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UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
Date:9/23/2010

cks the production of effective antibody-producing cells, the plasma cells.

Mara Sherman, the first author of the study who worked as a graduate student in Teitell's lab, said the paper "reflects an exciting and emerging connection between DNA damage response pathways and cell differentiation."

"Our work points to this DNA damage-response pathway as a potential, novel therapeutic target for the treatment of B-cell lymphoma," Sherman said. "Combined with several intriguing recent studies, our work further suggests that pathways with established roles in genome maintenance may also drive the differentiation of stem and progenitor cell populations."

Patients at risk for developing B-cell related cancers could be screened for genes that, when not turned off, are a signature indicating pathway defects. The pathway also could be playing a role in the development of lung, colon and other major cancer types, Teitell said.

Going forward, Teitell and his team will further study the pathway to detail all aspects of its operation so new therapies can be developed to fix it when something goes wrong.


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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California -- Los Angeles
Source:Eurekalert

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