Navigation Links
UCI microbiologists find new approach to fighting viral illnesses
Date:8/22/2012

Irvine, Calif., Aug. 22, 2012 By discovering how certain viruses use their host cells to replicate, UC Irvine microbiologists have identified a new approach to the development of universal treatments for viral illnesses such as meningitis, encephalitis, hepatitis and possibly the common cold.

The UCI researchers, working with Dutch colleagues, found that certain RNA viruses hijack a key DNA repair activity of human cells to produce the genetic material necessary for them to multiply.

For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study led by microbiology & molecular genetics professor Bert Semler is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme to do so.

Study results appear in the early online edition of the Proceedings of the National Academy of Sciences the week of Aug. 20.

RNA viruses have ribonucleic acid as their genetic material (rather than deoxyribonucleic acid, or DNA). Notable human diseases caused by RNA viruses include SARS, influenza, hepatitis C, West Nile fever, the common cold and poliomyelitis.

The UCI and Dutch researchers examined one group of RNA viruses, called picornaviruses, using biochemical purification methods and confocal microscopy to see how they co-opt the functions of a cellular DNA repair enzyme called TDP2 to advance their replication process.

"These findings are significant because all known picornaviruses harbor the target for this DNA repair enzyme, despite the fact that their genetic material is made up of RNA rather than DNA. Thus, identifying drugs or small molecules that interfere with the interaction between the virus and TDP2 could result in a broad-spectrum treatment for picornaviruses," said Semler, who also directs UCI's Center for Virus Research.

By targeting a host cell function required for viral replication and not the virus itself, he added, the primary challenge of antiviral drug resistance may be sidestepped.

As part of their survival mechanism, RNA viruses mutate often, and drugs intended for them usually become ineffective over time. HIV, for example, rapidly mutates, necessitating a combination therapy employing a number of antiviral agents.

A drug that blocks RNA viruses from hijacking DNA repair enzymes may avoid these resistance issues. Semler's lab plans to screen mixtures of drug candidates to find ones that inhibit this process in cells infected by the human rhinovirus, the predominant cause of the common cold.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. NIH awards $7.8 million for innovative HIV vaccine approaches
2. Canada needs national approach to protect against drug shortages
3. A nonantibiotic approach for treating urinary tract infections
4. A hands-on approach to treating patients with pulmonary disease
5. GWU consensus report outlines new approaches for evaluating benefits and risks of obesity drugs
6. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
7. MDC researchers develop new approach to treat acute liver failure
8. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
9. Study implements community-based approach to treat HIV-infection in rural Uganda
10. Expert panel calls for new research approach to prevent youth violence
11. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... CA (PRWEB) , ... February 27, 2017 , ... ... serving San Francisco and environs, is proud to announce an upgrade to the ... on the upgraded Yelp page on topics as diverse as Platelet Rich Plasma ...
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home care agency based ... and Palo Alto, is proud to announce an important upgrade to its geographic information ... home care close to home, and by having city-specific pages, NuevaCare is answering that ...
(Date:2/26/2017)... ... February 26, 2017 , ... Functional imaging data supports improved ... study released today at the 1st Pan American Parkinson’s and Movement Disorders Congress. ... effective in improving cognitive function in PD patients. This study, led by Ibarretxe-Bilbao ...
(Date:2/24/2017)... ... 2017 , ... Only two months after the official release of The Private ... (France), XO Private has initiated a second print-run of its lavish luxury travel coffee ... across when open, weighs in at more than six kilos, retails at EUR 1,000 ...
(Date:2/24/2017)... ... ... In the Health Care IT campaign, Robert Herjavec discusses health IT security ... will be attacked, but when.” However, he and many others involved highlight a promising ... in auditing and monitoring have taken security in health care a very long way. ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017  Interpace Diagnostics Group, ... provides clinically useful molecular diagnostic tests and pathology services, ... presented at the upcoming United States ... held March 4-10, 2017 in San Antonio, ... a review of data from the Company,s extensive experience ...
(Date:2/27/2017)... Fla. , Feb. 27, 2017 ... focused on developing cerebral embolic protection devices for ... the FDA,s Circulatory System Devices Panel that convened ... need for cerebral protection following transcatheter aortic valve ... by this FDA panel support the need for ...
(Date:2/27/2017)... 2017  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... focused on tissue protection, repair and regeneration, today ... Ltd., received a positive response from the U.S. ... for RGN-137 to treat epidermolysis bullosa ("EB"). RGN-137 ... Thymosin beta 4 ("Tß4") as the active pharmaceutical ...
Breaking Medicine Technology: