Navigation Links
UCLA-led team may have found key to cause of Cushing disease
Date:5/31/2013

FINDINGS:

Cushing disease is a life-threatening disorder most commonly triggered by tumors, often benign, in the pituitary glands, resulting in excess production of adrenocorticotrophic hormone (ACTH). The condition is marked by progressive weight gain, excessive fatty tissue deposits and a rounding of facial features, known as "moon face," and can lead to diabetes, hypertension, osteoporosis, obesity and psychological disturbances.

Cushing disease, which is more common in women than men, is also associated with a three- to four-fold increase in the risk of premature death. But what drives the tumor growth and the excess production of ACTH?

UCLA researchers and their colleagues have now found that testicular orphan nuclear receptor 4 (TR4) is overexpressed in the tumors. The scientists discovered that by knocking down TR4 in lab mice, they were able to reverse tumor growth and excess ACTH production.

IMPACT:

The findings could potentially lead to a drug therapy for Cushing disease.

AUTHORS:

Study authors included Li Du, Marvin Bergsneider, Leili Mirsadraei, Steven H. Young, William H. Yong and Anthony P. Heaney of UCLA; Johan W. Jonker of the University of Groningen in the Netherlands; and Michael Downes and Ronald M. Evans of Gene Expression Laboratory at the Salk Insitute of Biological Studies in La Jolla, Calif.

JOURNAL:

The findings were published in the May 21 issue of the journal Proceedings of the National Academy of Sciences.

FUNDING:

The research was supported by the National Institutes of Health (grants DK057978, HL105278, DK090962, HL088093, ES010337 and CA014195), the Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, UCLA's Jonsson Comprehensive Cancer Center, Ipsen/Biomeasure, the Human Frontier Science Program (grant CDA00013/2011-C), and the Netherlands Organization for Scientific Research (VIDI grant 016.126.338).


'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences
Source:Eurekalert

Related medicine news :

1. UCLA-led project aimed at African American couples affected by HIV gets $2.5 million boost
2. Charity Navigator Awards the Mesothelioma Applied Research Foundation with 4-Star Rating
3. Wheelock Honors Haiti Fund Co-Founder Karen Keating Ansara, Global Fund For Women, And The Singapore Government For International Achievements
4. Kessler Foundations Elaine Katz presents at national summit on disability employment
5. OKeeffe Foundation donates $250,000 to fund Scripps Florida neuroscience training program
6. BioPlus Specialty Pharmacy Founder and CEO Selected as Finalist in Ernst & Young Florida Entrepreneur of the Year Award
7. OsteoVantage™ Receives Supplemental Grant from the National Science Foundation
8. Queens University receives Bill and Melinda Gates Foundation grants
9. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Guided Weight Loss Tips Now Found in New Study to Help Patients Lose Weight Fast
10. The International Essential Tremor Foundation Honored as 2013 Top-Rated Nonprofit
11. Joe Jones, Personal Trainer to Seva Call Founder Shares Tips on Overcoming Gym Intimidation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... 2017 , ... The Topricin Companies, formerly Topical Biomedics, is ... natural, after-burn skin care product, Topricin After Burn Cream. , Overexposure ... conditions, including cancer. In the short term, overexposure to sun, wind and ...
(Date:7/24/2017)... Beach, California (PRWEB) , ... July 24, 2017 ... ... commercialization of autologous fat (adipose) transfer systems announces the issuance of United States ... ‘324 patent) for its adipose filtration technology. The '398 and '324 patents ...
(Date:7/24/2017)... ... July 24, 2017 , ... Sharon Kleyne, host of the ... Health on VoiceAmerica sponsored by Nature’s Tears® EyeMist® recently talked on the air about ... in China. , The article by Zidor Aldama described the situation in which Chinese ...
(Date:7/24/2017)... ... July 24, 2017 , ... A Southern California-based author has released a ... and how she has overcome them. “Forbidden Memories: A Memoir,” by author Michelle V. ... she has risen above. , In “Memories,” readers get a firsthand look at what ...
(Date:7/24/2017)... Huntingdon Valley, PA (PRWEB) , ... July 24, 2017 , ... ... wind and rain storms wreak havoc across communities and often result in massive tree ... Top 3 actions homeowners can take now including tree trimming, tree cabling and hazardous ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... -- New York City-based market research firm Kalorama Information notes seven ... From new products to new costs, to the threat of ... study, Potential Pipeline Disruptors . Among them ... 1.  Age-Driven Growth - True Impact Moment Arriving   ... the growing population and, to a more extreme extent, the ...
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
(Date:7/11/2017)... 11, 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... company focused on the development of oral drug delivery ... Administration (FDA) has agreed to schedule an End-of-Phase II ... trial of its oral insulin capsule ORMD-0801 in the ... met primary and secondary endpoints by indicating a statistically ...
Breaking Medicine Technology: