Navigation Links
UCLA researchers design nanomachine that kills cancer cells
Date:4/1/2008

Researchers from the Nano Machine Center at the California NanoSystems Institute at UCLA have developed a novel type of nanomachine that can capture and store anticancer drugs inside tiny pores and release them into cancer cells in response to light.

Known as a "nanoimpeller," the device is the first light-powered nanomachine that operates inside a living cell, a development that has strong implications for cancer treatment.

UCLA researchers reported the synthesis and operation of nanoparticles containing nanoimpellers that can deliver anticancer drugs March 31 in the online edition of the nanoscience journal Small.

The study was conducted jointly by Jeffrey Zink, UCLA professor of chemistry and biochemistry, and Fuyu Tamanoi, UCLA professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics program at UCLA's Jonsson Comprehensive Cancer Center. Tamanoi and Zink are two of the co-directors for the Nano Machine Center for Targeted Delivery and On-Demand Release at the California NanoSystems Institute.

Nanomechanical systems designed to trap and release molecules from pores in response to a stimulus have been the subject of intensive investigation, in large part for their potential applications in precise drug delivery. Nanomaterials suitable for this type of operation must consist of both an appropriate container and a photo-activated moving component.

To achieve this, the UCLA researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that can oscillate between two different conformations upon light exposure. Operation of the nanoimpeller was demonstrated using a variety of human cancer cells, including colon and pancreatic cancer cells. The nanoparticles were given to human cancer cells in vitro and taken up in the dark. When light was directed at the particles, the nanoimpeller mechanism
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers study why high school boys dodge Phys Ed
2. Researchers Successfully Test Ebola Vaccines
3. Researchers identify a gene responsible for cases of Lou Gehrigs disease
4. Researchers identify a gene responsible for Lou Gehrigs disease
5. UCLA researchers examine human embryonic stem cell genome
6. Researchers Create Protective Sac for Growing Stem Cells
7. UC Irvine researchers present latest findings at emergency medicine forum
8. Researchers urge ethics guidelines for human-genome research
9. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
10. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
11. Researchers Gain Insights Into On-Off Switch for Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... Insuranceautoquote.info has released a new blog post explaining ... , Clients can review important auto insurance quotes ... provides important advantages for clients who need affordable financial ... not have coverage for their vehicles can purchase a ... hour. Many agencies offer important discounts and drivers can ...
(Date:4/18/2015)... April 18, 2015 In the past ... couple of changes. , "We had to run maintenance ... needed changes," said Jennifer Ramirez, the PR Director. "It ... to say that we are back on track after ... the process of changing phone systems which has not ...
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... 2015 ERGO-Pedic Products, LLC, which produces ... new products to help a broader range of people ... are the second most common visitors to doctors. , ... specifically to help relieve sitting pain. Then, only a ... of happy customers later, we began getting questions from ...
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
Breaking Medicine News(10 mins):Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Seat Cushion Company Credits Customer Driven Design For Two New Products 2Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2
... The California Nurses Association/National Nurses Organizing Committee ... labor movement as the next President of American ... , Trumka, the current AFL-CIO Secretary Treasurer, ... today, leaders of the 86,000 member CNA/NNOC, the ...
... 9 GeoFitness,s main goal has been to get Americans ... products and curriculum. Their ability to provide solutions to ... learning has provided unprecedented growth. The name change to ... to include 3 distinct product lines which can interact to ...
... A Key to Lowering Healthcare Costs and Expanding Viability and ... June 9 Health professionals and patients alike ... aid in stabilizing mounting healthcare costs by increasing compliance. ... the U.S. Food and Drug Administration for its expanded, flexible ...
... Miley Cyrus at the 20th Annual A Time For Heroes ... Pediatric AIDS Foundation , , LOS ANGELES, June 9 ... the 20th annual A Time For Heroes Family Picnic, held ... Glaser Pediatric AIDS Foundation. More than 80 of Hollywood,s best-known ...
... , DUBLIN, June 9 ... provider of outsourced development services to,the pharmaceutical, biotechnology and ... strategic partnership with Eli Lilly and,Company (NYSE: ... set up and,monitoring in Europe for Lilly managed studies. ...
... ... the launching of their new, pharmaceutical website, featuring an extensive selection of medications for ... ... pharmacy stocking popularly sold medications, with a particular emphasis on Erectile Dysfunction treatments. ...
Cached Medicine News:Health News:Nation's Largest RN Union Endorses Trumka to Lead Labor as President of AFL-CIO 2Health News:GeoFitness, Inc. is Now GeoMotion Group, an Innovative and Fast Growing Learning and Fitness Company for All Ages 2Health News:MedApps Receives FDA Clearance on a New Way to Bring Cost-Effective Remote Health Monitoring to More People 2Health News:Celebrities Come Together to Fight Pediatric AIDS 2Health News:Celebrities Come Together to Fight Pediatric AIDS 3Health News:ICON Selected to Manage Lilly Clinical Trial Site Set Up and Monitoring in Europe 2Health News:Pro-Medics Launches Its New Line of Male Impotence Treatment Products 2
(Date:4/17/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vrd3bd/mammography ... Equipment - Global Strategic Business Report" report to ... markets for Mammography Equipment in US$ Thousands by the ... Equipment. The report provides separate comprehensive analytics for the ... , Europe , ...
(Date:4/17/2015)... , April 17, 2015 Today, the ... 13 employees from 12 biopharmaceutical companies as "We ... in policy advocacy and community service. ... Champion Awards were created by the biopharmaceutical industry ... in their careers, but have also shown an ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/256szd/corporate ) ... of Pharma in 2014 - a Perspective of Mental ... their offering. For the first time, in ... reputation of the pharmaceutical industry held by patient groups ... of patient organisations representing all therapy areas. ...
Breaking Medicine Technology:Mammography Equipment (Analog & Digital) Market 2015-2020 - Global Strategic Business Report: Breast Imaging Screening Programs Push Sales 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3
... and Exercise-Induced ... Bronchoconstriction -, PLYMOUTH MEETING, Pa., March ... partner,MedImmune, has initiated its fourth phase 2a clinical trial of MEDI-528, ... clinical trial is designed to assess the,potential of MEDI-528 in patients ...
... Peptimmune, Inc. a privately,held biotechnology company, announced that ... the safety, tolerability, pharmacokinetics and,pharmacodynamics of PI-2301, a ... and other autoimmune diseases., The Phase I ... involved 56 healthy volunteers who received the drug ...
Cached Medicine Technology:Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma 2Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma 3Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma 4Peptimmune Completes Phase I Study with a Novel Peptide Copolymer for the Treatment of Multiple Sclerosis 2
... The Ace Align is an external ... open fractures of the femur, tibia, humerus ... closed fractures where external fixation is the ... consideration. , ,The Ace Align is fully ...
The DFS Standard Fixator advantages include a highly adjustable system, modular compression/distraction, versatile central body component that provides 360 of rotation, and a positive locking mechani...
The Adjustable Large Fixator is a one-piece fixator with a radiolucent body. It has a multifunctional design pivoting pin clamp for use in ankle or tibial plateau fractures....
Provides basic reduction capabilities for angulation, rotation and length. Ball joint design offers fracture reduction in all planes....
Medicine Products: