Navigation Links
UCLA researchers discover protein that shuttles RNA into cell mitochondria
Date:8/6/2010

Researchers at UCLA's Jonsson Comprehensive Cancer Center and the departments of Chemistry and Biochemistry and Pathology and Laboratory Medicine have uncovered a role for an essential cell protein in shuttling RNA into the mitochondria, the energy-producing "power plant" of the cell.

The import of nucleus-encoded small RNAs into mitochondria is essential for the replication, transcription and translation of the mitochondrial genome, but the mechanisms that deliver RNA into mitochondria remain poorly understood.

In the current study, UCLA scientists show a new role for a protein called polynucleotide phosphorylase (PNPASE) in regulating the import of RNA into mitochondria. Reducing the expression of PNPASE decreased RNA import, which impaired the processing of mitochondrial genome-encoded RNAs. Reduced RNA processing inhibited the translation of proteins required to maintain the electron transport chain that handles oxygen to produce energy in the form of adenosine triphosphate, the energy currency of a cell. With reduced PNPASE, unprocessed mitochondrial RNAs accumulated, protein translation was inhibited and energy production was compromised, leading to stalled cell growth.

The study appears Aug. 5, 2010, in the peer-reviewed journal Cell.

"This discovery tells us that PNPASE regulates the energy producing function of mitochondria by mediating cytoplasmic RNA import," said Dr. Michael Teitell, a professor of pathology and laboratory medicine, a Jonsson Cancer Center researcher and co-senior author of the study. "The study yields new insight for how cells function at a very fundamental level. This information provides a potential new pathway to control mitochondrial energy production and possibly impact the growth of cells, including certain types of cancer cells."

Mitochondria are described as cellular power plants because they generate most of the energy supply of the cell. In addition to supplying
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
2. NIST researchers measure high infrared power levels from some green lasers
3. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
4. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
5. Researchers identify key enzyme in DNA repair pathway
6. Researchers study benefits of white button mushrooms
7. Use of decision-aid program increases safety for women experiencing abuse, researchers find
8. Researchers uncover biological rationale for why intensive lupus treatment works
9. OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
10. Researchers pinpoint key stem cells for eating and sex
11. BUSPH researchers link widely used chemicals to ADHD in children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA researchers discover protein that shuttles RNA into cell mitochondria
(Date:10/2/2014)... October 02, 2014 USARAD Holdings ... and telemedicine solutions provider including its SecondOpinions.com® division, ... have joined its Executive Team as President & ... Brent Backhaus, USARAD’s new President and COO, is ... of progressively responsible experience in commercial-, medical- and ...
(Date:10/2/2014)... (PRWEB) October 02, 2014 Robins ... from the Associated Builders and Contractors (ABC) of ... at tonight’s banquet held at Sheraton Birmingham Hotel., ... Massachusetts, Healthcare $10 Million to $25 Million, Obelisk ... Dental Clinic, Federal Government $10 Million to $25 ...
(Date:10/2/2014)... Maureen Salamon HealthDay Reporter ... women with a neurotic personality style and prolonged stress ... new research suggests. Tracking 800 women over nearly ... most anxious, jealous and moody -- which they defined ... the risk of developing Alzheimer,s compared to women scoring ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, 2014 (HealthDay ... reduced by breast-feeding. Nor will delaying the introduction of a ... help prevent celiac disease. Those are the conclusions ... New England Journal of Medicine . The new ... celiac disease if mothers breast-feed their babies and introduce gluten ...
(Date:10/1/2014)... researchers from the University of Adelaide have developed a ... of a good outcome from treatment - from their ... on a range of factors, including clinical symptoms, cognitive ... in the patient,s blood. , Speaking in the lead ... University,s Head of Psychiatry , Professor Bernhard ...
Breaking Medicine News(10 mins):Health News:Teleradiology and Telemedicine Pioneers Brent Backhaus and Lorna Backhaus Join USARAD Holdings, INC. & SecondOpinions.com® 2Health News:Teleradiology and Telemedicine Pioneers Brent Backhaus and Lorna Backhaus Join USARAD Holdings, INC. & SecondOpinions.com® 3Health News:Robins & Morton wins nine awards from Associated Builders and Contractors 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 3Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 3Health News:Predicting the future course of psychotic illness 2
... , TUESDAY, Jan. 4 (HealthDay News) -- Nearly 60 ... victims of violence, abuse or crime in the past year. ... happened. Researchers led by David Finkelhor of the University ... parents of children up to 9 years old in 2008. More ...
... Reporter , TUESDAY, Jan. 4 (HealthDay News) -- Common ... stem cell defect, a finding that could potentially lead ... study reveals. Researchers say they discovered that a ... stem cells turn into hair-producing progenitor cells. That defect, ...
... , TUESDAY, Jan. 4 (HealthDay News) -- The ... (arrhythmias) that can cause sudden death may be underestimated, ... healthy people without heart disease found detectable changes in ... to polluted air. The findings suggest that air ...
... Jan. 4 (HealthDay News) -- Levels of schooling may affect ... heart attack called acute ST-segment elevation myocardial infarction (STEMI), a ... of heart attack, STEMI occurs when the coronary artery is ... heart. In the new study, Dr. Rajendra H. ...
... Reporter , TUESDAY, Jan. 4 (HealthDay News) -- Simply measuring ... how many years they have left. In fact, a ... older people,s future life span about as well as taking ... disease. Walking speed may not be a perfect window ...
... YORK (Jan. 4, 2011) Researchers have produced a lasting anti-cocaine ... bits of the common cold virus with a particle that mimics ... published Jan. 4 in the online edition of Molecular Therapy ... researchers say this novel strategy might be the first to offer ...
Cached Medicine News:Health News:Survey Finds Much Victimization of Children Goes Unreported 2Health News:Stem Cell Defect Might Help Spur Common Baldness 2Health News:Stem Cell Defect Might Help Spur Common Baldness 3Health News:Higher Education May Benefit Some Heart Attack Patients 2Health News:Fast Walkers May Have More Years Ahead of Them 2Health News:Fast Walkers May Have More Years Ahead of Them 3Health News:Vaccine blocks cocaine high in mice 2Health News:Vaccine blocks cocaine high in mice 3
(Date:10/1/2014)... NEW YORK , October 1, 2014 ... provider for the medical industries, announced today the expansion of its ... New York City . genae Americas was incorporated in 2011. ... centered in one of the highest concentrations of medical innovation and ... , President at genae Americas. "The expansion of genae from ...
(Date:10/1/2014)... Oct. 1, 2014  Varian Medical Systems (NYSE: ... results for the fourth quarter of fiscal year 2014 ... 22, 2014.  The news release will be followed by ... p.m. PT.  The news release and a link to ... company website at: www.varian.com/investor .  To access the ...
(Date:10/1/2014)... SAN MARCOS, Texas , Oct. 1, 2014 ... that it is scaling volume production of photoactive ... solar power technologies . While offering numerous advantages ... difficulty of producing large quantities of quantum dots ... has until now kept them from commercial utilization ...
Breaking Medicine Technology:genae Opens Offices in New York City 2Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 3
... Feb. 8, 2012   Resource Anesthesia , an anesthesia ... several new locations to its management portfolio. ... announced today that the company has added the following ... Specialty Hospital of Washington -- Hadley, 4601 Martin Luther ...
... MLAB ) today reported a 21 percent increase in revenue and ... quarter ended December 31, 2011. Highlights: ... ,000 Quarterly revenues increased 21% year over year to ... in the fiscal third quarter Quarterly non-GAAP diluted earnings ...
Cached Medicine Technology:Resource Anesthesia Adds Locations Under Management, Announces Addition of HealthStream LearningCenter® 2Mesa Labs Reports 58 Percent Increase in Third Quarter Net Income 2Mesa Labs Reports 58 Percent Increase in Third Quarter Net Income 3Mesa Labs Reports 58 Percent Increase in Third Quarter Net Income 4Mesa Labs Reports 58 Percent Increase in Third Quarter Net Income 5
... a broad selection of tip ... wide variety of ophthalmic procedures. ... packaged sterile, complete with a ... in the "off " position ...
... Accu-Temp Cauteries provide a broad ... cauterization in a wide variety ... use cautery is packaged sterile, ... to lock switch in the ...
... Cauteries provide a broad selection of ... wide variety of ophthalmic procedures. Each ... complete with a safety cap to ... position when not in use, and ...
... Cauteries provide a broad selection of ... wide variety of ophthalmic procedures. Each ... complete with a safety cap to ... position when not in use, and ...
Medicine Products: