Navigation Links
UCF researchers discover a new protein family implicated in inflammatory diseases
Date:3/10/2008

A University of Central Florida research team has discovered a new protein family that may play an important role in preventing inflammatory diseases such as arthritis, some forms of cancer and even heart disease.

The findings that in the future may aid the bodys defense system are published in the March 7 edition of the Journal of Biological Chemistry. The research is partially funded by the National Institutes of Health.

What we found is a family of proteins that control macrophage activation, researcher Mingui Fu said from a laboratory in the Burnett School of Biomedical Sciences at UCF.

Macrophages are the bodys self-cleaners. They live in the bloodstream and are called to action when bacteria or other foreign objects attack. Scientists have been studying what triggers them, but no one has come up with a step-by-step process yet. Once triggered, macrophages travel to the infection site and gobble up the invader, helping the body heal. The attack is manifested by inflammation at the infection site.

When everything works right, the inflammation goes away and the persons health improves. But when macrophages go awry, they can cause more harm than good. Sometimes the macrophages mistake the bodys own organs for invaders and attack, and that can cause arthritis or some forms of cancer. Sometimes the cleaners fail to detect threats, such as malignant cancer cells, which then go unregulated and can turn into fatal tumors.

When Fu arrived at UCF in 2007, he teamed up with Pappachan Kolattukudy, the director of the Burnett School of Biomedical Sciences. Kolattukudys laboratory has been studying for two decades how a small protein called MCP, produced at the site of injury, infection or inflammation, attracts macrophages to the site to clean up. Last year his team published the discovery of a novel gene called MCPIP that is turned on by MCP. They showed that MCPIP is involved in the development of ischemic heart failure, the leading cause of death. This team has been exploring how this new gene works.

MCPIP turns out to be the first member of a small, newly discovered gene family called CCCH-Zinc fingure proteins. This family appears to switch the macrophages on and off. The researchers continue to study different aspects of the proteins because of the possibility that they will be critical in treating and curing inflammatory diseases.

Kolattukudy said the new protein holds a lot of promise, but more studies are needed.

Because this novel protein has key roles to play in the major inflammatory diseases such as cardiovascular disease, cancer and obesity-induced type2 diabetes, it is a promising drug target, Kolattukudy said. We have a patent application filed on this protein for that purpose.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert

Related medicine news :

1. Size does matter: Researchers adapt drug dosing to body size
2. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
3. Researchers Design Promising Cancer Drug
4. Case Western Reserve University researchers identify colorectal cancer gene
5. On a roll: MIT researchers devise new cell-sorting system
6. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
7. Researchers control growth rate of replacement blood vessels, tissues
8. New protein discovery helps researchers understand autoimmune diseases
9. UF researchers warn parents about dangers of childhood foot burns
10. UCLA researchers find blood stem cells originate and are nurtured in the placenta
11. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... Today, June 27th is PTSD ... Yet less than 20% will receive adequate care due to lack of effective treatments, ... any care at all. And left untreated, veterans are at an increased risk for ...
(Date:6/27/2017)... ... June 27, 2017 , ... Children’s National Health System received top ... its Neonatology program ranking #1 out of more than 1500 neonatal intensive care ... coveted Honor Roll, a distinction given to the top performing children’s hospitals in the ...
(Date:6/26/2017)... San Diego, California (PRWEB) , ... June 26, ... ... Medical Director of Male Fertility & Sexual Medicine Specialists, in collaboration with the ... outpatient treatments for male fertility care: PESA (percutaneous epidydimal sperm aspiration) and TESA ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... leakage is revolutionizing the way women look and feel about themselves and their ... of female sexual dysfunction and urinary leakage head on with a ground breaking ...
(Date:6/26/2017)... Moscow, RU (PRWEB) , ... June 26, 2017 , ... ... released a whitepaper that pledges to solve many catastrophic issues within funding ... September 2017. , The typical notion of crowdfunding - the raising of funds through ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... , June 14, 2017  ivWatch LLC, a ... effectiveness of intravenous (IV) therapy, is pleased to announce ... category of Nonsurgical Hospital Supplies and Equipment at the ... program for the medtech industry. The award was presented ... Jacob K. Javits Center in New York ...
(Date:6/14/2017)... WINSTON-SALEM, N.C. , June 14, 2017  In ... the Creative Startups pitch competition and came ... virtual reality platform is described by Forbes as "entering ... the American Medical Association as teaching "empathy to medical ... success, the startup was recently named a finalist for ...
(Date:6/12/2017)... 12, 2017 Kineta, Inc., a biotechnology company focused ... Vice President of R&D and Head of Virology Kristin ... Preparedness for the Northwest and Beyond meeting sponsored by ... 14, 2017 from 8:30-10:30 AM PDT at the Agora Conference ... Dr. Bedard will be joined by other leaders in ...
Breaking Medicine Technology: