Navigation Links
UCLA researchers discover drug resistance mechanisms in most common form of melanoma
Date:11/24/2010

ving drug resistance," said Lo, an assistant professor of dermatology. "In a big portion of cases where cancers acquire resistance to targeted drugs, the oncogene being targeted finds a way to get around the drug by developing other additional mutations."

Cancers, Lo said, are very adept at finding ways around the drugs being used to fight them.

"You hit it with an axe, but the cancer soon finds a way to mitigate the effects of the axe," he said.

Lo and his team found that these mutually exclusive mechanisms of acquired drug resistance account for about 40 percent of the patients who were treated with PLX4032 and later acquired resistance to it. In some cases, Lo found that the cancer cells began overexpressing a cell surface protein that created an alternate survival pathway for the cancer while the BRAF survival pathway was being blocked by PLX4032. In other cases, a second oncogene, NRAS, became mutated, allowing the cancer to short circuit the PLX4032-inhibited BRAF mutation and reactivate the BRAF survival pathway. PLX4032 does not target the NRAS mutation, so the cancer can begin to regrow.

Lo said he expects to find other mechanisms of resistance in the remaining 60 percent of relapsing patients where neither of the two new mechanisms were found.

"It's important to find all the mechanisms of acquired drug resistance in this type of melanoma and figure out how to target them using drugs designed to hit those specific mechanisms," he said. "We've found two mechanisms in two subsets of melanoma and we'll need different drugs to treat those two subsets."

Going forward, Lo and his team will study the resistance mechanisms of the two subsets discovered and any others uncovered later to perhaps find better targets for therapy. For example, targeting the cell surface protein overexpression may prove more difficult than finding what causes the overexpression further upstream and homing in on that.

"
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers shine light on how some melanoma tumors evade drug treatment
2. New function of gene in promoting cancer found by VCU researchers
3. Stanford researchers first to turn normal cells into 3-D cancers in tissue culture dishes
4. Researchers find new target for stopping tumors developing their own blood supply
5. Researchers identify PTSD measures for use in traumatic brain injury research
6. New insight into the cause of common dementia found by researchers at Mayo Clinic
7. Researchers fight Americas other drug problem
8. Researchers map the way to personalised treatment for ovarian cancer
9. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
10. AAPS presents awards to exemplary researchers
11. Yerkes researchers present at 40th Annual Society for Neuroscience Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... York, NY (PRWEB) , ... August 01, 2015 , ... ... Vine cyberespionage group , who are thought to have been behind the attack on ... the topics covered were zero day exploits, watering hole attacks and spear phishing campaigns. ...
(Date:8/1/2015)... , ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the ... of the Appalachian Trail by stepping off Springer Mountain and heading north. Since ... July 26th Phil reached Connecticut and was greeted by friends and family. He visited ...
(Date:7/31/2015)... ... 01, 2015 , ... The Honor Society of Nursing, Sigma Theta Tau International ... Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key nurse leaders from ... Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of Human Resources for ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted ... in predictive health analytics , Jvion continues to disrupt the predictive analytic ... software that targets patient and population level illness to drive prevention and better ...
(Date:7/31/2015)... Bethpage, NY (PRWEB) , ... July 31, 2015 , ... ... much as possible, even when it comes time to cook the next meal, making ... month of July by practicing best grilling tips and recipes. , Make the next ...
Breaking Medicine News(10 mins):Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... world could run using a pollution free energy source.// ... just working towards this solution to look at making hydrogen ... the hydrogen would reacts with oxygen to produce water and ... this would be pollution free. A similar mechanism is already ...
... have been able to discover a new molecular structure that ... using stem cell technology. ,The research had lead to ... important part of retinal cell differentiation during the developmental stage. ... replace any lost retinal cells by using the stem cell ...
... Positron emission tomography (PET) scan images can successfully detect ... the cognitive behavior therapy in patients. Researchers behind the ... therapy can bring about changes in the brain chemical ... like those suffering from bulimia nervosa. ,Cognitive ...
... to malaria//. The people with a specific type of hemoglobin ... color — are less prone to severe malaria. In a ... impairs the ability of malaria parasites to cause disease symptoms. ... a major global killer that preys especially on young children ...
... Taking a sample of the mouth rinse solution can be ... are successful in patients. ,Oral mouth rinse of the ... which are the white blood cells that fight infection in ... mouth washes to counteract the problem of mucositis that may ...
... published in the Archives of Diseases in Childhood has shown ... have behavioural problems at age 14. Obesity starts from childhood ... risk of diabetes and cardiovascular disease in adulthood. But studies ... have been inconsistent. ,So the present study was ...
Cached Medicine News:Health News:Pollution Free Hydrogen based fuel for Energy 2Health News:Pollution Free Hydrogen based fuel for Energy 3Health News:Scientists Unveil Mechanism Behind Resistance to Severe Malaria 2Health News:Scientists Unveil Mechanism Behind Resistance to Severe Malaria 3
(Date:7/31/2015)... SAN DIEGO , July 31, 2015 ... Eisai Co., Ltd. (Headquarters: Tokyo , ... Halozyme Therapeutics, Inc. (Headquarters: San Diego, California ... , "NASDAQ: HALO") have signed a clinical collaboration agreement ... , "eribulin") in combination with Halozyme,s investigational drug PEGPH20 ...
(Date:7/31/2015)... HYDERABAD, India , July 31, 2015 /PRNewswire/ ... Billing and CRM solutions for video, data and cloud ... (PoC) with a leading pharma giant for Internet ... managing different IoT applications offered on subscription model. ... Pharma giant is striving for business ...
(Date:7/30/2015)... , July 30, 2015  ResMed ... has signed a definitive agreement to acquire ... non-invasive ventilation and sleep-disordered breathing medical devices ... innovation and market reputation in China, combined with ResMed,s global leadership in sleep ... in China suffering ...
Breaking Medicine Technology:Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... 3, 2012  ECRI Institute ( www.ecri.org ), an ... improving patient care, listed 10 health technology issues ... lists for 2012. The just-released list takes into ... and regulatory pressures currently facing healthcare executives. ...
... the New Year begins, and healthy resolutions are made, ... Americans to clean out their medicine cabinets. Pharmacists recommend ... to dispose of all the unused and expired medications ... year tradition will help keep everyone safe and healthy. ...
Cached Medicine Technology:ECRI Institute Puts 10 Technology Issues on its 2012 Watch List for Hospital Executives 2ECRI Institute Puts 10 Technology Issues on its 2012 Watch List for Hospital Executives 3ECRI Institute Puts 10 Technology Issues on its 2012 Watch List for Hospital Executives 4Best New Year's Resolution From Your Pharmacist: Toss Old Medication 2Best New Year's Resolution From Your Pharmacist: Toss Old Medication 3
... Interference Screws. Optimal screw ... graft selection options. Robust ... deformation, and chamfered screw ... atraumatic tissue fixation. Features ...
Cannulated Interference Screws...
... mm Mini-TrueView Arthroscopes,Based on the TrueView II ... fibre optic telescopes for small joint arthroscopy ... fully autoclavable and very durable thanks to ... the new telescope class means bright images, ...
Stryker Endoscopy offers a wide variety of small-joint arthroscopes that produce a brilliant high-resolution image without sacrificing Stryker's ultra-high tip durability....
Medicine Products: