Navigation Links
UCI stem cell researchers to receive $9.35 million in state funding
Date:10/22/2010

Irvine, Calif., Oct. 21, 2010 UC Irvine scientists will receive grants totaling $9.35 million to help create stem cell treatments for retinitis pigmentosa, Huntington's disease and traumatic brain injury.

The grants from the California Institute for Regenerative Medicine were awarded Thursday, Oct. 21, to Dr. Henry Klassen, Leslie M. Thompson, Brian Cummings and Aileen Anderson all members of the Sue and Bill Gross Stem Cell Research Center at UCI to support early-stage translational research.

CIRM's governing board gave 19 such grants worth $67 million to 12 institutions statewide. The research funded by these awards is considered critical to CIRM's mission of translating basic discoveries into clinical cures. The selected projects are expected to either result in candidate drugs or cell therapies or make significant strides toward such treatments, which can then be developed for submission to the Food & Drug Administration for clinical trial.

These grants bring total CIRM funding for UCI to $71.85 million.

"I am delighted that CIRM has made these awards to my colleagues. It speaks to the breadth of outstanding stem cell research at UC Irvine," said Peter Donovan, director of the Sue and Bill Gross Stem Cell Research Center. "The studies they will carry out on eye diseases, Huntington's and traumatic brain injury could have wider implications for the use of stem cells to treat a variety of human diseases, disorders and injuries and could have a major impact."

With a $3.85 million grant, Klassen, assistant professor of ophthalmology, will target a stem cell treatment for retinitis pigmentosa, an inherited form of blindness in which the light-detecting cells in the retina are destroyed. To counteract this, Klassen plans to standardize a method to create photoreceptor progenitor stem cells from immature retinas and then transplant these cells into the eye to repair or replace damaged light-sensing cells. The CIRM grant reviewers gave Klassen's proposal the highest scientific score 93 on a scale of 100 among all applicants for early translational grants. "The eye is an important proving ground for stem cell-based therapies and provides a stepping stone to many otherwise incurable diseases of the brain and spinal cord," he said.

With a $3.8 million grant, Thompson, professor of psychiatry & human behavior and neurobiology & behavior, will develop a technique using stem cells to support areas of the brain susceptible to Huntington's disease, an inherited, incurable and fatal neurodegenerative disorder. "These cells offer a possible long-term treatment approach that could relieve the tremendous suffering experienced by patients and their families," she said.

In 2008, Thompson received a $1.4 million CIRM grant to create human embryonic and adult-derived stem cell lines from individuals carrying the Huntington's genetic mutation in order to study the disease.

With a $1.7 million grant, Cummings and Anderson, both associate professors of physical medicine & rehabilitation and anatomy & neurobiology, will explore utilizing neural stem cells to treat traumatic brain injury, which devastates 1.4 million Americans each year. The researchers believe these cells, when introduced into the injury site, will grow into new neurons, replacing damaged and dead ones, and facilitate recovery. They plan to develop a number of stem cell lines for addressing traumatic brain injury. "If successful, these lines would be potentially useful for treating a variety of other central nervous system disorders, including Alzheimer's, Parkinson's, stroke, spinal cord injury and multiple sclerosis," Cummings said.

Earlier this year, he, Anderson and UCI neurobiology researcher Hal Nguyen were awarded a CIRM basic biology grant of $1.3 million to study the properties of induced pluripotent stem cells to learn whether these cells could treat central nervous system injury and disease.

The four researchers' work will take place in Sue and Bill Gross Hall: A CIRM Institute, an $80 million, 100,000-square-foot structure that opened on campus in May, becoming the first major stem cell facility in Southern California.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California -- Irvine
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... – , ... May ... a manufacturer of innovative infant and child products, today revealed the ... their ability to help babies deal with teething pain is just ... contain no toxic gels, and are BPA-, PVC-, and phthalate-free. ...
(Date:5/4/2016)... ... 04, 2016 , ... Over 40 athletic trainer’s (ATs) and athletic training students ... annual “Hike to Harrisburg” advocacy day. The annual lobbying effort is a collaboration ... The goal for the day was to educate the elected legislators and the ...
(Date:5/4/2016)... Connecticut (PRWEB) , ... May 04, 2016 , ... Netc , a leading provider ... Labels from Art Style Printing, Inc. The Dataware acquisition enables Netc to continue to grow ... with Netc Blank Label Stock provides customers with the ability to print and label tape ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ProIntro Glitch ... Cut Pro X. Pixel Film Studios’ titles allow users to add a terrifying opener ... elements such as boxes, lines and accents. To add greater contrast, all the user ...
(Date:5/3/2016)... , ... May 03, 2016 , ... Sue Desmond-Hellmann, chief ... of 2016 to stretch the limits of human possibility in her keynote address at ... in the Georgia Dome. , Drawing on her rich experience as a scientist, physician ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... LLC (Forté) is excited to announce the launch of its Mediceutical line of products, ... for a variety of clinical conditions. Founded in 2013, Forté spent more than two ... Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
(Date:5/2/2016)... Leading Economies with Fastest Real GDP Annual Percentage Change, 2015  ... 7.8 India 7.3, , Source: IMF and TechSci Research   ... Brazil , Russia , India ... , registered the fastest GDP growth during the first decade of the 21 ... in Brazil and Russia , along ...
(Date:5/2/2016)... 2, 2016 The global  ... 11.1 billion by 2024, according to a new ... drivers of the sonography market include expanding applications ... recommendations for periodic ultrasound screenings of the breast ... http://photos.prnewswire.com/prnh/20150105/723757 ) High Intensity Focused ...
Breaking Medicine Technology: