Navigation Links
UCF researchers discover a new protein family implicated in inflammatory diseases
Date:3/10/2008

A University of Central Florida research team has discovered a new protein family that may play an important role in preventing inflammatory diseases such as arthritis, some forms of cancer and even heart disease.

The findings that in the future may aid the bodys defense system are published in the March 7 edition of the Journal of Biological Chemistry. The research is partially funded by the National Institutes of Health.

What we found is a family of proteins that control macrophage activation, researcher Mingui Fu said from a laboratory in the Burnett School of Biomedical Sciences at UCF.

Macrophages are the bodys self-cleaners. They live in the bloodstream and are called to action when bacteria or other foreign objects attack. Scientists have been studying what triggers them, but no one has come up with a step-by-step process yet. Once triggered, macrophages travel to the infection site and gobble up the invader, helping the body heal. The attack is manifested by inflammation at the infection site.

When everything works right, the inflammation goes away and the persons health improves. But when macrophages go awry, they can cause more harm than good. Sometimes the macrophages mistake the bodys own organs for invaders and attack, and that can cause arthritis or some forms of cancer. Sometimes the cleaners fail to detect threats, such as malignant cancer cells, which then go unregulated and can turn into fatal tumors.

When Fu arrived at UCF in 2007, he teamed up with Pappachan Kolattukudy, the director of the Burnett School of Biomedical Sciences. Kolattukudys laboratory has been studying for two decades how a small protein called MCP, produced at the site of injury, infection or inflammation, attracts macrophages to the site to clean up. Last year his team published the discovery of a novel gene called MCPIP that is turned on by MCP. They showed that MCPIP is involved in the development of ischemic heart failure, the leading cause of death. This team has been exploring how this new gene works.

MCPIP turns out to be the first member of a small, newly discovered gene family called CCCH-Zinc fingure proteins. This family appears to switch the macrophages on and off. The researchers continue to study different aspects of the proteins because of the possibility that they will be critical in treating and curing inflammatory diseases.

Kolattukudy said the new protein holds a lot of promise, but more studies are needed.

Because this novel protein has key roles to play in the major inflammatory diseases such as cardiovascular disease, cancer and obesity-induced type2 diabetes, it is a promising drug target, Kolattukudy said. We have a patent application filed on this protein for that purpose.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert

Related medicine news :

1. Size does matter: Researchers adapt drug dosing to body size
2. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
3. Researchers Design Promising Cancer Drug
4. Case Western Reserve University researchers identify colorectal cancer gene
5. On a roll: MIT researchers devise new cell-sorting system
6. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
7. Researchers control growth rate of replacement blood vessels, tissues
8. New protein discovery helps researchers understand autoimmune diseases
9. UF researchers warn parents about dangers of childhood foot burns
10. UCLA researchers find blood stem cells originate and are nurtured in the placenta
11. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
Breaking Medicine Technology: