Navigation Links
UCI researchers create new strategy for highly selective chemotherapy delivery
Date:9/25/2009

Irvine, Calif. UC Irvine researchers have created a new approach that vastly improves the targeting of chemotherapeutic drugs to specific cells and organs.

Kenneth Longmuir, associate professor of physiology & biophysics, and Richard Robertson, professor of anatomy & neurobiology, used liposomes, small spheres (less-than 100 nanometer in diameter) of naturally-occurring lipid molecules, as "packages" for the cancer chemotherapeutic agent doxorubicin, and a small peptide molecule to "address" the package to the targeted tissue.

Using this technology, the research team demonstrated that the doxorubicin was directed almost entirely to the targeted site with virtually no uptake by other organs, including lung, kidney and heart.

Their study appears online in the International Journal of Pharmaceutics.

Their approach is based on the fact that all tissues and organs, including all tumors, are surrounded by a dense region of sugar-containing molecules called polysaccharides. Most importantly, the particular chemical composition of the polysaccharides is different in each tissue and organ of the body. The chemical compositions of the polysaccharides of tumor regions are also different from normal tissue.

The research team developed a nanocarrier system that can recognize specific types of polysaccharide, and has demonstrated effective, organ-specific delivery of nanocarriers, and their therapeutic contents, based upon this polysaccharide-targeting approach.

In their study, the researchers used a peptide derived from a protein found in the microorganism Plasmodium, which is an organism well-known for its exceptional ability to exclusively target the polysaccharides of liver following entry into the bloodstream.

The drug doxorubicin is a chemotherapeutic agent commonly used as treatment for a variety of cancers. Although it is an effective anti-cancer agent, the usefulness of doxorubicin is compro
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCI researchers create new strategy for highly-selective chemotherapy delivery
2. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
3. VA Honors Eye Researchers With Olin Teague Award
4. Researchers find drug-eluting stents safe, effective for PCI in diabetics
5. Researchers Propose Improved Cervical Cancer Screening
6. Researchers Perfect the View of Heart Disease
7. Mayo Clinic researchers lead national trial testing new treatment for chronic, severe indigestion
8. Indiana U medical researchers boost research and jobs with stimulus legislation grants
9. Canadian researchers discover the first-ever link between intelligence and curiosity
10. MUSC Researchers Concerned About Online Drug Availability
11. UCLA researchers develop biomarker for rapid relief of major depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Dr. Tim Novelli, DC., Founder ... mission is to increase acceptance of the chiropractic field in the military. All too ... them. Although Chiropractic was made available to the VA program over a decade ...
(Date:8/29/2015)... ... August 29, 2015 , ... People ... pulmonary disease (including emphysema), or asthma, are at higher risk from wildfire smoke ... attack, heart failure or heart-rhythm problems (arrhythmia or irregular heartbeat) are also sensitive ...
(Date:8/28/2015)... ... August 29, 2015 , ... Rio Salado College ... and the student experience as part of the EDUCAUSE - Next Generation Learning Challenges ... , This is the third Breakthrough Models Incubator hosted by EDUCAUSE and ...
(Date:8/28/2015)... ... 2015 , ... The Kentucky State Department of Workforce Investment Commissioner Beth Kuhn ... applying for, they are unable to pass the initial drug test and therefore unable ... in order to be able to hire long-term, skilled talent. (1) Will Wesch, Director ...
(Date:8/28/2015)... , ... August 28, 2015 ... ... for Medical Devices:, Understanding the FDA’s Position and Best Practices for Compliance, ... http://www.fdanews.com/cybersecuritymd , This workshop, chaired by internationally renowned expert Fubin Wu, ...
Breaking Medicine News(10 mins):Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:Heart Fit Clinic Sounds the Alarm on Forest Fire Smoke and Chronic Heart Disease in Calgary Area 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5
... due to the infection of a hospital superbug at James ... Difficile, commonly known as C diff, within the last four ... the patients were infected with a virulent strain of the ... to be performed on five other patients who had contracted ...
... Support from Northern Ireland has sought for the cancer drugs ... such prescriptions will be free from April 1// and appealed ... ,In Northern Ireland around 9,000 people are diagnosed with cancer ... is highly unfair to charge these patients as it causes ...
... was shortened as Calgaria. But this has failed to soothe ... insult those afflicted by mental sickness. ,“I realize ... those of us living with mental illness who have to ... who suffers from depression and sits on the board for ...
... that stents do not prevent heart attacks as considered. ... and to prevent heart attacks//. Stents are hollow tubes ... ,This landmark study funded by the U.S. ... blood flow but are no more effective in preventing ...
... related to AAWL in adults between the ages of ... ,Arthritis, a leading cause of disability ... limitation (AAWL) can have substantial social and economic impacts ... ,This study was published in the ...
... pituitary gland, a pea-sized gland found at the base of ... say. ,The gland produces a range of hormones ... coping with daily stress, general well being and sex drive. ... in Turkey measured the levels of these hormones in 22 ...
Cached Medicine News:Health News:Stents Do Little to Prevent Heart Attacks 2Health News:AAWL Affects Quality of Life 2Health News:AAWL Affects Quality of Life 3
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... announced the addition of the "Investigation Report on ... Developed by Roche under the trade name ... in the world. In Feb.26, 2010, it was approved ... injections available in China all ...
(Date:8/28/2015)... 2015 Research and Markets ... "Investigation Report on China,s Tobramycin Market, 2010-2019" ... traditional antibiotic whose eye drop and ointment are the ... infection or inflammation caused by eye infection. Currently, dozens ... able to produce tobramycin, among which the Top 5 ...
(Date:8/28/2015)... 28, 2015 Patterson Medical, formerly the ... PDCO ), is now an independent company with ... Patterson Medical by Madison Dearborn Partners (MDP).  ... for a transition period before rebranding as the ... medicine products.  With the focused resources and expertise ...
Breaking Medicine Technology:Investigation Report on China's Bevacizumab Market 2015-2019 2Investigation Report on China's Tobramycin Market, 2015-2019 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3
... 3 Mach 7 Technologies (M7T), a global provider of ... tools to its flagship Keystone Suite Enterprise Image Management Platform.  The ... Study Split Utility (SSU), and the Keystone Study Import - Export ... , ...
... Asymchem Laboratories announces the hiring of Dr. ... June 1, 2010 .  Dr. Zhang is an expert in ... he worked for 10 years for Wyeth at Rouse,s Point, ... Plant Process Engineering.  He has additional experience as an R&D ...
Cached Medicine Technology:Mach 7 Technologies Rolls Out Keystone Study Segmentation, Rapid Migration and Import - Export Utilities 2Mach 7 Technologies Rolls Out Keystone Study Segmentation, Rapid Migration and Import - Export Utilities 3Mach 7 Technologies Rolls Out Keystone Study Segmentation, Rapid Migration and Import - Export Utilities 4
Pefakit in-TDT Calibrators and Controls...
PT-HS with Calcium - 2 ml...
Plasma Control Level 1 - 1 ml...
The ACE Alera clinical chemistry system serves a wide variety of chemistry diagnostic needs with the power of a large floor model analyzer in an easily integrated and economizing compact footprint of...
Medicine Products: