHENGDU, China , Aug. 28, 2014 /PRNewswire/ ... TPI ), a pharmaceutical company that specializes ... branded generics and active pharmaceutical ingredients (API) today ... the Company,s Qionglai Facility (QLF). ... Manufacturing Practice (GMP) dataset for China Food & ...
Breaking Medicine Technology:EDGE Orthopaedics Receives Second FDA Clearance 2Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 2Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 3Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 4Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 5Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 6TPI Submits Dataset for GMP Inspection at Qionglai Facility (QLF) 2
... 2010 Kensey Nash Corporation (Nasdaq: KNSY ... in November.   Michael Celano, Kensey Nash,s ... the Oppenheimer 21st Annual Healthcare Conference at the Waldorf ... p.m. (ET).  To hear the live webcast of the ...
... (Nasdaq: SLTM ), a global leader in the ... ended September 30, 2010. Revenue for the third quarter was ... as compared to the third quarter 2009 revenue of $17.8 ... by a year-over-year 40% increase in sales of treatment tips ...
Cached Medicine Technology:Solta Medical Reports Third Quarter 2010 Results 2Solta Medical Reports Third Quarter 2010 Results 3Solta Medical Reports Third Quarter 2010 Results 4Solta Medical Reports Third Quarter 2010 Results 5Solta Medical Reports Third Quarter 2010 Results 6Solta Medical Reports Third Quarter 2010 Results 7Solta Medical Reports Third Quarter 2010 Results 8
... ROM Elbow Orthosis features aluminum cuffs that ... arm. To ensure proper joint alignment, unique ... and distal adjustments to cuff position. Cuffs ... is necessary for use with contractures.,The hinge ...
... Brace is designed to handle post-op elbow ... The Bledsoe Extender Arm Brace should be ... of the elbow is desired. In most ... be formed, fitted and adjusted in 5 ...
... This controlled stretch ankle support helps reduce ... of motion. It is easy to apply ... its slim design fits easily into shoes. ... the ankle, and provide side-to-side support and stability. ...
... ankle support provides excellent com-pression and ... motion. The anatomically sculpted visco-elastic ... weakened or injured soft tissues under ... to apply - slips on like ...
Medicine Products: