Navigation Links
UCLA gets $7 million to study substance use and HIV among minority men who have sex with men

The National Institute on Drug Abuse has awarded UCLA a $7 million grant to investigate the links between substance abuse and HIV among Latino and African-American men who have sex with men.

Researchers will examine how non-injected drugs and alcohol can directly interact with the virus and other infectious diseases, to damage these men's health. Enrollment in the study begins in January.

Called MASCULINE (MSM and Substances Cohort at UCLA Linking Infections Noting Effects), the study will be led by Pamina Gorbach, a professor of epidemiology at UCLA's Fielding School of Public Health and a professor of infectious diseases at the David Geffen School of Medicine at UCLA, and Steven Shoptaw, a professor of family medicine at the Geffen School and director of the UCLA Center for Behavioral and Addiction Medicine.

For the study, researchers will establish and maintain an extensive repository of tissue, blood and fluid samples. This repository will be headed by Dr. Peter Anton, a professor of digestive diseases at the Geffen School. Anton, Gorbach and Shoptaw are also members of the UCLA AIDS Institute.

"Alcohol, non-injection use of cocaine and methamphetamine are linked to HIV sexual risk behaviors and transmission of infectious disease," Gorbach said. "But little is known about how these substances can affect biology to produce health threats among those living with or at risk for HIV especially among minority men who have sex with men."

MASCULINE will be a companion study to the Multisite AIDS Cohort Study, the first and largest study specifically created to examine the natural history of AIDS. It will be conducted through the Fielding School's Behavioral Epidemiology Research Group.

A team of clinical researchers, epidemiologists and basic scientists will collaborate to examine the direct effects of drug use on HIV acquisition and treatment, with the primary aim of determining whether and how the use of stimulants and other substances impacts the transmission of HIV and other infections among minority males who have sex with men whose HIV is poorly controlled or who are at high risk of being infected with the virus.

The study will involve a cohort of young substance users particularly users of stimulants who have poor histories of adhering to antiretroviral treatment, allowing researchers to test the biological influences of substances on immune function.

Findings from this unique cohort will shed light on the effects of substance use on the behaviors and clinical outcomes of both HIV-positive and high-risk, HIV-negative minority men that can ultimately be used to improve access to HIV prevention, treatment and care.

The epidemic of HIV among minority men who have sex with men in Los Angeles County, as well as in the U.S. as a whole, may be driven by the effects of drug use on individuals' adherence to their treatment regimens and on biobehavioral prevention, and it may be enhanced by network effects, the researchers said.

"This cohort is central to prevention and treatment efforts and will provide well-characterized, extensive repository samples for leveraged use with other cohorts, networks and individual's studies," Shoptaw said. "This unique cohort will facilitate studies on interactions between substance use and HIV progression and transmission, which are of critical public health significance."

The L.A. Gay and Lesbian Center will be one of the community sites for recruitment of HIV-positive participants for the study; the UCLA Vine Street Clinic will recruit HIV-negative participants.

The MASCULINE study is supported by the National Institute on Drug Abuse of the National Institutes of Health (U01DA036267).


Contact: Enrique Rivero
University of California - Los Angeles Health Sciences

Related medicine news :

1. Servo Motor & Drives Market (AC Servo Motors/Drives, DC Servo Motors/Drives) worth 17.2 Million Units by 2018 - New Report by MarketsandMarkets
2. Network Analytics Market By (Cloud, Mobile & Voip) to Reach $1672.5 Million by 2018 – New Report by Marketsandmarkets
3. Home Automation & Control Systems Market is Expected to Reach $35,627.83 Million by 2016 - New Report by MarketsandMarkets
4. New Designs Of Solid Wood Caskets Just Announced By
5. Succinic Acid Market is Expected to Reach USD 836.2 Million by 2018: Transparency Market Research
6. Smart Solar Market by (Components, Solutions & Regions) Worth $15.34 Million by 2018 – New Report by Marketsandmarkets
7. $5.9 million grant adds androgen receptor as a new driver and target in breast cancer
8. Dartmouth researchers receive $5.9 million grant from NIH for lung research
9. Global Home Automation and Control Systems Market Is Expected to Reach $35,627.83 Million by 2016 – New Reports by MarketsandMarkets
10. Seed Treatment Market (Fungicide, Insecticide, Bio-Control) worth $4,190.4 Million by 2018 - New Report by MarketsandMarkets
11. Nearly $4 million awarded to GW School of Public Health and Health Services researchers
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices in ... that delves into an array of issues that are presently affecting Americans. Dedicated to ... dialogue, this show is changing the subjects consumers focus on, one episode at a ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men ... prominent nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown ... helped advance the healthcare industry as a whole through their advocacy and professional ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... workshops to discuss bioavailability and the need to integrate dose form selection in ... collaboration with OBN, the membership organization supporting and bringing together the UK’s emerging ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... -- --> --> ... potential to save costs, improve treatment quality and accelerate ... exploited as yet. Here, particular emphasis is placed on ... tablet or directly at the patients, bedside. ... -->      (Photo: ) ...
(Date:11/27/2015)... -- Research and Markets ( ) has announced ... 2015-2019" report to their offering. ... the author the present scenario and growth prospects of ... the market size, the report considers revenue generated from ... and copper IUDs. The report forecasts the global intrauterine ...
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
Breaking Medicine Technology: