Navigation Links
UCI-led study links prenatal exposure to stress with accelerated cell aging
Date:8/1/2011

Irvine, Calif. Young adults whose mothers experienced psychological trauma during their pregnancies show signs of accelerated aging, a UC Irvine-led study found.

The researchers discovered that this prenatal exposure to stress affected the development of chromosome regions that control cell aging processes. The study results, which appear online this week in the Proceedings of the National Academy of Sciences, point to the importance of maternal health and well-being during pregnancy.

"Our previous research on prenatal stress exposure has shown its effects on long-term metabolic, immune, endocrine and cognitive function," said the paper's lead author, Dr. Pathik D. Wadhwa, UCI professor of psychiatry & human behavior, obstetrics & gynecology, pediatrics, and epidemiology. "But this is the first to show the impact of prenatal stress on cell aging in humans, and it sheds light on an important biological pathway underlying the developmental origins of adult disease risk."

Study participants were healthy 25-year-old women and men born to mothers who had, during pregnancy, experienced psychosocial stress in the form of major, traumatic life events, such as the death or sudden severe illness of an immediate family member. Blood tests revealed that subjects' white blood cells had aged an average of three and a half more years five among women than those of individuals whose mothers had uneventful pregnancies.

This hastened aging was evidenced by the shortened length of telomeres, repetitive stretches of DNA-protein complexes that cap and protect the ends of chromosomes. Telomeres maintain chromosomal stability and control the processes that underlie cellular aging by functioning as a "clock" that regulates how many times a cell can divide. The shorter the telomere strands, the faster the cell ages.

The telomere maintenance system plays an important role in human disease and longevity, and scientists now know that telomere length is correlated to the risk of disease and premature mortality in humans. Truncated telomeres such as those found in the white blood cells of study participants can, for example, be a precursor to diabetes, cancer and coronary heart disease.

"These results indicate that stress exposure in intrauterine life is a significant predictor of adult telomere length even after accounting for other established prenatal and postnatal influences on telomere length," said Sonja Entringer, UCI assistant professor of pediatrics and first author on the paper.

A rapidly emerging body of human and animal research indicates that intrauterine conditions play an important role not only in all aspects of fetal development and health across gestation and birth, but also in a wide range of physical and mental health outcomes over an individual's entire lifespan.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Novel stroke treatment passes safety stage of UCI-led clinical trial
2. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
3. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
4. TV drama can be more persuasive than news program, study finds
5. Study carried out into biological risks of eating reptiles
6. Neuroimaging study may pave way for effective Alzheimers treatments
7. Study finds racial gaps continue in heart disease awareness
8. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
9. First blinded study of venous insufficiency prevalence in MS shows promising results
10. Soothing infants with food focus of childhood obesity study
11. People with anxiety disorder less able to regulate response to negative emotions, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... London, ... was honored to serve earlier this month as a Guest Speaker and Contributor to ... British Royal Family and Common Purpose. , Walter Schindler and ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months ... officials call for diligence, asking homeowners to scout for any open water sources that ... with the annoying buzz of mosquitos is the buzz associated with potential infections stemming ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech ... in the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at ... NextGen LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients from Charleston, SC, are ... dentist practicing in Mt. Pleasant, SC, with or without a referral. A full mouth ... with missing teeth in Charleston, SC. Those who suffer from gum disease, ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... New ... gums and chronic bad breath, can now receive laser gum disease treatments from the ... Douglas Campbell and David Landau are raising awareness of the importance of receiving qualified ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)...  Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... focused on the development of oral drug delivery ... Office has granted Oramed a patent titled, "Methods ... patent covers Oramed,s invention of an oral glucagon-like ... incretin hormone that stimulates the secretion of insulin ...
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
(Date:5/4/2017)... , May 4, 2017  A recent study ... Ultraviolet-C light as a means of ... ability to reduce bioburden on anesthesia workstations. In ... on high-touch, complex medical equipment surfaces contaminated with ... "This study further validates the body ...
Breaking Medicine Technology: