Navigation Links
UCI non-small cell lung cancer study highlights advances in targeted drug therapy
Date:11/1/2010

Orange, Calif., Nov 1, 2010 A UC Irvine oncologist's work with a targeted therapy is showing great promise in patients with a deadly form of lung cancer. The results were published Thursday in the New England Journal of Medicine.

The multicenter study is testing whether the drug crizotinib effectively slows, stops or reverses growth in advanced non-small cell lung cancer tumors by targeting a genetic mutation that causes uncontrolled tumor growth. Study participants all tested positive for a mutation in the anaplastic lymphoma kinase gene.

According to the findings, tumors disappeared or shrank in 57 percent of patients. Tumors ceased growing in another 33 percent. The response rate to the current standard of care for advanced non-small cell lung cancer is about 15 percent.

"For the majority of patients, the treatment right now is chemotherapy plus targeted therapy in those eligible," said Dr. Ignatius Ou. "In the future, with the advance of personalized medicine, we hope to be able to identify specific genetic change in the lung cancer and treat patients with specific inhibitors that can improve survival rates and quality of life."

The New England Journal of Medicine article includes data from 82 patients treated in Phase 1 of this study, sponsored by the pharmaceutical company Pfizer. The targeted genetic mutation is particularly prevalent among those who have never smoked. Study participants ranged in age from 25 to 78, with 76 percent of them nonsmokers.

Ou treated 15 patients in UCI's Phase 1 trial, most from Los Angeles, Orange and San Diego counties. One person came from Arizona each month for treatment and assessment. Ou is currently enrolling patients in Phase 2 and 3 trials for crizotinib. Interested candidates should contact the UCI clinical trials office at 714-456-6241.

Each year, about 1.5 million new cases of lung cancer are diagnosed globally. Nearly 75 percent of people wit
'/>"/>

Contact: John Murray
jdmurray@uci.edu
714-456-7759
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Research identifies patterns of CD24, a novel biomarker for non-small cell lung carcinomas
4. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
5. Comparision of overall survival for non-small cell lung cancer patients
6. Enhancing arrest of cell growth to treat cancer in mice
7. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
8. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
9. Low forms of cyclin E reduce breast cancer drugs effectiveness
10. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
11. Soft drinks may increase risk of pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... Diego, CA (PRWEB) June 02, 2015 “We ... from damaging ultraviolet (UV) sun rays”, states Marta Phillips, owner ... selection of men’s sun hats and sun accessories that work ... exposure are not immediately evident. Sometimes sun damage can take ... ears and neck are prime areas for skin cancer to ...
(Date:6/1/2015)... City, NY (PRWEB) June 02, 2015 ... honors Lynn Lester as a 2015-2016 inductee ... is recognized with this prestigious distinction for leadership in ... for professional women, boasting more than 700,000 members and ... honor Lynn Lester with this prestigious award,” said NAPW ...
(Date:6/1/2015)... The National Association of Professional Women ... 2015-2016 inductee into the NAPW VIP Professional Woman of ... distinction for leadership in academics. With more than 700,000 ... the nation’s leading networking organization exclusively for professional women. ... distinction,” said NAPW President Star Jones. “She is a ...
(Date:6/1/2015)... Garden City, NY (PRWEB) June 02, 2015 ... honors Linda Cade as a 2015-2016 ... She is recognized with this prestigious distinction for leadership ... exclusively for professional women, boasting more than 700,000 members ... to recognize Linda with this important honor,” said NAPW ...
(Date:6/1/2015)... Garden City, NY (PRWEB) June 02, 2015 ... honors Selma Tansey as a 2015-2016 ... She is recognized with this prestigious distinction for leadership ... organization exclusively for professional women, boasting more than 700,000 ... pleased to present Selma with this important honor," said ...
Breaking Medicine News(10 mins):Health News:It is Time to Show Father Who Knows Best, Says SunGrubbies.com, a Leading Online Sun Protection Retailer 2Health News:National Association of Professional Women Inducts Lynn Lester, Director of Clinical Operations/CEO, Recovery Treatment Center, Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Marcia Ditmyer, Vice President of Academy for Academic Leadership, Into its VIP Professional Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Linda Cade, Senior Product Manager at Sage, Into its VIP Professional Woman of the Year Circle 2Health News:NAPW Inducts Selma Tansey, Executive Director of Washington Communities Human Services, Into its VIP Professional Woman of the Year Circle 2
... ... ... ... ...
... likely to binge drink during pregnancy, researchers find , FRIDAY, ... to drink alcohol or binge drink than other adults, a ... 2004 to 2008 found that 44.3 percent of blacks aged ... of 55.2 percent. The rate of binge drinking among black ...
... associated with obesity may be largely restricted to tumors that ... in most colorectal cancers, according to a new study published ... Cancer Institute. This study was undertaken because little ... adult weight gain and the risk of colorectal cancer overall ...
... ... help reduce obesity levels in the UK. Overall physical activity has increased ... 28% of women meeting the recommended levels in 2006 (at least 30 ... week), compared with 32% and 21% respectively in 1997. MatchMySport ( www.matchmysport.com ...
... , ... ... ... ...
... Adults who have both diabetes and major depression are more ... with diabetes only, according to a study published in the ... is the progressive decline of thinking and reasoning abilities. These ... in the past, personality changes, and not recognizing familiar people. ...
Cached Medicine News:Health News:Blue Cross and Blue Shield of Minnesota Foundation Announces Funding Opportunity 2Health News:Blue Cross and Blue Shield of Minnesota Foundation Announces Funding Opportunity 3Health News:Blue Cross and Blue Shield of Minnesota Foundation Announces Funding Opportunity 4Health News:Blacks Less Likely to Abuse Alcohol 2Health News:High weight associated with risk of colorectal tumors without microsatellite instability 2Health News:MatchMySport.com Aims to Reduce Obesity Levels Through Sports Participation by Finding Sports Partners/Players/Teams 2Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 2Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 3Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 4Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 5Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 6Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 7Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 8Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 9Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 10Health News:Blue Cross and Blue Shield Companies To Host Fourth Annual National Walk@Lunch Day(R) on April 28, 2010 11Health News:Major depression more than doubles risk of dementia among adults with diabetes 2Health News:Major depression more than doubles risk of dementia among adults with diabetes 3
(Date:6/1/2015)... DUBAI , UAE, June 2, 2015 /PRNewswire/ ... to create the first, mainstream reporting standard for ... Principles. The next big step in CSR: The Islamic ... Launched only last month, the Islamic ... from across the Islamic world.  The latest members ...
(Date:6/1/2015)... June 1, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular ... highlights and financial results for the three months ... herein are in Canadian dollars unless otherwise stated. ... business strategies despite its limited financial resources," stated ...
(Date:6/1/2015)... The nuclear imaging market is estimated to ... of 12.08%. Nuclear medicine is the use of radioisotopes ... of Nuclear imaging used commonly are PET and SPECT. ... nuclear medicine applications like nuclear cardiology procedures. However, the ... shortage of molybdenum-99 isotope which is in turn will ...
Breaking Medicine Technology:Call for Partners: Islamic CSR 2Pivotal Therapeutics Announces First Quarter Financial Results 2Pivotal Therapeutics Announces First Quarter Financial Results 3Pivotal Therapeutics Announces First Quarter Financial Results 4Pivotal Therapeutics Announces First Quarter Financial Results 5North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 2North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 3
... Pa., Feb. 16, 2012 Medical Alarm Concepts Holding, ... medical alarm system that allows the user to speak ... with an update on current initiatives. The following comments ... President, Ronald Adams. "We have been working ...
... 2012  Ingenious Med, leaders in inpatient charge capture ... new business intelligence and data analysis solution. ... product offering, Imagine, is a comprehensive ... data to healthcare organizations. The analytics system measures ...
Cached Medicine Technology:Medical Alarm Concepts Investor Update -- News on Current Initiatives 2Medical Alarm Concepts Investor Update -- News on Current Initiatives 3Ingenious Med Introduces New Business and Data Analytics Solution 2
...
...
...
Open blade speculum designed for both temporal and superior approach ocular surgery. Thumb screw adjusting mechanism. Manufactured in titanium....
Medicine Products: