Navigation Links
UCLA research team selected to present original epilepsy research on Capitol Hill
Date:4/28/2014

A graduate student in Semel Institute for Neuroscience and Human Behavior, and two of his undergraduate trainees, were selected by the Council on Undergraduate Research to present their original research on Capitol Hill in Washington, D.C., on Tuesday.

Wesley Kerr, whose graduate studies will be completed in the UCLA Department of Biomathematics, and his trainees, Akash Patel and Sarah Barritt, will present their poster entitled "Computer-Aided Diagnosis of Epilepsy Using Clinical Information" outlining advances in the use of computational machine learning to help clinicians detect and diagnose epilepsy correctly.

"This is very exciting," Kerr said of the selection to participate. "It's always nice to get exposure for our work."

The Posters on the Hill exhibit typically picks just one or two research projects per state to participate in the prestigious event, said Mark Cohen, Kerr's faculty advisor and a professor-in-residence of psychiatry in the Semel Institute for Neuroscience and Human Behavior.

"A large fraction of patients with seizure disorder are misdiagnosed and treated inappropriately," Cohen said. "As such treatments carry their own risks and negative side effects, their research could positively affect the lives of millions of Americans."

The goal of Kerr's team was to estimate the probability of epilepsy versus non-epileptic seizures based on the historical factors reported by the patient to their neurologist.

Distinguishing between epileptic and non-epileptic seizures is a challenge, Kerr said. On average, the time from the first seizure to the diagnosis of non-epileptic seizures is seven years. In the meantime, a majority of those patients are misdiagnosed with epilepsy and treated inappropriately with anti-epileptic medications.

"This can expose patients to serious, and potentially fatal, side effects," Kerr said. "One of our laboratory's goals is to create an automated system that can aid physicians in distinguishing patients with epileptic and non-epileptic seizures."

Kerr and his team accomplished this by inspecting outpatient clinical notes from patients with medication-resistant seizure disorder, who were later diagnosed as having epilepsy or non-epileptic seizure disorder, using the gold standard diagnostic assessment, 72- hour in-patient closed circuit video-electroencephalography (VEEG) monitoring.

Using a combination of the known risk factors for epilepsy and non-epileptic seizures reported in 228 clinical notes the team examined, their algorithm achieved a diagnosis accuracy of 65%. While at first glance this may appear low, it is comparable to the accuracy of neurologists prior to VEEG monitoring. In this work, they used a machine learning method known as a "decision tree."

"The structure of our decision tree also provided meaningful information about the interpretation of each risk factor in each patient. For example, the risk factors for non-epileptic seizures may not be the same for women and men," Kerr said. "This work may help diagnose, and thereby more effectively treat, patients that are in need."

In addition to serving patients with seizure disorder, the computer-aided diagnostic methods developed by Kerr and his team may be applicable to the diagnosis of other maladies in the future.

As part of their trip, Patel, Barritt and Kerr will take meetings in the offices of California state senators and representatives. They will use this forum to emphasize the importance of appropriate diagnosis in epilepsy and the academic environment at UCLA that made this research possible.


'/>"/>
Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Related medicine news :

1. Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
2. Indiana University researchers gauge the toll of trampoline fractures on children
3. AGA showcases its commitment to improving the pipeline of minority researchers
4. Researchers identify potential new strategy to treat ovarian cancer
5. NYU Steinhardt researchers to study why male millennials risk HIV transmission
6. Research shows strategic thinking strengthens intellectual capacity
7. Researchers generate immunity against tumor vessel protein
8. Researchers at LSTM part of the international team to sequence the tsetse genome
9. Oxygen diminishes the hearts ability to regenerate, researchers discover
10. Georgia State researcher gets $2.83 million grant to develop drugs for RSV infection
11. Finnish team of researchers finds a mutation in a tumor of the jaw
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCLA research team selected to present original epilepsy research  on Capitol Hill
(Date:1/24/2017)... ... January 24, 2017 , ... ... semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under Armour ... in 2017. The entrepreneurs will showcase their businesses on February 6, 2017, at ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... today that its annual Solutions Series of webinars will start January 31 with ... discussing a number of current health and benefits topics, including employee engagement, pricing ...
(Date:1/24/2017)... ... January 24, 2017 , ... His message has been heard by more than ... End Distracted Driving , Joel Feldman, has reached his biggest national audience yet: the ... of the top newspapers in circulation in the country, and he hopes it will ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... Center ... 21st century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at ... center - as its Hispanic Leader of the Month. City of Hope is committed ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... is the focus of a new report from the Frank Hawkins Kenan ... School. , Influential business leaders, academics and policy makers identified concrete solutions at ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... Aptuit, LLC, hat heute den ... Massachusetts General Hospital (MGH) unter Leitung von Dr. ... Identifizierung und Validierung neuartiger Targets in gramnegativen Bakterien.  Aptuit ... von Antibiotika bei der Behandlung schwerer Infektionen entgegenwirken können. ... ...
(Date:1/24/2017)... -- Laboratory Markets Limited has completed a comprehensive market ... both clinical and research laboratory settings. This study, which ... $6.8 billion and growing to $9.2 billion (CAGR of ... of mass spectrometry across more than 5,200 clinical and ... in the use of mass spectrometry in terms of ...
(Date:1/24/2017)... 2017 Global Market for Pharmaceutical ... A majority of medicines & drugs produced in ... (API), and such processes require alcoholic solvents such as ... of pharmaceutical solvents continues to be concentrated in the ... (APEJ) region as leading API suppliers and ...
Breaking Medicine Technology: