Navigation Links
UCLA launches first face transplantation program in western US
Date:5/25/2012

The UCLA Health System has launched the UCLA Face Transplantation Program, the first surgical program of its kind in the western United States and one of only a handful in the nation.

"Facial transplantation offers the potential to restore humanity to persons who have suffered the devastating loss of their face," said Dr. Kodi Azari, chief of reconstructive transplantation and associate professor of surgery at the David Geffen School of Medicine at UCLA. "People with massive facial injuries often have trouble breathing, speaking and eating, as well as depression and social isolation. Early surgeries have demonstrated very promising results in improving both appearance and function."

The UCLA face transplantation team recognizes the sensitivity required when it comes to working with patients who have experienced a severe facial disfigurement. Understanding that a person's identity and sense of self are closely tied to their facial appearance, the team will also support the patient's emotional adjustment to their new face after the surgery.

"Our goal in creating this program is to return a sense of normalcy to our patients' lives," said Dr. Reza Jarrahy, surgical co-director of the new program and assistant professor of plastic and reconstructive surgery at the Geffen School of Medicine. "We hope that restoring facial form and function will provide the opportunity for patients to lead productive lives that are not defined or hampered by facial appearance."

UCLA is currently seeking patients willing to participate in a face-transplant clinical trial and to be followed for five years after their surgery.

Candidates for the clinical trial will undergo a thorough evaluation to determine whether they meet the criteria for participation. The evaluation includes a comprehensive medical history, a physical examination, lab tests, X-rays and a psychological exam. Approved participants will be placed on a waiting list until the center identifies a suitable match from a donor. Recipients must match the donor's blood type, gender, ethnicity, skin tone, hair pattern and other criteria.

Additional eligibility criteria for the clinical trial include:

  • The patient's facial disfigurement cannot be repaired by conventional surgery.
  • The disfigurement is not due to a birth defect.
  • The patient's age is between 18 and 60 years.
  • The patient has no serious infections, including HIV or hepatitis B or C.
  • The patient is in otherwise good general health.
  • The patient must commit to extensive rehabilitation after surgery, including soft-tissue massage and speech, swallowing and facial-movement therapies.
  • The patient must agree to follow a drug schedule to prevent transplant rejection and attend all appointments at the transplant center.

Dr. Gerald Lipshutz, medical director of the new face transplantation program and associate professor of surgery and medicine at the Geffen School of Medicine, noted that face transplantation is still considered experimental and is not without risk.

"Each patient will need to take drugs the rest of their life to suppress their immune system and prevent rejection of their new face," Lipshutz said. "One of our study's purposes is to look at the effectiveness and safety of the anti-rejection drugs that will be used."

To date, 19 patients worldwide have received partial or complete facial transplants; five of these surgeries have been performed in the United States.

The surgery takes from eight to 20 hours to complete. Surgeons first remove the damaged portions of the patient's face and then attach the donated face to the patient's supporting structures. This includes joining soft tissue like skin, fat, muscles, tendons and ligaments and securing the bones with screws and other hardware. The surgery's most delicate facet involves painstakingly stitching the patient's nerves and blood vessels too small to be seen by the naked eye to those in the new face.

While solid-organ transplants are common at UCLA and other major medical centers, reconstructive transplantation a complex surgery involving a variety of tissues (including bones, tendons, arteries and nerves) marks a new direction for the field. Unlike organ transplants, which are performed to save lives, reconstructive transplants aim to dramatically improve them.

"Microvascular transfer of tissues to reconstruct the face is not new. It is very similar to reconstructive surgery after traumatic injury," said Dr. Ronald W. Busuttil, distinguished professor and executive chairman of surgery at the Geffen School of Medicine, who established the UCLA Liver Transplant Program in 1984, the first on the West Coast. "What makes this study experimental is that we are uniting the fields of microvascular reconstructive surgery and transplantation medicine to transplant the face."

The demand for face transplantation procedures is expected to increase due to long-term U.S. military action overseas. Experts estimate that some 200 veterans have lost all or part of their face. In the civilian sector, nearly 1,000 trauma and burn patients suffer extensive facial injuries that drastically affect their lives.

The UCLA Face Transplantation Program plans to partner with UCLA's highly successful Operation Mend, which offers facial and hand reconstructive surgery to the nation's wounded soldiers.

The program will integrate specialists from throughout the UCLA Health System, including the areas of head and neck surgery, plastic and reconstructive surgery, oral surgery, psychiatry, pathology, anesthesia, internal medicine, radiology, neurology, ethics, and rehabilitation services.


'/>"/>
Contact: Roxanne Moster
rmoster@mednet.ucla.edu
310-794-0777
University of California - Los Angeles Health Sciences
Source:Eurekalert

Related medicine news :

1. Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC
2. Mayo Clinic launches whole genome breast cancer study
3. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
4. Cell Press launches Enhanced Career Network
5. CDC Launches Graphic Anti-Smoking Campaign
6. Life-saving radio campaign launches in Burkina Faso
7. Springer launches 6 new medical review journals
8. Fogarty Institute for Innovation launches advanced endovascular training fellowship
9. Independent medical device review site Which Medical Device launches new Anaesthetics section
10. NIH launches trials to evaluate CPR and drugs after sudden cardiac arrest
11. Mutated Kras spins a molecular loop that launches pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... Ohio (PRWEB) , ... December 09, 2016 , ... ... of miniature, folded, pharmaceutical inserts and outserts. As a means of expanding ... This addition will enable Flottman to individually code professional inserts (PIs) and patient ...
(Date:12/9/2016)... ... , ... Mediaplanet today announces distribution of the latest edition of “Transplants,” a ... as an organ donor for the 123,000 people in the United States who are ... up to 8 saves through organ donation and enhance many others through tissue donation, ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West ... January 1, 2017. The name change aligns the entire company with its ... health care quality. , “We are very proud of the achievements associated with ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... a Property owned by an affiliate of Seavest, has won a prestigious national ... Southern Chester County ambulatory care center (ACC) was named “Best New Development, MOBs ...
(Date:12/8/2016)... ... 2016 , ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing ... wellness program, at their world headquarters of Omni La Costa Resort & Spa in ... anyone seeking weight loss, personal development, a healthy lifestyle, or mental and physical healing. ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... -- RxWiki Inc., a digital health company that powers the ... of pharmacies through its Digital Pharmacist SaaS platform, today ... on Fire" Award in the Health and Life Sciences ... award as one of Austin,s fastest growing companies," said ... "Our platform gives independent retail pharmacies the digital tools ...
(Date:12/9/2016)... Bermuda , Dec. 9, 2016  Axovant ... leading clinical-stage biopharmaceutical company focused on the treatment ... the data from a Phase 2b trial evaluating ... care donepezil, compared with donepezil plus placebo in ... that the addition of intepirdine to treatment was ...
(Date:12/8/2016)... Australia Ophthalmic Lasers Market Outlook to 2022 Summary ... to 2022", provides key market data on the Australia ... of US dollars, volume (in units) and average prices ... and YAG Lasers. The report also provides company ... market segements, and global corporate-level profiles of the key ...
Breaking Medicine Technology: