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UC-Irvine scientists present groundbreaking research at Society for Neuroscience conference
Date:11/3/2007

mage to the DNA and RNA of brain cells, UC Irvine researchers discovered in a study of people older than 90. The two antioxidant vitamins were associated with decreased oxidative damage to brain cells in the frontal cortex. The researchers found that better cognitive performance in elderly subjects is associated with lower levels of oxidative DNA and RNA damage in the brain, and that those taking multivitamins including vitamins E or C tended to perform better on a test of global cognitive ability.

Poster: Cognitive performance, dementia and DNA/RNA oxidative damage in the oldest-old

UCI Experts: Elizabeth Head, assistant professor of neurology; Lori-ann Christie, postdoctoral researcher in the Institute of Brain Aging and Dementia, UC Irvine

When: 2-3 p.m. Sunday, Nov. 4

Where: Poster 256, Oxidative Stress and Synaptic Transmission; San Diego Convention Center Halls B-H


Nicotine Patch May Have Same Effect as Smoking on Pregnancy

Use of the nicotine patch during pregnancy may produce the same types of neurobehavioral deficits that result from maternal smoking, UC Irvine researchers found. Its well documented that maternal smoking has been linked to lasting deficits in offspring. As a result, many physicians now recommend that pregnant smokers use the nicotine patch as a safer alternative to tobacco during pregnancy. However, UC Irvine researchers found that sustained prenatal exposure to low doses of nicotine, similar to that seen with the nicotine patch, produces substantial changes in the brains of adolescent offspring. Tests with pregnant rats show that nicotine exposure during gestation has marked effects on the maturation of the adolescent brain similar to those resulting from maternal smoking.

Poster: Gestational nicotine exposure induces region-specific, sex-dependent changes in adolescent dopamine systems

UCI Experts: Jennifer Dwyer, graduate researcher in pharmacology, UC Irvine; Frances M. Leslie, p
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Contact: Tom Vasich
tmvasich@uci.edu
949-285-6455
University of California - Irvine
Source:Eurekalert

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