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UC-Irvine scientists present groundbreaking research at Society for Neuroscience conference
Date:11/3/2007

ed off in people with fragile X syndrome. This genetic mutation disrupts cellular processes that are needed for memory formation. The researchers found that by adding brain-derived neurotrophic factor proteins to the hippocampus region of fragile X syndrome test mice, memory-forming capacities of the brain cells were completely restored. The findings suggest the possibility of fragile X syndrome therapies that allow for increased learning and memory.

Poster: Hippocampal LTP is impaired in a mouse model of Fragile X syndrome and rescued by Brain Derived Neurotropic Factor

UCI Expert: Julie Lauterborn, associate researcher in anatomy and neurobiology, UC Irvine

When: 11 a.m. Noon Monday, Nov. 5

Where: Poster 362, LTP: Postsynaptic Mechanisms; San Diego Convention Center Halls B-H

MRI Can Help Identify Cognitive Deficits Following Febrile Seizures UC Irvine epilepsy researchers have used MRI to identify the changes in brain cells marking the cognitive deficits following febrile seizures. This discovery shows for the first time a potential marker of children who might be at risk for brain dysfunction after long febrile seizures. Febrile seizures, convulsions associated with fever, are the most common seizures that occur in infants and children. In this study, the researchers performed MRI tests on the brains of baby rats after they experienced an experimental febrile seizure and found a correlation between brain cell changes and performance on a learning/memory test. Test results point toward early recognition and care of children who are at risk for cognitive problems after long febrile seizures. Poster: Are MRI changes predictive of cognitive deficits after experimental prolonged febrile seizures? UCI Experts: Celine Dub, project scientist in anatomy and neurobiology, UC Irvine; Dr. Tallie Z. Baram, the Danette Shepard Chair in Neurological Sciences, UC Irvine When: 11 a.m. - Noon. Monday, Nov. 5 Where: Poster 375, Epilepsy: Animal Model
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Contact: Tom Vasich
tmvasich@uci.edu
949-285-6455
University of California - Irvine
Source:Eurekalert

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