Navigation Links
UCF researcher's nanoparticles could someday lead to end of chemotherapy
Date:6/16/2009

Nanoparticles specially engineered by University of Central Florida Assistant Professor J. Manuel Perez and his colleagues could someday target and destroy tumors, sparing patients from toxic, whole-body chemotherapies.

Perez and his team used a drug called Taxol for their cell culture studies, recently published in the journal Small, because it is one of the most widely used chemotherapeutic drugs. Taxol normally causes many negative side effects because it travels throughout the body and damages healthy tissue as well as cancer cells.

The Taxol-carrying nanoparticles engineered in Perez's laboratory are modified so they carry the drug only to the cancer cells, allowing targeted cancer treatment without harming healthy cells. This is achieved by attaching a vitamin (folic acid) derivative that cancer cells like to consume in high amounts.

Because the nanoparticles also carry a fluorescent dye and an iron oxide magnetic core, their locations within the cells and the body can be seen by optical imaging and magnetic resonance imaging (MRI). That allows a physician to see how the tumor is responding to the treatment.

The nanoparticles also can be engineered without the drug and used as imaging (contrast) agents for cancer. If there is no cancer, the biodegradable nanoparticles will not bind to the tissue and will be eliminated by the liver. The iron oxide core will be utilized as regular iron in the body.

"What's unique about our work is that the nanoparticle has a dual role, as a diagnostic and therapeutic agent in a biodegradable and biocompatible vehicle," Perez said.

Perez has spent the past five years looking at ways nanotechnology can be used to help diagnose, image and treat cancer and infectious diseases. It's part of the quickly evolving world of nanomedicine.

The process works like this. Cancer cells in the tumor connect with the engineered nanoparticles via cell receptors that
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCF researcher's nanoparticles could someday lead to end of chemotherapy
(Date:4/22/2014)... ARBOR, Mich. Nearly 7 in 10 Americans ... a new national survey by researchers at the University ... with children under the age of 18 at home, ... more likely than other adults to support universal coverage ... appear in the Journal of the American Medical ...
(Date:4/22/2014)... patients diagnosed with non-small cell lung cancer are 70 ... percentage, these elderly patients are not well represented in ... made it difficult to reach evidence based clinical recommendations. ... Task Force and Lung Cancer Group along with the ... opinion on managing treatment for elderly patients with non-small ...
(Date:4/22/2014)... parallel with modern man ( Homo sapiens ), there were ... side by side, such as Neanderthals and the recently discovered ... survived. What was it in our genetic makeup that gave ... known about our unique genetic makeup as distinguished from our ... we are the only species among them ,to survive. Even ...
(Date:4/22/2014)... DC -- When mothers are exposed to trauma, illness, ... a single molecular trigger in brain cells that can ... stress disorder and some forms of autism. , Until ... have impacted the cells of a developing brain. Past ... herself to alcohol or drug abuse or she experiences ...
(Date:4/22/2014)... may be influenced by low exposure to testosterone in ... revealed how men,s testosterone levels may be determined before ... less of the hormone than others is important because ... of the hormone have been linked to obesity, diabetes ... cells responsible for producing testosterone in adults known ...
Breaking Medicine News(10 mins):Health News:More than two-thirds of Americans support mandated coverage of birth control in health plans 2Health News:EORTC and SIOG update expert opinion on management of elderly patients with NSCLC 2Health News:What gave us the advantage over extinct types of humans? 2Health News:Life stressors trigger neurological disorders, researchers find 2
... designed to treat chronic inflammatory conditions and leukemia resulted ... men involved in the trail becoming seriously ill. ... drug reaction. ,Dr. Ganesh Suntharalingam and colleagues ... immune system overreaction, known as a cytokine storm, was ...
... Clinton and Microsoft boss Bill Gates said inadequate access to ... combating the AIDS epidemic, in addresses to the largest ever ... continue to fight the stigma and stop people from being ... ,Both Clinton and Gates have donated billions of dollars ...
... be programmed to encourage fidgeting and other restless behaviors that ... research published by The American Physiological Society. ,The ... lean are more sensitive to a chemical produced in the ... such as fidgeting and other unconscious movements. Compared to rats ...
... good alternative for identifying risks for kidney disease, cardiovascular disease, ... a researcher at the San Francisco VA Medical Center, has ... incapable of picking up chronic health risks among the elderly., ... at risk for kidney disease, this is an important message: ...
... Neurosciences Institute in Rockville have claimed that the discovery ... patients// with Alzheimer's disease, could be developed as a ... ,The researchers explained that not only would be quick ... test for diagnosing Alzheimer's disease, which as of now ...
... Eighth International Conference on Mercury as a Global Pollutant, ... noted that Mercury pollution// can threaten the health of ... remote corners of the planet, but reducing mercury use ... declaration essentially says that mercury pollution is a problem ...
Cached Medicine News:Health News:Experimental Drug Causes Cytokine Storm 2Health News:Biological Basis Behind a Couch Potato 2Health News:Biological Basis Behind a Couch Potato 3Health News:Cystatin C Test- A Reliable Test to Detect Chronic Health Risks 2Health News:Cystatin C Test- A Reliable Test to Detect Chronic Health Risks 3Health News:Scientists Claim Developing A New Skin Test For The Early Detection Of Alzheimer’ 2Health News:Dangers Of Mercury 2
(Date:1/14/2014)... 2014 The Brandeis Medical Center, led by Dr. Emmanuel ... and affordable laser tattoo removal experience with the advanced Astanza Duality ... providing high quality cosmetic services with cutting edge medical technology and ... Southern California has seen a dramatic increase in the ...
(Date:1/14/2014)... Emergency Critical Care, a LifeCentre partner practice, located at 165 Fort ... first in Loudoun County to receive a ... M. Barnes , Medical Director, is a well-seasoned veterinarian of more ... , are avid scuba divers. "As altitude skiers and hikers, we ...
(Date:1/14/2014)... , Jan. 14, 2014   Oligomerix, Inc. , a ... therapeutics for Alzheimer,s disease (AD) and related neurodegenerative disorders, ... Valhalla, NY as of January ... space at New York Medical College. Oligomerix, ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Sevocity, a division of Conceptual MindWorks, Inc. (CMI), today ... as a preferred electronic health record (EHR) vendor with ... leading true Internet or cloud-based EHR. This enables Sevocity ... health record system with low start-up cost and affordable ...
... STAMFORD, Conn., July 20, 2011 A new online ... healthcare professionals, law enforcement, and community organizations combat the ... Purdue Pharma L.P . has developed RxSafetyMatters.org ... company and organizations with which it is partnering to ...
Cached Medicine Technology:Sevocity® Named Preferred EHR Vendor by CITIA-SC, South Carolina's Health IT Regional Extension Center (REC) 2New Online Resource to Help Combat Abuse of Prescription Medications Launched by Purdue Pharma L.P. 2New Online Resource to Help Combat Abuse of Prescription Medications Launched by Purdue Pharma L.P. 3
... System is designed to help physicians provide ... leg. Endovenous laser therapy is a patient-friendly ... of varicose veins., In endovenous laser therapy, ... the varicosed vein, generally through a small ...
ELVeS is a new minimally-invasive laser treatment for patients with superficial vein reflux of the greater saphenous vein. The ELVeS laser treatment offers your patients an effective out-patient alt...
Using proven 1064 nm technology for the treatment of deeper lesions, the Lumenis One Multi-Spot Nd:YAG module provides versatility allowing targeted treatment of leg veins, vascular lesions, facial w...
... #1 physician choice in laser treatment, brings ... superficial vein reflux. EVLT is a minimally ... stripping that effectively and safely treats varicose ... occlude the vein. The procedure is easy ...
Medicine Products: