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UC San Diego researchers improve accuracy of breast cancer prognoses
Date:10/16/2007

eses in organisms for which sufficient protein interaction data have been measured, the authors write in their Molecular Systems Biology paper.

For example, the researchers show that a well-known breast cancer susceptibility gene, P53, plays a central role in several protein subnetworks; it interconnects many expression-responsive genes (genes that show up as potential markers in expression-only analyses). Interestingly, P53 itself does not show up as significant in conventional expression clustering or classification methods.

A key feature of our approach is the ability to identify crucial genes that fly under the radar of conventional gene expression analyses, said Ideker.

The phenotypic changes most indicative of breast cancer metastasis need not be regulated at the level of expression, the authors write.

The researchers also show that their subnetwork markers are significantly more reproducible between data sets than individual marker genes selected without network information.


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Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
Source:Eurekalert

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