Navigation Links
UC San Diego researchers identify factor boosting leukemia's aggressiveness
Date:10/22/2010

Chronic lymphocytic leukemia (CLL) cells survive and thrive not just by their own innate wiles, but by also acquiring aid and support from host cells in their surrounding environment. In a paper published online this week in The Proceedings of National Academy of Sciences, an international team of researchers led by cancer specialists at the University of California San Diego School of Medicine and the Moores UCSD Cancer Center identify a particular relationship that can promote notably aggressive leukemias and lymphomas.

"The microenvironment is the term used to describe the cells that cluster around CLL cells in the lymph nodes, spleen and bone marrow. These cells secrete factors that can protect CLL cells from dying," said Thomas J. Kipps, MD, PhD, Evelyn and Edwin Tasch Chair in Cancer Research, Professor of Medicine, Deputy Director of Research Operations at the Rebecca and John Moores UCSD Cancer Center and senior co-author of the paper with Michael Karin, PhD, Distinguished Professor of Pharmacology in UCSD's Laboratory of Gene Regulation and Signal Transduction.

Kipps, Karin and colleagues from Iowa, The Netherlands and Taiwan looked specifically at a protein called B-cell activating factor or BAFF, which is produced in high levels by "nurselike cells" in the CLL microenvironment. Nurselike cells are a subset of blood cells in CLL patients that help cancer cells avoid apoptosis or natural cell death. Kipps and colleagues first described this relationship in 2000.

The researchers found that BAFF interacts with a gene linked to leukemogenesis the development of leukemia called c-MYC. Normal MYC genes help regulate cell proliferation, but when upregulated or increased by mutations, c-MYC can promote more aggressive leukemias and lymphomas. To what degree this relationship influences CLL the most common form of adult leukemia remains unknown, though Kipps said the findings suggest therapeutic promise.

"We found that BAFF can upregulate expression of c-MYC in CLL cells and that patients who have CLL cells with high levels of c-MYC have aggressive disease," said Kipps. "These findings may lead to improvements in our ability to treat patients with CLL, either by blocking the effect of BAFF on CLL cells or inhibiting the signaling pathways triggered by BAFF that can lead to upregulation of MYC."


'/>"/>

Contact: Scott Lafee
slafee@ucsd.edu
619-543-6163
University of California -- San Diego
Source:Eurekalert

Related medicine news :

1. La Jolla Institute to develop San Diegos first center for RNAi genomics research
2. UC San Diego partners with Mozambique University to deliver quality health care
3. UC San Diego researcher awarded $3.8 million for new path to breast cancer therapy
4. Type 1 diabetes research at UC San Diego gets $5 million boost
5. UC San Diegos Karin receives prestigious Harvey Prize
6. APA presents latest research on same-sex marriage at annual convention in San Diego
7. UC San Diego researchers find cause of metabolic disease -- and possible cure
8. UC San Diego receives major clinical and translational science award
9. UC San Diego to lead new malaria research center in South America
10. World Renowned Total Artificial Heart Pioneer Dr. Jack Copeland Joins Faculty at UC San Diego
11. Nurtur Unveils the Third Dimension in Healthcare at SHRM 2010 Conference in San Diego
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... Manhattan New york (PRWEB) , ... April 28, ... ... is pleased to announce that Aditya Patel M.D. has joined the revolutionary endoscopic ... fellowship training and board certification in Interventional Pain Medicine. The patented, revolutionary eDiscSculpt ...
(Date:4/28/2017)... ... April 28, 2017 , ... People are starting to ... “Wearing a hearing aid doesn’t have the stigma it had when great-grandpa wore his ... of Greater Boston, in a NALA North American Speaker Series (NASS) segment. ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... their work assisting the Brooke Grove Foundation implement a Microsoft Dynamics GP solution ... Solutions, a leading ERP expert that specializes in long-term care, Brooke Grove now ...
(Date:4/28/2017)... ... ... Christie Medical Holdings, Inc. , with its market-leading vein finder ... a leader in infusion therapy and pain management. , Intravenous (IV) therapy plays ... patients receiving a peripheral IV catheter as part of their treatment plan. Many hospitals ...
(Date:4/27/2017)... Minnesota (PRWEB) , ... April 27, 2017 , ... ... and her husband Dan Gasby the 2017 Public Leadership in Neurology Award (PLINA). ... Woodruff, retired professional athlete Tedy Bruschi, Vice President Walter Mondale, actor Michael J. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017  IRIDEX Corporation (Nasdaq: IRIX ) ... the first quarter 2017 after the close of trading ... will host a corresponding conference call beginning at 2:30 ... interested in listening to the conference call may do ... (703) 326-3030 for international callers, using conference ID: 92158987.  ...
(Date:4/19/2017)... 19, 2017 Global Prostate Cancer Therapeutics ... the prostate cancer therapeutics market analyzes the current ... prevalence of prostate cancer, launch of promising emerging ... of new drugs & therapeutic biological products, and ... to lesser side effects are some of the ...
(Date:4/19/2017)... PUNE, India , April 19, 2017 ... Type and Application, Forecast to 2022 report has covered and ... provides statistics and information on market size, shares and growth ... with major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and ...
Breaking Medicine Technology: