Navigation Links
UCLA researchers design nanomachine that kills cancer cells
Date:4/1/2008

Researchers from the Nano Machine Center at the California NanoSystems Institute at UCLA have developed a novel type of nanomachine that can capture and store anticancer drugs inside tiny pores and release them into cancer cells in response to light.

Known as a "nanoimpeller," the device is the first light-powered nanomachine that operates inside a living cell, a development that has strong implications for cancer treatment.

UCLA researchers reported the synthesis and operation of nanoparticles containing nanoimpellers that can deliver anticancer drugs March 31 in the online edition of the nanoscience journal Small.

The study was conducted jointly by Jeffrey Zink, UCLA professor of chemistry and biochemistry, and Fuyu Tamanoi, UCLA professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics program at UCLA's Jonsson Comprehensive Cancer Center. Tamanoi and Zink are two of the co-directors for the Nano Machine Center for Targeted Delivery and On-Demand Release at the California NanoSystems Institute.

Nanomechanical systems designed to trap and release molecules from pores in response to a stimulus have been the subject of intensive investigation, in large part for their potential applications in precise drug delivery. Nanomaterials suitable for this type of operation must consist of both an appropriate container and a photo-activated moving component.

To achieve this, the UCLA researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that can oscillate between two different conformations upon light exposure. Operation of the nanoimpeller was demonstrated using a variety of human cancer cells, including colon and pancreatic cancer cells. The nanoparticles were given to human cancer cells in vitro and taken up in the dark. When light was directed at the particles, the nanoimpeller mechanism
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers study why high school boys dodge Phys Ed
2. Researchers Successfully Test Ebola Vaccines
3. Researchers identify a gene responsible for cases of Lou Gehrigs disease
4. Researchers identify a gene responsible for Lou Gehrigs disease
5. UCLA researchers examine human embryonic stem cell genome
6. Researchers Create Protective Sac for Growing Stem Cells
7. UC Irvine researchers present latest findings at emergency medicine forum
8. Researchers urge ethics guidelines for human-genome research
9. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
10. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
11. Researchers Gain Insights Into On-Off Switch for Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Overeating is common during the holidays, but there are strategies ... "Don,t arrive at a party hungry. It may seem ... attending a party, but deprivation leads to hunger, and hunger ... Hospital in Mount Kisco, N.Y., said in a hospital news ... and even to have a snack before attending a party ...
(Date:12/25/2014)... Thompson HealthDay Reporter WEDNESDAY, ... in on a "fountain of youth" drug that can delay ... adults, a new study suggests. Seniors received a significant ... targets a genetic signaling pathway linked to aging and immune ... The experimental medication, a version of the drug rapamycin, ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Thousands of ... move forward in a number of multidistrict litigations currently ... Virginia, Bernstein Liebhard LLP reports. According to an Order ... to convene a Joint Status Conference in all of ... Parties have been directed to submit a proposed agenda ...
(Date:12/25/2014)... 25, 2014 Plugin creators from Pixel ... A fully customizable business presentation tool made specifically for ... ProFire 5k business tool, users can now display their ... of Pixel Film Studios. “ProFire 5k gives users a ... add professionalism to a presentation” , Pixel Film Studios ...
(Date:12/25/2014)... Each year trauma accounts for approximately 42 ... across the nation (according to the Centers for ... Hospital Ambulatory Medical Care Survey collected data from ... They estimated that there were between 3.5 and 4.4 ... diagnosis of broken bone or fracture. , When ...
Breaking Medicine News(10 mins):Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... (HealthDay News) -- More patients and families are using Facebook ... do improves the chances of obtaining a donor organ, a ... in Maywood, Ill., examined 91 Facebook pages that were seeking ... that 12 percent of the pages reported receiving a kidney ...
... Reporter , WEDNESDAY, May 30 (HealthDay News) -- The health ... but new research may add another condition to this list: ... lymph nodes in the groin area. Lymphedema in the ... removal of or damage to the lymph nodes. A blockage ...
... -- Advancements in human genetic research could lead ... protect against the misuse of people,s genetic data, the ... policy recommendations, including U.S. government oversight of genetic tests ... While discoveries in recent years -- such as the ...
... (HealthDay News) -- Scientists who were the first to fully ... step toward improving its yield, nutrition, disease resistance, taste and ... "Heinz 1706" tomato and found that it has about 35,000 ... the tomato -- whether it,s taste, natural pest resistance or ...
... , EVANSTON, Ill. --- American parents may want to ... their children from everyday germs. A new Northwestern ... evidence of chronic low-grade inflammation -- associated with diseases ... In contrast, about one-third of adults in the United ...
... busier than ever, but Case Western Reserve University psychologists ... fact, it appears to have increased. Psychologists ... when they analyzed 14 play studies that Russ conducted ... But as they report in "Changes in Children,s Play ...
Cached Medicine News:Health News:More Families Seek Kidney Donations on Facebook 2Health News:Obesity May Raise Odds for Painful Leg Condition 2Health News:Brave New World of Genetics Requires Safeguards, Experts Say 2Health News:Scientists Map the Tomato's Genome 2Health News:Understanding the links between inflammation and chronic disease 2Health News:Understanding the links between inflammation and chronic disease 3Health News:Despite less play, children's use of imagination increases over 2 decades 2
(Date:12/24/2014)... , Dec. 23, 2014 Echo Therapeutics, ... device company focused on skin permeation, continuous glucose ... Scott W. Hollander has been appointed Chief ... has more than 20 years of experience in ... and most recently served as Vice President, Business ...
(Date:12/24/2014)... SAN DIEGO , Dec. 23, 2014 ResMed ... a significant patent infringement action against Chinese medical device manufacturer ... Commission (ITC) ruled today that BMC,s masks listed below infringe ... advertising, or selling these masks in the United ... , iVolve N2 nasal mask , Willow nasal pillows ...
(Date:12/24/2014)... 23, 2014   Synageva BioPharma Corp. ... developing therapeutic products for rare disorders, today announced ... the Marketing Authorization Application (MAA) for sebelipase alfa ... company,s request for accelerated assessment, which has the ... The MAA, and the Biologics ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... WELLESLEY HILLS, Mass. , May 10 ... Benefit of Creditors of Epix Pharmaceuticals, Inc. ("Epix"), announced today ... imaging agent, which will be auctioned on May 28, ... sale of non-MRI imaging agents developed and/or sold by a ...
... , PHILADELPHIA , May 10 Even with a ... region are struggling to make ends meet. This spring, Shire Pharmaceuticals ... with its third annual BIG GIVE regional donation drive to benefit ... , ...
Cached Medicine Technology:Epix Pharmaceuticals, Inc. Announces Additional Information Concerning the May 28, 2010 Auction Sale of EP-2104R MRI Imaging Agent 2Area Residents Can Give a Little, Help A Lot at Shire's BIG GIVE 2
... FlexSure HP is a visually read, qualitative ... to H. pylori, a bacterium that grows ... peptic ulcer disease and some gastric cancers. ... whole blood or serum samples, provides the ...
Rapid Infectious Mononucleosis Heterophile Antibody (IgM) Test...
... Whole Blood Test is a rapid ... of IgM antibodies specific to infectious ... This test kit can be used ... IM in patients with clinical symptoms ...
... available point-of-care diagnostic test that can reliably ... A and B. The test uses a ... that assists viral replication by promoting the ... The ZstatFlu substrate is labeled with a ...
Medicine Products: