Navigation Links
UCLA-led team may have found key to cause of Cushing disease
Date:5/31/2013

FINDINGS:

Cushing disease is a life-threatening disorder most commonly triggered by tumors, often benign, in the pituitary glands, resulting in excess production of adrenocorticotrophic hormone (ACTH). The condition is marked by progressive weight gain, excessive fatty tissue deposits and a rounding of facial features, known as "moon face," and can lead to diabetes, hypertension, osteoporosis, obesity and psychological disturbances.

Cushing disease, which is more common in women than men, is also associated with a three- to four-fold increase in the risk of premature death. But what drives the tumor growth and the excess production of ACTH?

UCLA researchers and their colleagues have now found that testicular orphan nuclear receptor 4 (TR4) is overexpressed in the tumors. The scientists discovered that by knocking down TR4 in lab mice, they were able to reverse tumor growth and excess ACTH production.

IMPACT:

The findings could potentially lead to a drug therapy for Cushing disease.

AUTHORS:

Study authors included Li Du, Marvin Bergsneider, Leili Mirsadraei, Steven H. Young, William H. Yong and Anthony P. Heaney of UCLA; Johan W. Jonker of the University of Groningen in the Netherlands; and Michael Downes and Ronald M. Evans of Gene Expression Laboratory at the Salk Insitute of Biological Studies in La Jolla, Calif.

JOURNAL:

The findings were published in the May 21 issue of the journal Proceedings of the National Academy of Sciences.

FUNDING:

The research was supported by the National Institutes of Health (grants DK057978, HL105278, DK090962, HL088093, ES010337 and CA014195), the Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, UCLA's Jonsson C
'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA-led project aimed at African American couples affected by HIV gets $2.5 million boost
2. Charity Navigator Awards the Mesothelioma Applied Research Foundation with 4-Star Rating
3. Wheelock Honors Haiti Fund Co-Founder Karen Keating Ansara, Global Fund For Women, And The Singapore Government For International Achievements
4. Kessler Foundations Elaine Katz presents at national summit on disability employment
5. OKeeffe Foundation donates $250,000 to fund Scripps Florida neuroscience training program
6. BioPlus Specialty Pharmacy Founder and CEO Selected as Finalist in Ernst & Young Florida Entrepreneur of the Year Award
7. OsteoVantage™ Receives Supplemental Grant from the National Science Foundation
8. Queens University receives Bill and Melinda Gates Foundation grants
9. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Guided Weight Loss Tips Now Found in New Study to Help Patients Lose Weight Fast
10. The International Essential Tremor Foundation Honored as 2013 Top-Rated Nonprofit
11. Joe Jones, Personal Trainer to Seva Call Founder Shares Tips on Overcoming Gym Intimidation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Utilizing the ... own, Dr. William Koenig, has topped a record number ... he has performed over 400 successful procedures without the ... Koenig is well known across the country for his ... safety record has long been the foundation for numerous ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Ticket Down ... at the Concord Pavilion . When it comes to the ... Luke Bryan. The 37-year-old Georgia native is one of the biggest ... the entertainment business. Bryan is currently out on his “That’s My ... the many stops the tour will be making through the rest ...
(Date:7/11/2014)... 2014 Biostimulants are widely applied in ... and ornamentals. These also help turf and ornamentals in ... roots. Turf, ornamentals, and flowers appear healthy and strong ... has increased from the last few years. The most ... is Europe, with around 40% share in 2013, and ...
(Date:7/11/2014)... PULLMAN, Wash.The largest study of its kind has ... suite of advantages over their conventional counterparts, including ... , The study looked at an unprecedented 343 ... of organic and conventional plant-based foods, including fruits, ... meta-analysis techniques to quantify differences between organic and ...
(Date:7/11/2014)... Down is a reliable source for cheap Luke Bryan tickets ... years Luke Bryan has been honored by almost every major association ... award shows, but each summer, he hits the road on what ... and this summer is more of the same. When it comes ... success that is currently entitled to Luke Bryan. The native of ...
Breaking Medicine News(10 mins):Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 2Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 3
... Eastern Mediterranean Meeting (EMM), which was held in Antalya (TR) ... be organised on 23 and 24 January 2009 in the ... eastern Mediterranean area are expected to participate. , Professor ... I have learnt from the previous EMM meeting is that ...
... WASHINGTON, Jan. 5 Leventhal Consulting, www.leventhalconsulting.net ... lawyers to lose weight, opened today in Washington, ... approach, and works with clients over the phone, ... office.The approach of Leventhal Consulting consists of four ...
... efforts to,educate, inform, and empower the people of Chicago, ... its 25-minute live call-in,show, "Community Health," on Chicago ... PM on Channel 21. , ... Arthur Dorf,Eye Physician and Surgeon on how to choose ...
... Inc., a leader in health care,quality management solutions ... new contract with Summa Health Network (SHN), the,physician-hospital ... largest,organized delivery healthcare systems in Ohio. SHN is ... insurers and one regional insurer,all of which have ...
... 5 Horizon Gynecology & Obstetric,Associates -- a ... & Obstetrics and Gynecology & Obstetrics of,DeKalb -- ... and Sage,Intergy EHR electronic health records system to ... and streamline workflow. , ...
... Mass. and SOUTH SAN FRANCISCO, Calif., Jan. 5 ... venture capital firm, announced today the hiring of Edward ... M.D., Ph.D., as a Principal in the Firm,s Cambridge, ... rooted in their deep understanding of science and technology," ...
Cached Medicine News:Health News:EAU 2nd Eastern Mediterranean Meeting expected to highlight cystectomy 2Health News:Leventhal Consulting Opens for Business 2Health News:For Your Eyes Only - How to Choose and Use Your Eye Doctor 2Health News:Summa Health Network Announces Contract with MDdatacor to Support Multi-Insurer Health Care Quality Initiative; Initiative to Use Clinical Data to Supplement Claims Data and Enhance Outcomes 2Health News:Summa Health Network Announces Contract with MDdatacor to Support Multi-Insurer Health Care Quality Initiative; Initiative to Use Clinical Data to Supplement Claims Data and Enhance Outcomes 3Health News:Horizon Gynecology & Obstetric Associates Chooses Sage Intergy EHR 2Health News:Horizon Gynecology & Obstetric Associates Chooses Sage Intergy EHR 3Health News:Clarus Ventures Hires Former Merck President Ed Scolnick and Broad Institute Scientist Finny Kuruvilla 2Health News:Clarus Ventures Hires Former Merck President Ed Scolnick and Broad Institute Scientist Finny Kuruvilla 3
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
(Date:1/15/2014)... N.J. , Jan. 15, 2014  Celsion Corporation (the "Company") ... has received commitments from institutional investors to purchase an ... stock in an at-the-market registered direct offering, led by ... entered into definitive purchase agreements with these investors pursuant ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: