Navigation Links
UC San Diego Superfund Research Program receives $15 million grant renewal
Date:5/22/2012

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, has renewed funding for the Superfund Research Program (SRP) at the University of California, San Diego. Over the next five years, the $15 million grant will fund continued research on the molecular and genetic consequences of exposure to uncontrolled toxicants from Superfund and other hazardous waste sites.

It is the third funding cycle for UC San Diego's SRP, which was originally funded by the NIEHS in 2000.

"The overall goal of the Superfund Research Program is to understand why environmental toxicants cause disease," said Robert H. Tukey, PhD, Professor of Pharmacology, Chemistry & Biochemistry at UC San Diego and Director of the UC San Diego SRP. "Our focus is on the development of novel biological models to define how toxicant exposure leads to illness and disease. We want to learn how to better detect toxicants and model the health effects of exposure, assess the risks, and find effective ways to remediate."

Since 2000, the SRP at UC San Diego has chalked some notable achievements. Most recently:

  • Michael Karin, PhD, Distinguished Professor of Pharmacology in UC San Diego's Laboratory of Gene Regulation and Signal Transduction, has identified initiating cells in the liver that progress into liver cancer following exposure to chemical carcinogens. The identity of these cells may lead to an understanding of the mechanisms that underlie the development of liver cancer.
  • Robert Tukey, PhD has produced new mouse models expressing human genes that result in dramatically elevated levels of serum bilirubin, a potent and natural antioxidant that can be used to study the role of oxidative stress in toxicant-induced disease.
  • Julian Schroeder, PhD, in the Biology Department at UC San Diego, has used the plant model Arabidopsis to create genetically engineered plants that may eventually prove useful to bioaccumulate heavy metals from contaminated soils on a commercially viable scale.
  • David Brenner, MD, vice chancellor of UC San Diego Health Sciences, and Dean of the UCSD School of Medicine, and Ekihiro Seki, MD, from the Department of Medicine, have investigated the genetic mechanisms that lead to the development of toxicant induced liver fibrosis.
  • Ronald Evans, PhD, at the Salk Institute, has identified key cellular receptors that serve to transport environmental toxicants to the nucleus, allowing for identification of the genes that may lead to disease.
  • Paul Russell, PhD, at the Scripps Research Institute, has been successful in using yeast to characterize intracellular proteins important in arsenic induced toxicity.
  • William Trogler, PhD, Professor of Chemistry and Biochemistry, has developed novel chemical tools to detect toxicant exposure in the environment.

On-going and future projects, said Tukey, will use functional genomics and proteomics to investigate the cellular and molecular responses leading to toxicant -induced liver toxicity.

The SRP at UC San Diego is broad-based, with biomedical researchers, chemists, plant biologists, and public outreach experts. It includes research projects led by scientists from other institutions, including The Scripps Research Institute, the Salk Institute for Biological Studies and the Howard Hughes Medical Institute.


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. UC San Diego among first in nation to treat brain cancer with novel viral vector
2. UC San Diegos William C. Mobley recognized for contributions to Down syndrome
3. AAAS Pacific Division to convene joint session with world mummy scholars in San Diego
4. Study finds Filipino children in San Diego County at higher risk for Kawasaki disease
5. UC San Diego receives 2 major biomedical informatics grants
6. UC San Diego researchers identify factor boosting leukemias aggressiveness
7. La Jolla Institute to develop San Diegos first center for RNAi genomics research
8. UC San Diego partners with Mozambique University to deliver quality health care
9. UC San Diego researcher awarded $3.8 million for new path to breast cancer therapy
10. Type 1 diabetes research at UC San Diego gets $5 million boost
11. UC San Diegos Karin receives prestigious Harvey Prize
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC San Diego Superfund Research Program receives $15 million grant renewal
(Date:10/13/2017)... EDWARDSVILLE, Ill. (PRWEB) , ... ... ... University Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and ... educated healthcare professionals on guideline updates for the primary prevention of cardiovascular ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
Breaking Medicine Technology: