Navigation Links
UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
Date:1/31/2008

Researchers at UCLAs Jonsson Cancer Center have discovered biomarkers that predict which patients with advanced non-small cell lung cancer will respond to a combination treatment of the anti-inflammatory drug Celebrex and the growth factor receptor blocker Tarceva.

The findings, published in the Feb. 1, 2008 issue of the Journal of Thoracic Oncology, may help oncologists personalize treatment, prescribing drugs they know patients will respond to and sparing them from therapies that wont work. Both drugs are taken in pill form once a day and result in fewer side effects than conventional treatments such as chemotherapy.

If the findings are confirmed in further studies, the personalized drug combination would offer an alternative therapy in a disease population in which new, more effective treatments are needed, said Dr. Steven Dubinett, a professor of pulmonary and critical care medicine and senior author of the study. This year alone, more than 213,000 Americans will be diagnosed with lung cancer. Of those, more than 160,000 will die.

We need good predictors of response to targeted therapy in lung cancer so individual patients receive the specific therapy that targets the particular molecular abnormalities of their tumors, said Dubinett, who also serves as director of the cancer centers Specialized Program of Research Excellence (SPORE) in lung cancer.

The findings grew out of a Phase I dose-escalation study of the drug combination in a small group of patients who had failed all other treatment options. The early phase study resulted in more patient responses than expected in people with advanced lung cancer, the most deadly stage of the disease. About 50 percent of patients in the study had tumors that decreased in size by more than 30 percent or had tumors that did not grow, a state called stable disease that is considered a positive outcome.

UCLA researchers studied tumor, blood and urine samples from the pa
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn researchers discover new target for preventing and treating flu
2. Researchers investigate links between prostate, cadmium, zinc
3. New nanotube findings by Stanford researchers give boost to potential biomedical applications
4. Researchers Map Paths Governing Neuron Function
5. Cold Spring Harbor Laboratory researchers race against time to save Tasmanian devils
6. Researchers at Peoria Pulmonary Associates to study airway bypass procedure for emphysema
7. Pain medicine meeting unites top researchers and clinicians
8. Researchers identify brains eureka circuitry
9. Researchers find relief for chronic pain
10. Researchers propose consumers buy yearly drug licenses as new way to pay for prescriptions
11. Pros, cons of drug proven to prevent prostate cancer should be considered, researchers recommend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... MillionaireCasket.com is a professional supplier of funeral products. According to ... well in the global market. Recently, the company has announced ... a special offer for all the newly released items. ... caskets are made with superb materials. As is commonly noted, ... respect to the departed saint. MillionaireCasket.com is always here to ...
(Date:7/13/2014)... 13, 2014 Intraocular Lens (IOL) Market: ... 2013 - 2019 , Intraocular lens (IOL) is inserted ... or cataracts. The lenses are inserted inside the eye, ... intraocular lens replaces the focusing power of natural lens. ... lens to deliver the light focusing function which was ...
(Date:7/13/2014)... Victorian Hotel has recently announced that ... of bikes for its "Cycle the City" program, which ... tour the area using a rental bicycle, available for ... to call Vancouver home, as it is a city ... picturesque journeys through the countryside. Vancouver hotel rooms often ...
(Date:7/13/2014)... additives are chemicals, which are added to various fuels ... on, in order to enhance their performance. Fuel additives ... by fuels and improving the combustion properties of fuels. ... scale in the long run, but, in the short ... products. , The various fuel additive types include deposit ...
(Date:7/13/2014)... The Pearland, Texas location of The Little Gym, a ... to 12 years of age that offers everything from gymnastics, ... Summer Camps, is now under new ownership. , Kevin Berry ... spending over six years at The Little Gym of Bellaire ... Berry has over ten years of experience working with children, ...
Breaking Medicine News(10 mins):Health News:Brand New Cherry Caskets Unveiled By China Casket Supplier MillionaireCasket.com 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2
... ... received its first batch of Spirits Bay Manuka Honey tested for activity using ... is a registered trademark of the University of Waikato, home of the Honey ... of manuka honey. Produced by a Maori-owned apiary in a remote area of ...
... ... employee wellness programs , ... GA (Vocus) April 7, 2010 -- R. Shane Jackson, president of LocumTenens.com and ... for Health Transformation,s (CHT) first member meeting of 2010, which took place on March 25 ...
... poor people have higher death rates than rich within first decade ... more likely to die within five to 10 years after heart ... 15,156 white men, 6,932 white women, 678 black men and 564 ... and 2005 and found that the poorest patients were 19 to ...
... , ... today released version 4.3 of Replay, the award-winning, next generation backup and disaster recovery ... ... 4.3 of Replay, the award-winning, next generation backup and disaster recovery software solution. ...
... a means of heterosexual interaction on university campuses, more women ... women rate hooking up above dating. Both genders however perceive ... Bradshaw from James Madison University in Virginia, US, and colleagues ... hook up or to date, as well as the perceived ...
... vaccine were at higher risk, study found, but that ... (HealthDay News) The traditional seasonal flu vaccine may ... swine flu, according to the results of four new ... researchers used an ongoing sentinel monitoring system to assess ...
Cached Medicine News:Health News:Koru Naturals Becomes the First U.S. Company to Import Molan Gold Standard Manuka Honey 2Health News:R. Shane Jackson Selected as Panelist for Center for Health Transformation Member Meeting 2Health News:R. Shane Jackson Selected as Panelist for Center for Health Transformation Member Meeting 3Health News:Poor More Likely to Die Following Heart Surgery 2Health News:De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V 2Health News:De-Duplication, Compression and No Double Backups Required: AppAssure Releases the Fastest and Most Scalable Backup & Recovery Solution for Microsoft Hyper-V 3Health News:Hooking up or dating: Who benefits? 2Health News:Did 'Regular' Flu Shot Up Risks for H1N1 Flu? 2
(Date:7/11/2014)... , July 11, 2014 ... visitors to Safety & Health Expo 2014 ... the move to London ... management attending exhibition.     ... http://photos.prnewswire.com/prnh/20140711/696892-a )      ...
(Date:7/10/2014)... NEWS, Virginia , 11. Juli ... Hersteller von Kameras für die molekulare ... (MBI/BSGI), hat heute die CE-Zulassung für ... dem CE-Zeichen kann Dilon das Produkt ... Vertriebsbereich auf den Großteil der europäischen ...
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon ... in advanced memory and analog IC solutions, today announced ... Thursday, July 24, 2014, at 7:00 a.m. Pacific Time ... results for the fiscal 2014 third quarter ended June ... via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time ...
Breaking Medicine Technology:UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2
... The Detroit Medical Center (DMC) Cardiovascular Institute (CVI) ... to successfully open a patient,s blocked artery with a ... drill" to painlessly remove the plaque buildup which causes ... – conducted Wednesday by CVI Director of Endovascular Medicine ...
... HistoRx, the leader in quantitative immunohistochemistry, advances ... recent issuance of US patents covering key features ... results.  The U.S. Patent and Trademark Office has ... for standardization of digital microscopy instruments, methods required ...
Cached Medicine Technology:DMC Cardiovascular Institute Physician is First in Michigan to Use New "Arterial Drill" Catheterization Technique to Remove a Major Blockage 2DMC Cardiovascular Institute Physician is First in Michigan to Use New "Arterial Drill" Catheterization Technique to Remove a Major Blockage 3HistoRx Earns Two Additional Patents on Standardization of Results from Digital Pathology Instruments 2HistoRx Earns Two Additional Patents on Standardization of Results from Digital Pathology Instruments 3
The Freedom Clear® LS Long Seal is a 100% latex-free, self-adhering, one piece catheter with an ultra-thin sheath for everyday wear. Its long seal provides added security....
Freedom Clear® SS Sport Sheath is a 100% latex-free, self-adhering, one piece catheter with an ultra-thin sheath designed for everyday wear. Its brief sheath minimizes roll at the base of the p...
The UltraFlex® all silicone self-adhering male external catheter is 100% latex-free and eliminates the risk of latex-related skin irritations. This breathable catheter promotes healthy skin and i...
... all-silicone Foley catheters eliminate patient exposure ... catheter designs. As an inert, toxin-free ... a safe, dependable Foley catheter. Unlike ... catheters will not leach chemicals or ...
Medicine Products: