Navigation Links
UC San Diego researcher awarded $5.3 million for breast cancer survivorship study

The University of California, San Diego School of Medicine has received a $5.3 million grant from the National Cancer Institute to conduct and lead a first-of-its-kind, four-year clinical trial to show the effects of weight loss and increased physical activity on quality of life and on co-existing medical conditions in overweight breast cancer survivors.

This trial is designed as a vanguard component of a larger study that will examine the effect of weight loss on recurrence risk for breast cancer survivors.

Cheryl Rock, PhD, RD, professor of Family and Preventive Medicine at the UCSD School of Medicine, will lead a multi-disciplinary team of experts representing five leading NCI-designated Comprehensive Cancer Centers including the Moores UCSD Cancer Center in this trial, also known as the ENERGY (Exercise and Nutrition to Enhance Recovery and Good Health for You) study.

"Excess body fat is a major adverse prognostic factor for women with both pre- and postmenopausal breast cancer," said Rock. "Up to 30 percent of breast cancer survivors experience anxiety or depression that persists after the completion of treatment. We believe weight loss and increased physical activity in overweight breast cancer survivors will have a positive effect on psychosocial problems and co-existing medical conditions, and may possibly reduce the risk of breast cancer recurrence."

Combining the investigators' experience in diet and exercise, cancer survivorship, nutritional epidemiology, breast oncology trials and breast cancer outcomes research, the team will conduct a randomized, controlled study that will track and measure improvements in quality of life and co-existing medical conditions in 800 overweight or obese breast cancer survivors.

Participants must be at least 21 years old and have been diagnosed with stage I, II, or IIIA breast cancer. They will be involved in a two-year active intervention program.

The weight-loss intervention uses a cognitive-behavioral group-based program, telephone counseling and home-based support that has been developed and tested in previous successful studies conducted by the ENERGY study's investigators.

"There are various goals of the ENERGY study," Rock said. "First, we are aiming for weight loss and maintenance among all 800 subjects, with a primary hypothesis that they will achieve an average weight reduction of at least seven percent of initial weight. We're also assessing the impact of the intervention on their quality of life, particularly physical functioning and fatigue." She added that the researchers will also conduct a cost-effectiveness analysis that includes an assessment of the impact of the intervention on medical co-existing conditions.

The investigators have strategically designed the ENERGY study to lead to an expanded full trial of 2,500 women. If the eventual full trial can document lower breast cancer recurrence risk, it would provide evidence to support weight loss management for breast cancer survivors as a new standard of clinical care.

"The ENERGY Study has great potential to have a major impact on clinical management and outcomes after a diagnosis of breast cancer," Rock said. "If the improvements in psychosocial and medical co-morbidities that we expect to find can be documented in this trial, this finding could itself change the norms of clinical practice and set a new aspect of care for breast cancer survivors after initial treatment."


Contact: Karen Shea
University of California - San Diego

Related medicine news :

1. Cymetrix to Provide Extended Business Office Services at UC San Diego Medical Center
2. U.S. HealthWorks in San Diego Region Offering $15 H1N1 Vaccinations for both Walk-Ins and On-Site
3. AIUM gears up for 2010 Annual Convention in San Diego, Calif.
4. AIUM gears up for 2010 Annual Convention in San Diego, California
5. San Diego Hospice and The Institute for Palliative Medicine on the Passing of Sol Price
6. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
7. In San Diego, Hispanics Now Dominate HIV/TB Cases
8. San Diego Unified School District Awarded Silent Hero Grant From got breakfast?(R) Foundation
9. Optelec Gets Creative: CSUN San Diego and VisionZone Premier with Special Movie Debut
10. Palladians Distinguished Clinicians Present at APTAs National CSM Convention in San Diego on Evidenced Informed Management of Chronic Low Back Pain Without Surgery
11. San Diego Cosmetic Dentists Launch New Website and Rejuvenate Online Image
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/27/2016)... ... ... recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
Breaking Medicine Technology: