Navigation Links
UC San Diego Superfund Research Program receives $15 million grant renewal

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, has renewed funding for the Superfund Research Program (SRP) at the University of California, San Diego. Over the next five years, the $15 million grant will fund continued research on the molecular and genetic consequences of exposure to uncontrolled toxicants from Superfund and other hazardous waste sites.

It is the third funding cycle for UC San Diego's SRP, which was originally funded by the NIEHS in 2000.

"The overall goal of the Superfund Research Program is to understand why environmental toxicants cause disease," said Robert H. Tukey, PhD, Professor of Pharmacology, Chemistry & Biochemistry at UC San Diego and Director of the UC San Diego SRP. "Our focus is on the development of novel biological models to define how toxicant exposure leads to illness and disease. We want to learn how to better detect toxicants and model the health effects of exposure, assess the risks, and find effective ways to remediate."

Since 2000, the SRP at UC San Diego has chalked some notable achievements. Most recently:

  • Michael Karin, PhD, Distinguished Professor of Pharmacology in UC San Diego's Laboratory of Gene Regulation and Signal Transduction, has identified initiating cells in the liver that progress into liver cancer following exposure to chemical carcinogens. The identity of these cells may lead to an understanding of the mechanisms that underlie the development of liver cancer.
  • Robert Tukey, PhD has produced new mouse models expressing human genes that result in dramatically elevated levels of serum bilirubin, a potent and natural antioxidant that can be used to study the role of oxidative stress in toxicant-induced disease.
  • Julian Schroeder, PhD, in the Biology Department at UC San Diego, has used the plant model Arabidopsis to create genetically engineered plants that may eventually prove useful to bioaccumulate heavy metals from contaminated soils on a commercially viable scale.
  • David Brenner, MD, vice chancellor of UC San Diego Health Sciences, and Dean of the UCSD School of Medicine, and Ekihiro Seki, MD, from the Department of Medicine, have investigated the genetic mechanisms that lead to the development of toxicant induced liver fibrosis.
  • Ronald Evans, PhD, at the Salk Institute, has identified key cellular receptors that serve to transport environmental toxicants to the nucleus, allowing for identification of the genes that may lead to disease.
  • Paul Russell, PhD, at the Scripps Research Institute, has been successful in using yeast to characterize intracellular proteins important in arsenic induced toxicity.
  • William Trogler, PhD, Professor of Chemistry and Biochemistry, has developed novel chemical tools to detect toxicant exposure in the environment.

On-going and future projects, said Tukey, will use functional genomics and proteomics to investigate the cellular and molecular responses leading to toxicant -induced liver toxicity.

The SRP at UC San Diego is broad-based, with biomedical researchers, chemists, plant biologists, and public outreach experts. It includes research projects led by scientists from other institutions, including The Scripps Research Institute, the Salk Institute for Biological Studies and the Howard Hughes Medical Institute.

Contact: Scott LaFee
University of California - San Diego

Related medicine news :

1. UC San Diego among first in nation to treat brain cancer with novel viral vector
2. UC San Diegos William C. Mobley recognized for contributions to Down syndrome
3. AAAS Pacific Division to convene joint session with world mummy scholars in San Diego
4. Study finds Filipino children in San Diego County at higher risk for Kawasaki disease
5. UC San Diego receives 2 major biomedical informatics grants
6. UC San Diego researchers identify factor boosting leukemias aggressiveness
7. La Jolla Institute to develop San Diegos first center for RNAi genomics research
8. UC San Diego partners with Mozambique University to deliver quality health care
9. UC San Diego researcher awarded $3.8 million for new path to breast cancer therapy
10. Type 1 diabetes research at UC San Diego gets $5 million boost
11. UC San Diegos Karin receives prestigious Harvey Prize
Post Your Comments:
Related Image:
UC San Diego Superfund Research Program receives $15 million grant renewal
(Date:11/25/2015)... ... November 25, 2015 , ... "When I underwent ... bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In order to ... the patent-pending RECOVERY BRA for added comfort and support. The bra is easier ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch ... solutions involving adult stem cell therapies to patients with chronic degenerative medical conditions. ... as a Registered Trademark (RTM). , Organizations are required to hold a registered ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA , ... now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. This ... cutting tools, such as the scalpel and high-speed drill, which can both cause patients ...
(Date:11/24/2015)... Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... explored the different restrictions and variables that determine which patients are or are not ... those patients that have a BMI over 40, are more than 100 pounds overweight, ...
(Date:11/24/2015)... City, UT (PRWEB) , ... November 24, 2015 , ... ... Forbes Magazine. For a business, it is critical that the first impression be positive ... business, they are not likely to buy anything or want to return. They will ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 --> ... eine Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, ... ENS-Lyon innehaben, an Enyo Pharma vergeben haben. ... Leben gerufenen und von Edelris gemeinsam mit seinen Partnern ... Behandlungsziel für HBV identifiziert, und es wurden neue Inhaltsstoffe ...
(Date:11/24/2015)... 24, 2015  Natera, Inc. (Nasdaq: ... testing and the analysis of circulating cell-free ... at the 27 th  Annual Piper Jaffray ... p.m. ET.  Matthew Rabinowitz, Ph.D., CEO of Natera, ... activities and financial outlook.  ...
(Date:11/24/2015)... York , 24. November 2015 /PRNewswire/ ... Avery Breathing Pacemaker Systems, ist erfreut, die ... Clinical Consultant bekannt geben zu können. ...   --> Foto - ... (Schweden). Von 1984-1986 war er ...
Breaking Medicine Technology: