Navigation Links
UC Irvine study points to new approach to influenza's antiviral resistance
Date:7/13/2011

Researchers from the University of California, Irvine, with assistance from the San Diego Supercomputer Center at UC San Diego, have found a new approach to the creation of customized therapies for virulent flu strains that resist current antiviral drugs.

The findings, published online this week in Nature Communications, could aid development of new drugs that exploit so-called flu protein 'pockets.'

Using powerful computer simulations on SDSC's new Trestles system, launched earlier this year under a $2.8 million National Science Foundation (NSF) award, UCI's Rommie Amaro and Robin Bush together with SDSC's Ross Walkercreated a method to predict how pocket structures on the surface of influenza proteins promoting viral replication can be identified as these proteins evolve, allowing for possible pharmaceutical exploitation.

"Our results can influence the development of new drugs taking advantage of this unique feature," said Amaro, an assistant professor of pharmaceutical sciences and computer science at UCI. Prior to joining UCI in 2009, Amaro was a postdoctoral fellow in chemistry at UC San Diego.

The search for effective flu drugs has always been hampered by the influenza virus itself, which mutates from strain to strain, making it difficult to target with a specific pharmaceutical approach. The most common clinical flu treatments are broad-based and only partially effective. They work by interrupting the action of an enzyme in the virus called neuraminidase, which plays a critical role in viral replication.

In 2006, scientists discovered that avian influenza neuraminidase (N1) exhibited a distinctive, pocket-shaped feature in the area pinpointed by clinically used drugs. They named it the 150-cavity.

Amaro and Bush, associate professor of ecology and evolutionary biology, conducted research using resources at the San Diego Supercomputer Center, as well as the National Institute for Computational S
'/>"/>

Contact: Jan Zverina
jzverina@sdsc.edu
858-534-5111
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UC Irvine Medical Center honors 9 for nursing excellence
2. UC Irvine Medical Center recognized for heart failure program
3. UC Irvine Medical Center is recognized for its commitment to organ donation
4. VOICE study will continue as it considers what action to take after results of 2 trials
5. Pivotal study in Africa finds that HIV medications prevent HIV infection
6. UAB researchers present a study on the psychological adaptation of adopted children
7. Bed Sores Afflict More Blacks in Nursing Homes Than Whites: Study
8. More U.S. Men Die From Cancer Than Women: Study
9. Older Women at Greater Risk for Common STD, Study Suggests
10. Bladder Cancer Patients Not Getting Recommended Care: Study
11. Fast Food Is King of the Neighborhood, Study Reports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... April 18, 2015 Insuranceautoquote.info has released ... online auto insurance quotes . , Clients can ... single website. The online environment provides important advantages for ... , Drivers who do not have coverage for ... during any season, day or hour. Many agencies offer ...
(Date:4/18/2015)... Thousand of DePuy Pinnacle hip lawsuits ... who were allegedly harmed by a metal-on-metal version of ... the U.S. District Court, Northern District of Texas. According ... amended an earlier Case Management Order to allow for ... new amendment permits the claims of up to 150 ...
(Date:4/18/2015)... April 18, 2015 Aureus Medical ... staffing, including physical therapy jobs, has announced that ... South Carolina Physical Therapy Association Annual Conference to ... Center in Greenville, SC. , The SCAPTA ... exhibits with products and services. , Representatives ...
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant ... Week Celebration on April 20 with a day full ... body and soul. , The community, which is located ... adults of all incomes, including those on Medicaid, who ... Living Week is observed every April and highlights the ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Riviera ... Dr. Kevin Sadati of the Gallery of Cosmetic ... County’s top beauty experts. The publication focused on ... facial stem cell fat grafting, eyelid surgery, laser resurfacing ... facial plastic surgery has resulted in thousands of ...
Breaking Medicine News(10 mins):Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3
... BEIJING, Feb. 26 /Xinhua-PRNewswire-FirstCall/ -- Lotus,Pharmaceuticals, Inc. (OTC ... holding company in the United States that operates ... Zhe Jia Shi Pharmaceutical,Co., Ltd. both of which ... ("PRC"), today announced that it has raised $5 ...
... 26 , WHO: New York Lt. Gov. David A. Paterson, along with stem cell experts ... M.D., will be the keynote speakers at the 3rd Annual Stem Cell ... February 26 Hilton New ... 1335 Avenue of the Americas, ...
... Feb. 26 /PRNewswire-FirstCall/ - Bradmer Pharmaceuticals ... development and,commercialization of cancer therapies, today ... Company,s Neuradiab product candidate as a ... were published in the journal,Neuro-Oncology.,( http://neuro-oncology.dukejournals.org/cgi/rapidpdf/15228517-2007-053v1 ...
... China,Bionanometer Industries Corporation (Pink Sheets: CBIU), a ... introduce new products in 2008,after nearly one ... the prevention and treatment of influenza -- ... Influenza is an eternal and worldwide ...
... Core ... Merger Paying Off: Q4 Gross Margin of 33% & Record 23% EBITDA Margin ... (Adjusted), ... of communication services in Israel, today,reported its financial results for the fourth quarter and full ...
... Cardiology1 and the European Heart Network2 this month, highlighted ... One fact, nevertheless, remains the same: cardiovascular disease (CVD) ... Union, killing over 2 million people per year. CVD ... Many of these deaths could be averted with ...
Cached Medicine News:Health News:Lotus Pharmaceuticals Raises $5 Million in Private Placement 2Health News:Lotus Pharmaceuticals Raises $5 Million in Private Placement 3Health News:MEDIA ADVISORY: New York Lt. Gov. David Paterson and Stem Cell Experts to Participate in 3rd Annual Stem Cell Summit 2Health News:Bradmer announces Phase II results published in newly diagnosed glioblastoma which demonstrate improved survival and support upcoming Phase III study 2Health News:Bradmer announces Phase II results published in newly diagnosed glioblastoma which demonstrate improved survival and support upcoming Phase III study 3Health News:Bradmer announces Phase II results published in newly diagnosed glioblastoma which demonstrate improved survival and support upcoming Phase III study 4Health News:China Bionanometer Industries Corporation Announces New Products for China 2Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 2Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 3Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 4Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 5Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 6Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 7Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 8Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 9Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 10Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 11Health News:012 Smile.Communications Reports Financial Results for Q4 and Full Year 2007 12Health News:The human and economic cost of heart disease in Europe 2Health News:The human and economic cost of heart disease in Europe 3
(Date:4/17/2015)... 17, 2015 Research and Markets ( ... "Medical Equipment Rental and Leasing - Global Strategic Business ... report analyzes the worldwide markets for Medical Equipment Rental ... comprehensive analytics for the US, Japan ... World. Annual estimates and forecasts are provided ...
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... of the "Mammography Equipment - Global Strategic Business ... report analyzes the worldwide markets for Mammography Equipment in ... Equipment, and Digital Mammography Equipment. The report provides separate ... , Japan , Europe ...
(Date:4/17/2015)... 16, 2015 Research and Markets ( ... "Corporate Reputation of Pharma in 2014 - a Perspective ... to their offering. This independent study, funded ... groups with an interest in diabetes on the corporate ... pharma industry as a whole) in 2014. The results ...
Breaking Medicine Technology:Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2Mammography Equipment (Analog & Digital) Market 2015-2020 - Global Strategic Business Report: Breast Imaging Screening Programs Push Sales 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5
... Award, and Golden Globe Award-nominated actress Lorraine Bracco will appear on ... program that tells the compelling and inspirational stories of real patients. Sharing ... , , ... mob wife Karen Hill in the critically acclaimed film Goodfellas ...
... ,, SHENZHEN, China , May 6 ... a leading manufacturer of medical dressings,medical disposables and non-woven PurCotton(R) materials for ... Brean,Murray, Carret & Co. Life Sciences Summit in New York ... , Date: Monday, May ...
Cached Medicine Technology:'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 2'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 3'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 4'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 5'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 6'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 7'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 8'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 9'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 10'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 11'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 12'Sharing Miracles' Television Program to Feature Academy Award Nominee Lorraine Bracco 13Winner Medical Group Inc. to Attend the 2010 Brean Murray, Carret & Co. Life Sciences Summit in New York 2Winner Medical Group Inc. to Attend the 2010 Brean Murray, Carret & Co. Life Sciences Summit in New York 3Winner Medical Group Inc. to Attend the 2010 Brean Murray, Carret & Co. Life Sciences Summit in New York 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: