Navigation Links
UCI microbiologists find new approach to fighting viral illnesses
Date:8/22/2012

Irvine, Calif., Aug. 22, 2012 By discovering how certain viruses use their host cells to replicate, UC Irvine microbiologists have identified a new approach to the development of universal treatments for viral illnesses such as meningitis, encephalitis, hepatitis and possibly the common cold.

The UCI researchers, working with Dutch colleagues, found that certain RNA viruses hijack a key DNA repair activity of human cells to produce the genetic material necessary for them to multiply.

For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study led by microbiology & molecular genetics professor Bert Semler is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme to do so.

Study results appear in the early online edition of the Proceedings of the National Academy of Sciences the week of Aug. 20.

RNA viruses have ribonucleic acid as their genetic material (rather than deoxyribonucleic acid, or DNA). Notable human diseases caused by RNA viruses include SARS, influenza, hepatitis C, West Nile fever, the common cold and poliomyelitis.

The UCI and Dutch researchers examined one group of RNA viruses, called picornaviruses, using biochemical purification methods and confocal microscopy to see how they co-opt the functions of a cellular DNA repair enzyme called TDP2 to advance their replication process.

"These findings are significant because all known picornaviruses harbor the target for this DNA repair enzyme, despite the fact that their genetic material is made up of RNA rather than DNA. Thus, identifying drugs or small molecules that interfere with the interaction between the virus and TDP2 could result in a broad-spectrum treatment for picornaviruses," said Semler, who also directs UCI's Center for Virus Research.

By targeting a host cell function required for viral replication and not the virus itself, he added, the primary challenge of antiviral drug resistance may be sidestepped.

As part of their survival mechanism, RNA viruses mutate often, and drugs intended for them usually become ineffective over time. HIV, for example, rapidly mutates, necessitating a combination therapy employing a number of antiviral agents.

A drug that blocks RNA viruses from hijacking DNA repair enzymes may avoid these resistance issues. Semler's lab plans to screen mixtures of drug candidates to find ones that inhibit this process in cells infected by the human rhinovirus, the predominant cause of the common cold.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. NIH awards $7.8 million for innovative HIV vaccine approaches
2. Canada needs national approach to protect against drug shortages
3. A nonantibiotic approach for treating urinary tract infections
4. A hands-on approach to treating patients with pulmonary disease
5. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
6. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
7. MDC researchers develop new approach to treat acute liver failure
8. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
9. Study implements community-based approach to treat HIV-infection in rural Uganda
10. Expert panel calls for new research approach to prevent youth violence
11. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... April 27, 2017 , ... ... On the heels of Thinksport’s award-winning sunscreen they’ve used the same scientific approach ... works! , Countless deodorants flood the aisles that contain harmful chemicals that should ...
(Date:4/27/2017)... ... April 27, 2017 , ... Goodcents Deli Fresh Subs announced a ... Neb. area this year. , The first new location will open at the ... open at 84th and Northern Lights Drive this fall. And the third location is ...
(Date:4/26/2017)... MN (PRWEB) , ... April 26, 2017 , ... ... that improve supply management in hospitals, today announced it has completed a round ... Black Granite Capital LLC and its partners. Black Granite Capital is a growth ...
(Date:4/26/2017)... ... 2017 , ... CareSet Labs today is releasing an important ... Part D Medicare data. The dataset, called PaPR (Providers and Prescribing Records) details ... paper. The PaPR (pronounced "paper") data set aggregates this information on a ...
(Date:4/26/2017)... ... April 26, 2017 , ... Infertility may ... pelvic conditions and has helped many women become pregnant upon treating their diagnosis. ... office-based and simple outpatient evaluations. We can provide the necessary information to ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Research and Markets has announced the addition ... Addressing Production Complexities Through Risk Management and Quality by ... ... Market Prospects: Overcoming Production Complexities Through Risk Management and ... current trends in the global biosimilars market, with a ...
(Date:4/20/2017)... -- Research and Markets has announced the addition of ... Expanding Injectables Market and Increasing Usage of Complex Biologics during the ... ... from USD 20 Billion in 2015 to around USD 26 Billion ... Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of ...
(Date:4/20/2017)... Inc ., a digital health company focused on modernizing and ... $25 million in Series B funding led by Qiming US ... Seattle that is part of a broader family ... included participation from SR One , who led ZappRx,s ... Google Ventures). As part of the financing, Mark McDade ...
Breaking Medicine Technology: