Navigation Links
UCI non-small cell lung cancer study highlights advances in targeted drug therapy
Date:11/1/2010

Orange, Calif., Nov 1, 2010 A UC Irvine oncologist's work with a targeted therapy is showing great promise in patients with a deadly form of lung cancer. The results were published Thursday in the New England Journal of Medicine.

The multicenter study is testing whether the drug crizotinib effectively slows, stops or reverses growth in advanced non-small cell lung cancer tumors by targeting a genetic mutation that causes uncontrolled tumor growth. Study participants all tested positive for a mutation in the anaplastic lymphoma kinase gene.

According to the findings, tumors disappeared or shrank in 57 percent of patients. Tumors ceased growing in another 33 percent. The response rate to the current standard of care for advanced non-small cell lung cancer is about 15 percent.

"For the majority of patients, the treatment right now is chemotherapy plus targeted therapy in those eligible," said Dr. Ignatius Ou. "In the future, with the advance of personalized medicine, we hope to be able to identify specific genetic change in the lung cancer and treat patients with specific inhibitors that can improve survival rates and quality of life."

The New England Journal of Medicine article includes data from 82 patients treated in Phase 1 of this study, sponsored by the pharmaceutical company Pfizer. The targeted genetic mutation is particularly prevalent among those who have never smoked. Study participants ranged in age from 25 to 78, with 76 percent of them nonsmokers.

Ou treated 15 patients in UCI's Phase 1 trial, most from Los Angeles, Orange and San Diego counties. One person came from Arizona each month for treatment and assessment. Ou is currently enrolling patients in Phase 2 and 3 trials for crizotinib. Interested candidates should contact the UCI clinical trials office at 714-456-6241.

Each year, about 1.5 million new cases of lung cancer are diagnosed globally. Nearly 75 percent of people wit
'/>"/>

Contact: John Murray
jdmurray@uci.edu
714-456-7759
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
4. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
5. Comparision of overall survival for non-small cell lung cancer patients
6. Enhancing arrest of cell growth to treat cancer in mice
7. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
8. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
9. Low forms of cyclin E reduce breast cancer drugs effectiveness
10. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
11. Soft drinks may increase risk of pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... The Calistoga Chamber of Commerce announces a brand new event ... March 27, through Sunday, March 29, 2015. The weekend-long experience ... and bar crawl, lodging and spa specials, yoga and dining ... older. , A variety of lodging and spa properties in ... offering Mudder of All Weekends packages featuring special room rates ...
(Date:3/3/2015)... 2015 The North America ... grow from $1,224.6 million to $1,694.6 million, ... and 2019. , Browse through the TOC ... for an analysis of industry trends and ... and figures., http://www.micromarketmonitor.com/market/north-america-application-delivery-network-adn-7381582251.html , An ...
(Date:3/3/2015)... Dallas plastic surgeon , Dr. ... upcoming Dallas Rhinoplasty Symposium, to be held March 6th ... is attended by plastic surgeons and otolaryngologists from around ... information on current topics, emerging techniques, best practices, and ... , The symposium will cover a diverse array ...
(Date:3/3/2015)... March 03, 2015 Splashtop Inc. ... announces Mirroring360 is now available for Epson® MoverioTM BT-200 ... the Moverio Apps Market , iPod, iPhone, and ... experience to the Epson Moverio smart glasses using Mirroring360, ... , The Epson smart glasses have an ...
(Date:3/3/2015)... 2015 Birth Boot Camp , ... now have over 130 certified instructors in more than ... In addition, the company recently launched a new ... educator certification program . Birth Boot Camp is unique ... partner. The practical information can be used by the ...
Breaking Medicine News(10 mins):Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 2Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 3Health News:Dr. Rod Rohrich to Chair 32nd Annual Dallas Rhinoplasty Symposium 2Health News:Dr. Rod Rohrich to Chair 32nd Annual Dallas Rhinoplasty Symposium 3Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 2Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 3Health News:Expectant Couples Worldwide Can Now Receive Training and Education in Natural Childbirth and Breastfeeding from Birth Boot Camp 2
... of milk as a child and during adulthood ... say researchers.,Norwegian investigators have found that childhood milk ... breast cancer before the menopause.Dr Annette Hjartaker and ... premenopausal Norwegian women. Participants were asked to complete ...
... testosterone levels in men with testicular cancer may ... US researchers.,A research team from North Carolina University ... down, a high rise in levels of amyloid ... occurs. They suggest that this phenomenon might explain ...
... and non toxic method of treating Hepatitis, by administering vitaminB ... liver, and in severe cases can lead to cirrhosis, liver ... the blood or body fluids of an infected person. ... very bright and aware patient observed that his aminotransferase levels ...
... increase the risk of a gastrointestinal bleed in older ... group of antidepressants which are very widely prescribed. They ... free of side effects. But, as Researchers at Ottawa ... risk-free.// ,Almost 314,000 patients aged ...
... diehard smokers may insist that they "enjoy" their ... believe them. Since smoking involves powerful physiological and ... help only a minority succeed. Even smoking cessation ... many, have been unable to keep the majority ...
... heart disease are twice as likely to have a better ... suggests. Researchers in a Swiss study looked at patients with ... ,Doctors either gave them medication, or referred them ... with a small inflatable balloon attached is inserted and the ...
Cached Medicine News:
(Date:3/3/2015)... Pa. , March 3, 2015   ... laboratory products, services and solutions, announced today the ... Biolabs®, Inc. (NEB®). This agreement allows VWR increased ... technical support in the U.S. and Puerto Rico.  ... NEB,s products through VWR,s e-business platform, sales organization, ...
(Date:3/3/2015)... TUCSON, Ariz. , March 3, 2015  The ... where more than 450 of the world,s top research scientists, ... findings, discuss evolving theories and learn about new outcomes ... of medicine. Each year Ventana Medical ... Roche Group, sponsors the Tucson Symposium at the ...
(Date:3/3/2015)... and NEW YORK , March 3, ... ), a biopharmaceutical company advancing protein biologic therapies and ... at the 27 th Annual ROTH Capital Partners ... at The Ritz-Carlton, Laguna Niguel in Dana Point, California.  ... Wehner , is scheduled to present a corporate update ...
Breaking Medicine Technology:VWR Announces Expansion of Distribution Agreement with New England Biolabs 2Global scientific collaborators to explore latest pathology and oncology advancements at Tucson Symposium 2PlasmaTech Biopharmaceuticals To Present at 27th Annual ROTH Capital Partners Conference 2
... DUSA Pharmaceuticals, Inc.(®) (Nasdaq GM: DUSA), a dermatology company ... and other products focused on patients with common skin ... Officer, will present a corporate overview at the Merriman ... 2009 at 10:00 a.m. ET at the Hotel Sofitel ...
... Nov. 6 Watson Pharmaceuticals, Inc. (NYSE: WPI ... Paul Bisaro, Watson,s president and chief executive officer, will ... at the Credit Suisse 18th Annual Healthcare Conference on ... Time. , This presentation will be webcast live and ...
Cached Medicine Technology:
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: