Navigation Links
UCI researchers find new way to fight cocaine addiction
Date:4/1/2009

Irvine, Calif., April 1, 2009 UC Irvine pharmacological researchers have discovered that blocking a hormone related to hunger regulation can limit cocaine cravings. Their findings could herald a new approach to overcoming addiction.

Led by Shinjae Chung and Olivier Civelli, the study identified how the melanin-concentrating hormone works with dopamine in the brain's "pleasure center" to create an addictive response to cocaine use. The researchers further found that blocking MCH in these brain cells limited cocaine cravings.

Dopamine is a neurotransmitter essential to the normal functioning of the central nervous system. It also is associated with feelings of pleasure and is released in the brain during eating, sex and drug use. Heightened levels of the neurotransmitter have been detected in the nucleus accumbens of drug addicts.

The study is the first to detail the interaction of MCH and dopamine in cocaine addiction and show that it occurs in the nucleus accumbens, a portion of the forebrain believed to play an important role in addiction and feelings of pleasure and fear. Study results appear in this week's early online edition of the Proceedings of the National Academy of Sciences.

"This discovery indicates that MCH is a key regulator of dopamine in a brain area associated with both pleasure and addiction," says Civelli, the Eric L. and Lila D. Nelson Professor of Neuropharmacology. "We believe that efforts to target MCH may lead to new treatments to break addiction to cocaine and, possibly, other drugs, like amphetamines and nicotine."

In mammals, MCH is involved with the regulation of feeding behavior and energy balance. High levels of the hormone can intensify feelings of hunger, and researchers worldwide have been seeking compounds to lower MCH for potential use in the treatment of obesity.

Chung and Civelli believe MCH works in the nucleus accumbens to increase the pleasure of eating. They
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers question effectiveness of warning labels on over-the-counter drugs
2. Researchers Successfully Create Computer-Simulated Model for Evaluating Artificial Pancreas
3. Yale researchers discover mechanism for
4. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
5. Researchers decipher blood stem cell attachment, communication
6. Researchers studying hearing loss find auditory regions of the brain convert to the sense of touch
7. UIC researchers measure health effects of Chicagos waterways
8. Focus on treating malnutrition in cancer patients, researchers say
9. Researchers Suspect Genetic Link to COPD
10. Syracuse University researchers build a new surface material that resists biofilm growth
11. Researchers Use Gene to End High Blood Sugar in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014 (HealthDay News) -- Social networking sites can help ... For people who are obese, sites like Twitter and ... support from doctors as well as peers, researchers found. ... methods is that it offers the potential to be ... when compared to traditional approaches," the study,s lead author, ...
(Date:9/17/2014)... September 17, 2014 The Oliver Law ... infections allegedly caused by Non-Sterile Other-Sonic Ultrasound Transmission ... about their options for legal recourse. Other-Sonic ultrasound gel ... (FDA) in March 2012, after the product was linked ... William Beaumont Hospital in Royal Oak, Michigan . While ...
(Date:9/17/2014)... 2014 Catalent Pharma Solutions, the ... development solutions for drugs, biologics and consumer health ... integrated service and technology offer based on the ... the company’s 450,000 sq. ft. Kansas City, MO ... integrate optimal formulation, development, analytical expertise, scale up ...
(Date:9/17/2014)... -- A blood test that measures DNA from a ... assessment of the state of a man,s disease, a ... blood test could reveal when treatment for advanced ... growth, the researchers suggested. "Our study showed that ... cancer and often initially very effective started to activate ...
(Date:9/17/2014)... R.I. [Brown University] As Congress adjourns this month ... senators will step over on their way out the ... Repeal and Medicare Provider Payment Modernization Act of 2014. ... Surgery , Dr. Eli Adashi recounts what he and ... bipartisan bill. The perennial trouble with how Medicare pays ...
Breaking Medicine News(10 mins):Health News:Social Networking Sites Can Help Obese Lose Weight: Study 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 3Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 4Health News:New OptiPact™ Technology Introduced by Catalent 2Health News:DNA Blood Test Might Identify Status of Prostate Cancer 2Health News:Failed Medicare payments law remains relevant 2Health News:Failed Medicare payments law remains relevant 3
... ... Enter Three Year GPO Agreement , ... Wichita, KS (PRWEB) October 26, 2009 -- MedAppz, a leading provider ... Chain Systems, today announced a multiyear agreement to offer EHR software as a service ...
... Disproportionate impact ... is ticking for tens of thousands of heart patients in rural America as a looming ... cardiac care. , ... MI (PRWEB) October 26, 2009 -- The clock is ticking for tens of thousands of ...
... 26, 2009 A discovery by scientists at the Oklahoma ... injuries like those sustained in car crashes or on the ... diseases and diabetes. In a paper published online today ... Medicine , OMRF researcher Charles Esmon, Ph.D., with co-authors Florea ...
... are of particular note in today,s Scientific Program ... of Ophthalmology (AAO) and the Pan-American Association of Ophthalmology ... exam clues that should make ophthalmologists suspect an atypical ... Singapore National Eye Center study that diabetics who are ...
... suggests they,re more susceptible to dangers of tobacco , SUNDAY, ... than men to the carcinogens and other noxious substances in ... one study of nearly 700 people with lung cancer, Swiss ... received the diagnosis, even though they smoked less than the ...
... Oct. 24, 2009 Born with a retinal disease that ... sightless, the nine-year-old boy used to sit in the back ... electronic screen and assisted by teacher aides. Now, after a ... back of his eye, he sits in front with classmates ...
Cached Medicine News:Health News:MedAppz Signs Agreement with MedAssets to Offer SAAS-based Electronic Health Record to MedAssets' Non-acute Customers 2Health News:Cardiac Patients Across Rural America Risk Losing Access to Nearby Care as Federal Agency Considers Cuts this Week 2Health News:Cardiac Patients Across Rural America Risk Losing Access to Nearby Care as Federal Agency Considers Cuts this Week 3Health News:Oklahoma scientists discover promising new path for treating traumas 2Health News:Clues to visual variant Alzheimer's; myopia and diabetic retinopathy risk 2Health News:Clues to visual variant Alzheimer's; myopia and diabetic retinopathy risk 3Health News:Is Smoking Tougher on Women? 2Health News:Is Smoking Tougher on Women? 3Health News:1 shot of gene therapy and children with congenital blindness can now see 2Health News:1 shot of gene therapy and children with congenital blindness can now see 3Health News:1 shot of gene therapy and children with congenital blindness can now see 4Health News:1 shot of gene therapy and children with congenital blindness can now see 5
(Date:9/17/2014)... Brazil Gynecological Devices Market ... GlobalData,s new report, "Brazil Gynecological Devices Market ... the Brazil Gynecological Devices market. The report provides ... units) and average prices (in US dollars) within ... Devices (Micro-inserts) and Mechanical Sterilization Devices (Tubal Clips ...
(Date:9/17/2014)... , Sept. 17, 2014 The ... the last decade due to the recession, ... and technological advancements. This BCC Research report ... segments of the ambulance and emergency medical ... blood and hemorrhage control devices, equipment used ...
(Date:9/17/2014)... MONICA, Calif. , Sept. 17, 2014  Dr. ... is at the White House today for National Recovery ... 46 that consumer advocates released today. Consumer advocates were ... woman who spoke out after losing her fiancée ... discovering that the doctor had a history of crack ...
Breaking Medicine Technology:Brazil Gynecological Devices Market Outlook to 2020 2Brazil Gynecological Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 2Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 3
... 26, 2011 Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX ... overview at the Jefferies 2011 Global Healthcare Conference on June ... The live and archived webcast of the company ... Idenix Investor Center at www.idenix.com . Please log in ...
... A new prostate cancer study published ... treatment to "watchful waiting" revealed important findings for ... debating their treatment options. (Photo:   http://photos.prnewswire.com/prnh/20110526/NY09899 ... clinical options for early prostate cancer treatment today ...
Cached Medicine Technology:Robotic Prostatectomy Expert Dr. David Samadi on a High Impact Study Advocating Aggressive Early-Stage Prostate Cancer Treatment 2Robotic Prostatectomy Expert Dr. David Samadi on a High Impact Study Advocating Aggressive Early-Stage Prostate Cancer Treatment 3
EPS 3501 : 3500 V, 150 mA, 100 W maximum. Constant voltage, constant current, or constant power modes. Stores and recalls three protocols. Excellent for manual DNA sequencing and IEF applications....
... power supply, with temperature probe, 100-120 and 220-240 ... 500 mA, and 400 W. The temperature probe ... and 90 degrees C during electrophoresis. Built-in infrared ... and instructions are provided. Dimensions are 27.5 x ...
... SPECIFICATIONS Form: Granular, free flowing powder EEO(-m r ): ... (3%): less than or equal to 31C Remelt ... Gel Strength (3%): greater than or equal to 500 ... equal to 1000 gm/cm 2 Moisture: less than ...
... chloride (Cl) ≤ 500 mg/kg sulfate (SO 4 ) ... Cd ≤ 5 mg/kg Co ≤ 5 mg/kg Cr ... 10 mg/kg K ≤ 50 mg/kg Mg ≤ 50 ... Ni ≤ 5 mg/kg Pb ≤ 5 mg/kg Zn ...
Medicine Products: