Navigation Links
UCI researchers find cause of chemotherapy resistance in melanoma
Date:9/17/2012

Irvine, Calif., Sept. 17, 2012 Researchers with UC Irvine's Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy.

UCI dermatologist Dr. Anand Ganesan and colleagues found a genetic pathway in melanoma cells that inhibits the cellular mechanism for detecting DNA damage wrought by chemotherapy, thereby building up tolerance to cancer-killing drugs.

Targeting this pathway, comprising the genes RhoJ and Pak1, heralds a new approach to treating the deadly skin cancer, which claims nearly 10,000 U.S. lives each year. Study results appear online in Cancer Research, a journal of the American Association for Cancer Research.

"If we can find a way to turn off the pathway responsible for this resistance, melanoma tumors would suddenly become sensitive to therapies we've been using for the last 20 years," said Ganesan, assistant professor of dermatology and biological chemistry at UCI.

In pursuit of a cause for the chemo tolerance, he and his colleagues performed a genome-wide scan for genes controlling drug resistance in melanoma cells. Their search identified RhoJ, a gene normally involved in blood vessel growth. They saw that in response to drug-induced DNA damage in a melanoma cell, RhoJ activated another gene, Pak1, which initiated a molecular cascade suppressing the cell's ability to sense this damage and blocking the apoptosis process.

"Normally, such drug-induced DNA damage would result in cell death," Ganesan said. "But this blunting of DNA damage response allows melanoma cells to mutate and proliferate. Being capable of rapid adaptation and change is a hallmark feature of this challenging form of cancer and makes it very difficult to treat."

On the heels of this discovery, he and colleagues have begun exploring methods to inhibit the genes responsible for this DNA damage tolerance. What they come up with could one day supplement chemotherapy treatments for melanoma, Ganesan added.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Majority of US Schools not ready for next pandemic, SLU researchers say
2. Researchers call for early diagnosis of flesh-eating infections
3. UMass Amherst sleep researchers study value of preschool naps
4. Moffitt cancer center researchers find novel predictor for MDS progression risk
5. HF/E researchers examine older adults willingness to accept help from robots
6. Local talent: Global impact public invited to meet world-class researchers at Queens
7. Researchers improve gene therapy technique for children with immune disorder
8. Moffitt researchers say race affect likelihood of finding suitable stem cell donor
9. Researchers closer to understanding actions of cells involved in atherosclerosis
10. Case Western Reserve researchers create short-term memories in-vitro
11. Researchers find first evidence for a genetic cause for Barretts esophagus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... City, GA (PRWEB) , ... February 08, 2016 , ... ... and cavity-free. February is National Children’s Dental Health Month and family dentist Yvonne Dorrian, ... 3 p.m. at Coast Dental , located next to Target at 1207 North ...
(Date:2/8/2016)... ... 08, 2016 , ... Brenton Engineering , powered by ... flow wrapped products at WestPack 2015, February 9-11, in Anaheim, California. This new ... semi-automatic or fully-automatic case packing with a small footprint, rugged, highly flexible, and ...
(Date:2/8/2016)... Indianapolis, IN (PRWEB) , ... February 08, 2016 ... ... serving the Indianapolis, IN metro area, has selected the latest beneficiary of their ... nonprofit organization dedicated to preventing bullying in area schools. Donations are now being ...
(Date:2/8/2016)... AUSTIN (PRWEB) , ... February 08, 2016 , ... Remember ... next time. , According to Perry A~, author of “Calcium Bentonite Clay” the ... a key role in balancing and detoxifying the body. , A former motivational speaker, ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... greater than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth ... ”It is time to make a change in public health,” states Carole Baggerly, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016 /PRNewswire/--  Cell Applications, Inc. ... tissue-engineering services are now available in ... three-dimensional (3D) bioprinting approach called the "Kenzan Method." ... , a state-of-the-art robotic system that fabricates 3D ... powerful pay-for-service bio-printing model that makes scaffold-free tissue ...
(Date:2/8/2016)... , Feb. 8, 2016  Avista Pharma Solutions ... Eric Setzer as Chief Financial Officer (CFO). Mr. Setzer ... years of experience in various roles within growing technology ... he served as the Executive Director of Finance at ... Raleigh, NC . Previously, Mr. Setzer ...
(Date:2/8/2016)... -- Velano Vascular, a medical technology company transforming and ... practitioners, announced today that the company has raised an ... proceeds from this financing, an extension of a $5 ... support the development and commercialization of the company,s inpatient ... Philadelphia , and a number of ...
Breaking Medicine Technology: