Navigation Links
UCLA researchers design nanomachine that kills cancer cells
Date:4/1/2008

Researchers from the Nano Machine Center at the California NanoSystems Institute at UCLA have developed a novel type of nanomachine that can capture and store anticancer drugs inside tiny pores and release them into cancer cells in response to light.

Known as a "nanoimpeller," the device is the first light-powered nanomachine that operates inside a living cell, a development that has strong implications for cancer treatment.

UCLA researchers reported the synthesis and operation of nanoparticles containing nanoimpellers that can deliver anticancer drugs March 31 in the online edition of the nanoscience journal Small.

The study was conducted jointly by Jeffrey Zink, UCLA professor of chemistry and biochemistry, and Fuyu Tamanoi, UCLA professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics program at UCLA's Jonsson Comprehensive Cancer Center. Tamanoi and Zink are two of the co-directors for the Nano Machine Center for Targeted Delivery and On-Demand Release at the California NanoSystems Institute.

Nanomechanical systems designed to trap and release molecules from pores in response to a stimulus have been the subject of intensive investigation, in large part for their potential applications in precise drug delivery. Nanomaterials suitable for this type of operation must consist of both an appropriate container and a photo-activated moving component.

To achieve this, the UCLA researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that can oscillate between two different conformations upon light exposure. Operation of the nanoimpeller was demonstrated using a variety of human cancer cells, including colon and pancreatic cancer cells. The nanoparticles were given to human cancer cells in vitro and taken up in the dark. When light was directed at the particles, the nanoimpeller mechanism
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers study why high school boys dodge Phys Ed
2. Researchers Successfully Test Ebola Vaccines
3. Researchers identify a gene responsible for cases of Lou Gehrigs disease
4. Researchers identify a gene responsible for Lou Gehrigs disease
5. UCLA researchers examine human embryonic stem cell genome
6. Researchers Create Protective Sac for Growing Stem Cells
7. UC Irvine researchers present latest findings at emergency medicine forum
8. Researchers urge ethics guidelines for human-genome research
9. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
10. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
11. Researchers Gain Insights Into On-Off Switch for Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... September 19, 2014 Lipitor lawsuits ( ... some patients to develop Type 2 diabetes continue to ... in U.S. District Court, District of South Carolina, Bernstein ... on September 12, 2014, discovery is underway and moving ... noted that Pfizer, Inc., the manufacturer of Lipitor, has ...
(Date:9/19/2014)... In partnership with Raw Beauty NYC, OC healthcare ... project’s social media efforts. StudioPMG is honored to be a ... of beauty as it applies to disabled women. , ... Baer and Vanessa Silberman, who wanted to create a photo ... Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen later joined ...
(Date:9/19/2014)... campus of Mayo Clinic have discovered a defect in ... overproduction of toxic protein in the brains of ... communication between neurons both significant contributors to this ... issue of Neuron , offers the ... rejuvenate or rescue this pathway," says the study,s lead ...
(Date:9/19/2014)... 2014 (HealthDay News) -- More states are passing legislation ... to use for any child having a severe allergic ... "anaphylaxis," an allergic reaction that can lead to throat ... and even death. In people with severe ... nuts, insect venom or certain drugs, anaphylaxis can occur ...
(Date:9/19/2014)... difficult to study with X-ray crystallography, not least because ... crystallize, but also because their very nature means they ... structure can be obtained it is often of low ... domains that sometimes create more puzzles than they solve. ... D70, 2241-2255; doi: 10.1107/S1399004714016496 ] , Now, Gunnar ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 3Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:Mayo researchers reveal pathway that contributes to Alzheimer's disease 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 3Health News:A refined approach to proteins at low resolution 2Health News:A refined approach to proteins at low resolution 3
... soon connect every nook and corner of its vast ... social services to people, especially those living in far-flung ... of EDUSAT is being expanded across the country while ... the Indian Space Research Organisation (ISRO)," said S. Krishnamurthy, ...
... taken one more step towards a successful womb transplant. // ... wombs removed and then reconnected, Swedish scientists say. ... transplant in the sheep - where the same womb is ... that half the sheep in the study developed fatal complications ...
... Haryana government Tuesday proposed a medical university in the state ... ,Addressing the silver jubilee celebrations of the Government Dental ... Hooda said that setting up a medical university would help ... ,Hooda said that paucity of funds would ...
... researchers, children who report in with a head injury are twice ... //with children who sprain their ankle or wrist, instead. , ... which was published in the journal Pediatrics: “They were almost twice ... kids who had a sprained ankle or wrist." , ...
... Seventy percent of pediatricians rely on patients' family members ... a study by Johns Hopkins School of Medicine, the ... author Dennis Kuo, a general pediatrics fellow at Johns ... from the American Academy of Pediatrics and found that ...
... risk of breast cancer if they eat red meat, one more study ... of red meat had a 56% increased risk compared with those who ... meat, such as bacon, sausages, ham or pies, had a 64% greater ... University of Leeds study features in the British Journal of Cancer. ...
Cached Medicine News:Health News:Satellites Set to Play Good Samaritans in India 2Health News:Satellites Set to Play Good Samaritans in India 3Health News:Womb Transplant Pregnancy Success 2Health News:When ‘Humpty Dumpty’ Falls Aga 2Health News:Red Meat Increases Breast Cancer Risk 2
(Date:9/19/2014)... Research and Markets ... of the "Global Gynecological Devices Market ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... wide categories based on their operations. These ... different gynecological conditions that affect the female ...
(Date:9/19/2014)... TRIANGLE PARK, N.C. , Sept. 19, 2014 ... focused on cloud-based drug design and development, partnering ... The company,s mission is to design new drugs ... 1 and 2 partners to further their development. ... its portfolio investments. To support this business model, ...
(Date:9/19/2014)... , Sept. 19, 2014 The American Association ... Medical Design and Manufacturing has joined the AAHomecare Corporate ... Harvey Diamond have been actively involved in ... as it has quickly grown into a major global ... like Drive allows AAHomecare to increase efforts on behalf ...
Breaking Medicine Technology:Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2
... Inc. (NASDAQ: DCTH ) announced today that management ... Conference on Tuesday, August 16, 2011 at 2:25 P.M. ET ... an overview of the Company,s business strategy and recent corporate ... invitation only. Delcath will offer a live audio webcast of ...
... 10, 2011 Leading events organizers UBM Canon ... (LSE: UBM), today announced a virtual conference event which will examine ... chain, counterfeit drugs. Titled ,Pharmaceutical Track & Trace Authentication: The Fight ... from 6:00 to 14:00 New York time, 12:00 to 20:00 Paris ...
Cached Medicine Technology:Delcath to Present at the Wedbush 2011 Life Sciences Conference on August 16, 2011 2Delcath to Present at the Wedbush 2011 Life Sciences Conference on August 16, 2011 3UBM Canon Introduces a Compelling New Virtual Conference Focused on Track & Trace Solutions for the Pharma Sector 2UBM Canon Introduces a Compelling New Virtual Conference Focused on Track & Trace Solutions for the Pharma Sector 3
Sprint Quattro Secure™ is a Steroid-Eluting, True Bipolar, Active Fixation ICD Lead....
The Livewire steerable electrophysiology catheter is uniquely designed with an ergonomic handle and patented steering mechanism to provide smooth, precise catheter tip movement, even during lengthy e...
The Livewire cannulator offers improved access to the coronary sinus by combining the ergonomic Livewire steering mechanism with numerous specialized features....
Trilogy Pacemakers incorporates the clinically proven Omniscence™ accelerometer sensor with it's automatic alogorithms. The Trilogy family of pacemakers feature an array of products for bradyar...
Medicine Products: