Navigation Links
UCF researcher's nanoparticles could someday lead to end of chemotherapy
Date:6/16/2009

Nanoparticles specially engineered by University of Central Florida Assistant Professor J. Manuel Perez and his colleagues could someday target and destroy tumors, sparing patients from toxic, whole-body chemotherapies.

Perez and his team used a drug called Taxol for their cell culture studies, recently published in the journal Small, because it is one of the most widely used chemotherapeutic drugs. Taxol normally causes many negative side effects because it travels throughout the body and damages healthy tissue as well as cancer cells.

The Taxol-carrying nanoparticles engineered in Perez's laboratory are modified so they carry the drug only to the cancer cells, allowing targeted cancer treatment without harming healthy cells. This is achieved by attaching a vitamin (folic acid) derivative that cancer cells like to consume in high amounts.

Because the nanoparticles also carry a fluorescent dye and an iron oxide magnetic core, their locations within the cells and the body can be seen by optical imaging and magnetic resonance imaging (MRI). That allows a physician to see how the tumor is responding to the treatment.

The nanoparticles also can be engineered without the drug and used as imaging (contrast) agents for cancer. If there is no cancer, the biodegradable nanoparticles will not bind to the tissue and will be eliminated by the liver. The iron oxide core will be utilized as regular iron in the body.

"What's unique about our work is that the nanoparticle has a dual role, as a diagnostic and therapeutic agent in a biodegradable and biocompatible vehicle," Perez said.

Perez has spent the past five years looking at ways nanotechnology can be used to help diagnose, image and treat cancer and infectious diseases. It's part of the quickly evolving world of nanomedicine.

The process works like this. Cancer cells in the tumor connect with the engineered nanoparticles via cell receptors that
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCF researcher's nanoparticles could someday lead to end of chemotherapy
(Date:8/30/2014)... 2014: A new method to predict the optimal ... presented at ESC Congress today by Dr Benjamin Dahan ... 350 AEDs located in public places for optimal prevention ... Dahan said: "Out of hospital cardiac arrest is a ... between 50 and 100 per 100 000 in the ...
(Date:8/30/2014)... According to the latest review on DailyGossip.org, this ... for skin health. It seems that the method is so ... than 138,000 patients from all over the world. , ... this method will not only eliminate acne forever, but will ... makes this program unique among other methods of curing candida ...
(Date:8/30/2014)... August 31, 2014 Zensah®, the leader in ... sleeve emerge as a best-seller within golf and tennis. ... the activities they enjoy most by using the compression elbow ... elbow is a condition that causes pain on the ... forearm muscles attach to the bony bump on the inside ...
(Date:8/30/2014)... The Truth about Six Pack Abs is a new method ... shocking foods that can burn belly fat, unique workouts that ... as some motivation secrets for successful fitness. , The author ... trick that can help users reduce junk-food cravings. , ... think, cardio exercise routines are not the best to be ...
(Date:8/30/2014)... 2014 Information supplied by insurance companies ... better prices to consumers in 2014. A group of ... when using the open system for adults at ... to use this year can help the average person ... location and not from medical histories. The finder tool ...
Breaking Medicine News(10 mins):Health News:New method predicts optimal number and location of AEDs 2Health News:Acne No More Review Reveals Unusual Tip to Eliminate Acne Permanently 2Health News:Relieve Golfers and Tennis Elbow Pain with the Zensah® Compression Elbow Sleeve 2Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2Health News:Term Life Insurance Rates Now Found Nationally by New Insurer Finder Tool 2
... likely to get DVT, pulmonary embolisms , , TUESDAY, May ... the protein albumin in urine indicates an increased risk ... the lungs and legs, a Dutch study finds. , ... a clotting in the lower extremities which gained recent ...
... Mexico, may also be getting back to normal as flu ... health officials on Tuesday said that the current outbreak of ... severity, meaning that schools across the nation should remain open, ... This announcement marks a change from the previous guidance, which ...
... top officers at 2009 annual meeting in Las Vegas, NV. , ... ... Saltz, MD, is the new President of the American Society for Aesthetic ... is the leading national organization of board-certified plastic surgeons specializing in cosmetic ...
... May 5 With the H1N1 Virus outbreak intensifying ... the virus to cause difficult business conditions.To assist businesses ... the Greater Washington Board of Trade is issuing guidelines, ... website for resources.The Board of Trade recommends the following ...
... YORK, May 5 With global tobacco deaths climbing ... is heralding a 12.7 percent net revenue growth in ... tobacco epidemic are the same "emerging markets" that the ... of PMI,s 2008 surge, the international community moved to ...
... for oxygen, however, sometimes limits options, researcher says, , , ... a few weeks premature still have a much greater ... study has found. , Researchers for Kaiser Permanente found ... respiratory syncytial virus, or RSV -- especially among premature ...
Cached Medicine News:Health News:Urine Test Predicts Vein Clot Risk 2Health News:Urine Test Predicts Vein Clot Risk 3Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 2Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 3Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 4Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 5Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 6Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 7Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 8Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 9Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 10Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 11Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 12Health News:Swine Flu Appears Mild And Schools Should Stay Open, U.S. Officials Say 13Health News:Salt Lake City Plastic Surgeon is New President of American Society for Aesthetic Plastic Surgery 2Health News:Salt Lake City Plastic Surgeon is New President of American Society for Aesthetic Plastic Surgery 3Health News:Salt Lake City Plastic Surgeon is New President of American Society for Aesthetic Plastic Surgery 4Health News:Board of Trade Issues Business Preparation Guidelines for H1N1 Virus Outbreak 2Health News:Board of Trade Issues Business Preparation Guidelines for H1N1 Virus Outbreak 3Health News:Corporate Accountability International: Tobacco Giant Leads in Profits, Addicting Youth 2Health News:Corporate Accountability International: Tobacco Giant Leads in Profits, Addicting Youth 3Health News:Even Barely Early Babies Face Respiratory Risks 2
(Date:8/29/2014)... Aug. 29, 2014 Pomerantz LLP has filed ... the "Company") (NASDAQ: EDAP ) and certain ... States District Court, Southern District of New ... behalf of a class consisting of all persons or ... and July 30, 2014, inclusive (the "Class Period"). This class ...
(Date:8/29/2014)... , Aug. 29, 2014 Thoratec Corporation (NASDAQ: ... mechanical circulatory support therapies to save, support and restore ... the 2014 Morgan Stanley Global Healthcare Conference on Wednesday, ... President and Chief Executive Officer, will provide an update ... Time (9:55 a.m., Pacific Daylight Time).   ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... Disorders Drug Pipeline Insight 2014" report to their offering. ... in US is one of the largest segments of pharmaceuticals ... alarming rate, while the available therapies were unable to meet ... in the market for CNS disorder, especially over the past ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 3US CNS Disorders Drug Pipeline Insight 2014 2
... 11, 2012 Leading orthopaedic surgeon Simon ... operations to be filmed simultaneously from the surgeon,s viewpoint and ... is the first of its kind, has been developed by ... company which develops advanced medical devices, and is aimed at ...
... TOKYO, Jan. 11, 2012  Varian Medical Systems (NYSE: ... and software for the treatment of cancer, has established ... radiation oncologists, medical physicists, and technologists who work with ... established a clinical contact center (Help Desk), to provide ...
Cached Medicine Technology:Simon Moyes Pioneers New Keyhole Surgery Website 2Varian Medical Systems Establishes Radiotherapy Training Center and Clinical Help Desk in Tokyo, Japan 2Varian Medical Systems Establishes Radiotherapy Training Center and Clinical Help Desk in Tokyo, Japan 3
Serrated rake tip spatula with 20 gauge shaft. Black finish for reduced glare. Can be used with 20 gauge MVR blades....
Smooth, blunt round spatula for manipulations of the corneal flap. Ideal for placement under the flap to expose the stromal interface....
Wedge-shaped chopper designed to allow nucleus chopping in three directions, tip length 1.25 mm. Rounded tip highly polished to protect the posterior capsule. 0.5 mm spatula end is used to manipulate...
10 mm angled tip with indentation on side and gently curved blade. Round knurled handle with polished finish. Indentation: left side....
Medicine Products: