The discovery of PDV-IBS could mean better attention to patients complaining of symptoms after diverticulitis, symptoms that up until now may have been dismissed by physicians. Spiegel said the PDV-IBS "Patients often report ongoing IBS symptoms after the diverticulitis has long passed, and this study supports their beliefs and introduces a new diagnosis," Spiegel said. "If doctors recognize this, they may take the symptoms more seriously and manage them actively, just as they can manage IBS actively with various new drugs on the market and currently in development."
More than 1,000 patient records from the West Los Angeles Veteran's Affairs Medical Center were examined for the two-year study, including patients that had suffered acute diverticulitis and another group of patients that did not have it. The groups were matched for age and sex and had similar comorbidities, or other existing health problems. The groups were followed for many years as UCLA researchers tracked the differences in IBS diagnoses and mood disorders.
"This study expands our understanding a little bit about what might cause IBS. It's such a common condition and there may be different flavors," Spiegel said. "We've now added a new flavor to the menu, a new risk factor for developing IBS. By learning more, we might be able to expand the therapies we can use on these patients."
The study was funded by Shire Pharmaceuticals.
"Our findings support the evolving paradigm of diverticular disease as a chronic illness- not merely an acute condition marked by abrupt complications. Far from a self-limited episode, acute diverticulitis may become a chronic disorder in some patients," the study states. "Diverticulitis is correlated with not only chronic IBS symptoms, but also long-term emotional distress beyond the event itself. Awareness of this possible risk is important because persistent, untreated gastrointe
|Contact: Kim Irwin|
University of California - Los Angeles Health Sciences