Navigation Links
UCI-led study links prenatal exposure to stress with accelerated cell aging
Date:8/1/2011

Irvine, Calif. Young adults whose mothers experienced psychological trauma during their pregnancies show signs of accelerated aging, a UC Irvine-led study found.

The researchers discovered that this prenatal exposure to stress affected the development of chromosome regions that control cell aging processes. The study results, which appear online this week in the Proceedings of the National Academy of Sciences, point to the importance of maternal health and well-being during pregnancy.

"Our previous research on prenatal stress exposure has shown its effects on long-term metabolic, immune, endocrine and cognitive function," said the paper's lead author, Dr. Pathik D. Wadhwa, UCI professor of psychiatry & human behavior, obstetrics & gynecology, pediatrics, and epidemiology. "But this is the first to show the impact of prenatal stress on cell aging in humans, and it sheds light on an important biological pathway underlying the developmental origins of adult disease risk."

Study participants were healthy 25-year-old women and men born to mothers who had, during pregnancy, experienced psychosocial stress in the form of major, traumatic life events, such as the death or sudden severe illness of an immediate family member. Blood tests revealed that subjects' white blood cells had aged an average of three and a half more years five among women than those of individuals whose mothers had uneventful pregnancies.

This hastened aging was evidenced by the shortened length of telomeres, repetitive stretches of DNA-protein complexes that cap and protect the ends of chromosomes. Telomeres maintain chromosomal stability and control the processes that underlie cellular aging by functioning as a "clock" that regulates how many times a cell can divide. The shorter the telomere strands, the faster the cell ages.

The telomere maintenance system plays an important role in human disease and longevity, and scientists now know that telomere length is correlated to the risk of disease and premature mortality in humans. Truncated telomeres such as those found in the white blood cells of study participants can, for example, be a precursor to diabetes, cancer and coronary heart disease.

"These results indicate that stress exposure in intrauterine life is a significant predictor of adult telomere length even after accounting for other established prenatal and postnatal influences on telomere length," said Sonja Entringer, UCI assistant professor of pediatrics and first author on the paper.

A rapidly emerging body of human and animal research indicates that intrauterine conditions play an important role not only in all aspects of fetal development and health across gestation and birth, but also in a wide range of physical and mental health outcomes over an individual's entire lifespan.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Novel stroke treatment passes safety stage of UCI-led clinical trial
2. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
3. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
4. TV drama can be more persuasive than news program, study finds
5. Study carried out into biological risks of eating reptiles
6. Neuroimaging study may pave way for effective Alzheimers treatments
7. Study finds racial gaps continue in heart disease awareness
8. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
9. First blinded study of venous insufficiency prevalence in MS shows promising results
10. Soothing infants with food focus of childhood obesity study
11. People with anxiety disorder less able to regulate response to negative emotions, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... ... new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the advanced skills needed to ... students from U.S. universities who will draw from Siemens’ deep knowledge of ...
(Date:2/12/2016)... ... 2016 , ... Each year, the American Physical Therapy Association (APTA) offers a ... Anaheim Convention Center. Almost 10,000 physical therapists across the country are expected to attend ... about their chosen field and network with their colleagues. As in years past, ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Zuckerberg San Francisco General Hospital on April 5-7. The series is a multi-day, ... new habits. The workshops cover a broad range of topics, including coaching skills, ...
(Date:2/12/2016)... , ... February 12, 2016 , ... AssureVest Insurance Group, ... is initiating a charity drive that will raise funds earmarked to purchase computers and ... Tayloe Elementary School. , “My school is in a low-income area and has more ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a full ... of the latest charity campaign in their community enrichment program. Art Expression utilizes ... worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... VIEJO , Kalifornien, 12. Februar 2016 /PRNewswire/ ... mit der Aufnahme von Patienten für eine Studie ... von Aneurysmen („WEB") speziell für die Behandlung von ... Spelle , MD, Leiter der Neuroradiologie an der ... Frankreich, und Hauptprüfarzt der CLARYS-Studie hat den ersten ...
(Date:2/12/2016)... ALISO VIEJO, Calif. , Feb. 12, 2016 /PRNewswire/ ... patient enrollment in a study to evaluate the safety ... specifically for the treatment of ruptured intracranial aneurysms.  Prof ... Bicetre University Hospital, in Paris, France ... the first patient. France ...
(Date:2/12/2016)... and SEOUL, South Korea ... Biosys­tems Menarini and Macrogen, Inc. today announced they ... and innovative procedures for precision medicine in cancer. ... Silicon Biosystems, DEPArray™ digital-sorting technology with Macrogen,s high-throughput ... tests certified under the Clinical Laboratory Improvement Amendments ...
Breaking Medicine Technology: