Navigation Links
UCF researchers discover a new protein family implicated in inflammatory diseases
Date:3/10/2008

A University of Central Florida research team has discovered a new protein family that may play an important role in preventing inflammatory diseases such as arthritis, some forms of cancer and even heart disease.

The findings that in the future may aid the bodys defense system are published in the March 7 edition of the Journal of Biological Chemistry. The research is partially funded by the National Institutes of Health.

What we found is a family of proteins that control macrophage activation, researcher Mingui Fu said from a laboratory in the Burnett School of Biomedical Sciences at UCF.

Macrophages are the bodys self-cleaners. They live in the bloodstream and are called to action when bacteria or other foreign objects attack. Scientists have been studying what triggers them, but no one has come up with a step-by-step process yet. Once triggered, macrophages travel to the infection site and gobble up the invader, helping the body heal. The attack is manifested by inflammation at the infection site.

When everything works right, the inflammation goes away and the persons health improves. But when macrophages go awry, they can cause more harm than good. Sometimes the macrophages mistake the bodys own organs for invaders and attack, and that can cause arthritis or some forms of cancer. Sometimes the cleaners fail to detect threats, such as malignant cancer cells, which then go unregulated and can turn into fatal tumors.

When Fu arrived at UCF in 2007, he teamed up with Pappachan Kolattukudy, the director of the Burnett School of Biomedical Sciences. Kolattukudys laboratory has been studying for two decades how a small protein called MCP, produced at the site of injury, infection or inflammation, attracts macrophages to the site to clean up. Last year his team published the discovery of a novel gene called MCPIP that is turned on by MCP. They showed that MCPIP is involved in the development of ischemic heart failure, the leading cause of death. This team has been exploring how this new gene works.

MCPIP turns out to be the first member of a small, newly discovered gene family called CCCH-Zinc fingure proteins. This family appears to switch the macrophages on and off. The researchers continue to study different aspects of the proteins because of the possibility that they will be critical in treating and curing inflammatory diseases.

Kolattukudy said the new protein holds a lot of promise, but more studies are needed.

Because this novel protein has key roles to play in the major inflammatory diseases such as cardiovascular disease, cancer and obesity-induced type2 diabetes, it is a promising drug target, Kolattukudy said. We have a patent application filed on this protein for that purpose.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert

Related medicine news :

1. Size does matter: Researchers adapt drug dosing to body size
2. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
3. Researchers Design Promising Cancer Drug
4. Case Western Reserve University researchers identify colorectal cancer gene
5. On a roll: MIT researchers devise new cell-sorting system
6. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
7. Researchers control growth rate of replacement blood vessels, tissues
8. New protein discovery helps researchers understand autoimmune diseases
9. UF researchers warn parents about dangers of childhood foot burns
10. UCLA researchers find blood stem cells originate and are nurtured in the placenta
11. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: