Navigation Links
UCI researchers create mosquitoes incapable of transmitting malaria
Date:6/12/2012

Irvine, Calif., June 12, 2012 Mosquitoes bred to be unable to infect people with the malaria parasite are an attractive approach to helping curb one of the world's most pressing public health issues, according to UC Irvine scientists.

Anthony James and colleagues from UCI and the Pasteur Institute in Paris have produced a model of the Anopheles stephensi mosquito a major source of malaria in India and the Middle East that impairs the development of the malaria parasite. These mosquitoes, in turn, cannot transmit the disease through their bites.

"Our group has made significant advances with the creation of transgenic mosquitoes," said James, a UCI Distinguished Professor of microbiology & molecular genetics and molecular biology & biochemistry. "But this is the first model of a malaria vector with a genetic modification that can potentially exist in wild populations and be transferred through generations without affecting their fitness."

More than 40 percent of the world's population lives in areas where there is a risk of contracting malaria. According to the Centers for Disease Control & Prevention, 300 million to 500 million cases of malaria occur each year, and nearly 1 million people die of the disease annually largely infants, young children and pregnant women, most of them in Africa.

James said one advantage of his group's method is that it can be applied to the dozens of different mosquito types that harbor and transmit the Plasmodium falciparum parasite, including those in Africa. Study results appear this week in the early online version of the Proceedings of the National Academy of Sciences.

The researchers conceived their approach through mouse studies. Mice infected with the human form of malaria create antibodies that kill the parasite. James' team exploited the molecular components of this mouse immune-system response and engineered genes that could produce the same respons
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
2. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
3. VCU researchers identify changes in cholesterol metabolic pathways
4. An important breakthrough in immunology by IRCM researchers
5. Mount Sinai researchers develop a multi-target approach to treating tumors
6. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
7. Researchers at IRB Barcelona uncover new clues about the origin of cancer
8. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
9. Student researchers seek to develop new therapies for cancer
10. Researchers call for obesity prevention efforts to focus on community-wide systems
11. Listening in, researchers learn about end-of-life communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... A novel compound that targets an important brain receptor ... addiction behaviors, including relapse behavior, a University at Buffalo ... evidence that this may be a novel lead compound ... exist., The UB research was published as an online ... In the study, the compound, RO5263397, severely blunted a ...
(Date:4/23/2014)... April 23, 2014Men whose testosterone falls below normal levels ... be overweight and have heart disease and type 2 ... testosterone-deficient men for further testing and possible treatment is ... Health , a peer-reviewed publication from Mary Ann Liebert, ... Journal of Men,s Health website at ...
(Date:4/23/2014)... and accessible detection methods that can rapidly screen ... a single cell inside that population has been ... Lu. , In the Royal Society of Chemistry ... that he and his coworkers have developed a ... a protein ( Chem. Sci. , 2014, DOI: ...
(Date:4/23/2014)... benefits of probiotics, antioxidants and other nutritional compounds, more ... industry is getting in on the action. But legitimate ... the industry is responding with clinical research to shore ... Chemical & Engineering News (C&EN), the weekly ... M. Bomgardner, a senior editor at C&EN, writes that ...
(Date:4/23/2014)... Ill. - In a country as wealthy as the United ... 12 seniors do not have access to adequate food due ... food insecure. , Recent research at the University of ... Survey (NHANES) revealed that the seniors who are dealing with ... , "In 2011, 8.35 percent of Americans over age 60 ...
Breaking Medicine News(10 mins):Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:More Americans in their golden years are going hungry 2
... be common in tropical countries along with the ... researchers in Houston, Texas whose study was published in ... available online. ,Staphylococcus aureus, or staph, ... in the nose of a quarter to a third ...
... the caregiver to a 12-year-old autistic boy who fell to ... being charged with the boy's// death. This despite the police ... his death. ,The boy's name has never been ... not say if they were reopening the case or what ...
... potent herbs, has now uncorked a new product: herbal wine. ... Thapa, a resident of tourist town Pokhara in western Nepal, ... ,For many families, alcohol is an integral part of ... local liquors thrive in Nepal's markets along with foreign beers, ...
... between overweight and infertility in women is well known, but ... the case of obese men.//, ,New research has ... that a man’s chances of getting infertile are enhanced by ... during the four years prior to participating in the study ...
... develop symptoms like chest pain or breathlessness almost 2 hours ... death victims were already at a risk as they had ... prevent sudden cardiac death can be made by learning to ... ,"Our study suggests that shifting the focus to educating ...
... often than biologists once thought. Cutting and rearrangement of the ... by// the human cells. ,The immune system of ... could also help researchers understand better how the immune system ... ,Depending on the specific type of protein required, an ...
Cached Medicine News:Health News:MRSA Linked with Rise in Bacterial Infections 2Health News:Nepal Uncorks 'Herbal Wine' 2Health News:Symptoms develop long before the 'Sudden' Cardiac Death 2Health News:'Mix and match' of proteins may have a significant role in immunity 2
(Date:1/15/2014)... LAVAL, Quebec , Jan. 15, 2014  Valeant Pharmaceuticals ... VRX) announced that the applicable waiting period under the ... to the previously announced tender offer by its indirect ... the outstanding shares of common stock of Solta Medical, ...
(Date:1/14/2014)... 2014 HeartWare International, Inc . (NASDAQ: ... miniaturized circulatory support technologies that are revolutionizing the treatment ... revenues for the fourth quarter of 2013 will be ... approximately $208 million. "Our full-year revenue growth ...
(Date:1/14/2014)... , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new ... targeting guide with accompanying instrumentation to place and insert ... to the soft tissue (e.g. ligament) repair or reconstruction ... repair heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... Mass.--(BUSINESS WIRE)--Jul 3, 2007 - EPIX,Pharmaceuticals, Inc. (NASDAQ:EPIX) ... executive officer of EPIX, is,scheduled to present at ... Tuesday, July 10, 2007 at 1:30 p.m.,(EDT) at ... The presentation will be webcast live and can ...
... DIEGO--(BUSINESS WIRE)--Jul 2, 2007 - Accelrys, Inc.,(NASDAQ:ACCL), the ... announced today that its CFO,Rick Russo, will present ... in New York on July 11, 2007 at,10:30 ... the Mandarin,Oriental Hotel July 10th-12th. In attendance will ...
Cached Medicine Technology:EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin,Emerging Growth Opportunities Conference 2Accelrys to Present to Investors at C.E. Unterberg Emerging Growth,Opportunities Conference 2
Infusion Cannula, 4.0mm....
Subretinal Injection Cannula, Curved; 20g (0.90) x 1" (25mm); Tip Extension: 3mm, 32g (0.23); Angled at 35°....
Subretinal Fluid Cannula, Straight; 20g (0.90) x 1-1/2" (38mm); 12mm Flexible Tubing Extends 6mm Beyond Tip....
Micro Vitreoretinal Cannula; Angled; 20g (0.90) x 1" (25mm); Tip Extension: 3mm, 32g (0.23); Angled at 65°, 1mm from Tip....
Medicine Products: