Navigation Links
UCI researchers create mosquitoes incapable of transmitting malaria
Date:6/12/2012

Irvine, Calif., June 12, 2012 Mosquitoes bred to be unable to infect people with the malaria parasite are an attractive approach to helping curb one of the world's most pressing public health issues, according to UC Irvine scientists.

Anthony James and colleagues from UCI and the Pasteur Institute in Paris have produced a model of the Anopheles stephensi mosquito a major source of malaria in India and the Middle East that impairs the development of the malaria parasite. These mosquitoes, in turn, cannot transmit the disease through their bites.

"Our group has made significant advances with the creation of transgenic mosquitoes," said James, a UCI Distinguished Professor of microbiology & molecular genetics and molecular biology & biochemistry. "But this is the first model of a malaria vector with a genetic modification that can potentially exist in wild populations and be transferred through generations without affecting their fitness."

More than 40 percent of the world's population lives in areas where there is a risk of contracting malaria. According to the Centers for Disease Control & Prevention, 300 million to 500 million cases of malaria occur each year, and nearly 1 million people die of the disease annually largely infants, young children and pregnant women, most of them in Africa.

James said one advantage of his group's method is that it can be applied to the dozens of different mosquito types that harbor and transmit the Plasmodium falciparum parasite, including those in Africa. Study results appear this week in the early online version of the Proceedings of the National Academy of Sciences.

The researchers conceived their approach through mouse studies. Mice infected with the human form of malaria create antibodies that kill the parasite. James' team exploited the molecular components of this mouse immune-system response and engineered genes that could produce the same response in mosquitoes. In their model, antibodies are released in genetically modified mosquitoes that render the parasite harmless to others.

"We see a complete deletion of the infectious version of the malaria parasite," said James, a member of the National Academy of Sciences. "This blocking process within the insect that carries malaria can help significantly reduce human sickness and death."

He and his colleagues have pioneered the creation of genetically altered mosquitoes that limit the transmission of dengue fever, malaria and other vector-borne illnesses.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
2. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
3. VCU researchers identify changes in cholesterol metabolic pathways
4. An important breakthrough in immunology by IRCM researchers
5. Mount Sinai researchers develop a multi-target approach to treating tumors
6. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
7. Researchers at IRB Barcelona uncover new clues about the origin of cancer
8. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
9. Student researchers seek to develop new therapies for cancer
10. Researchers call for obesity prevention efforts to focus on community-wide systems
11. Listening in, researchers learn about end-of-life communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, ... three leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has ...
Breaking Medicine Technology: