UC-Irvine scientists present groundbreaking research at Society for Neuroscience ...(n do not communicate correctly with each...),Health

Minisymposium: Not Just a Genotype: The Mouse as a Model for Auditory Systems Neuroscience UCI Expert: Raju Metherate, associate professor of neurobiology and behavior, UC Irvine

When: 9:15-9:35 a.m. Sunday, Nov. 4

Where: Minisymposium 110, Thalamocortical Processing: Mechanisms and Modulation; San Diego Convention Center Room 30E

Vitamin B3 Restores Memory Loss Associated with Alzheimers Disease

New research shows that Vitamin B3, also called nicotinamide, can restore memory loss associated with Alzheimers disease. UCI scientists gave this water-soluble vitamin to mice bred to develop plaques and tangles, the two brain lesions that characterize Alzheimers disease. Mice that received the treatment had lower levels of phosphorylated tau, a protein in the brain that can lead to the development of tangles, than untreated mice. These findings suggest that Vitamin B3, often used in energy drinks, might be a safe and effective therapy for people with Alzheimers disease. UC Irvine has received funding to conduct a clinical trial to test Vitamin B3 in humans with the disease.

Poster: Oral Nicotinamide Treatment Induces Ubiquitin-dependent degradation of phospho-tau and restores cognitive function in a mouse model of Alzheimer disease

UCI Experts: Kim Green, project scientist in neurobiology and behavior; Frank LaFerla, professor of neurobiology and behavior; Leslie Thompson, associate professor of psychiatry and human behavior; Joan Steffan, assistant professor of psychiatry, UC Irvine

When: 10-11 a.m. Sunday, Nov. 4

Where: Poster 157, Alzheimers Disease and Other Dementias: Therapies II; San Diego Convention Center Halls B-H

Vitamins E and C Supplements Limit Oxidative Brain Cell Damage, Cognitive Dysfunction

Supplementation with vitamins E and C appears to limit the da
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