Navigation Links
UC Davis researchers refine nanoparticles for more accurate delivery of cancer drugs
Date:1/19/2012

(SACRAMENTO, Calif.) -- A new class of nanoparticles, synthesized by a UC Davis research team to prevent premature drug release, holds promise for greater accuracy and effectiveness in delivering cancer drugs to tumors. The work is published online in Angewandte Chemie, a leading international chemistry journal.

In their paper, which will be featured on the inside back cover of the journal, Kit Lam, professor and chair of the Department of Biochemistry and Molecular Medicine, and his team report on the synthesis of a novel class of micelles called dual-responsive boronate cross-linked micelles (BCMs), which produce physicochemical changes in response to specific triggers.

A micelle is an aggregate of surfactant molecules dispersed in water-based liquid such as saline. Micelles are nano-sized, measuring about 25-50 nanometers (one nanometer is one billionth of a meter), and can function as nanocarriers for drug delivery.

BCMs are a unique type of micelle, which releases the payload quickly when triggered by the acidic micro-environment of the tumor or when exposed to an intravenously administered chemical compound such as mannitol, an FDA-approved sugar compound often used as a diuretic agent, which interferes with the cross-linked micelles.

"This use of reversibly cross-linked targeting micellar nanocarriers to deliver anti-cancer drugs helps prevent premature drug release during circulation and ensures delivery of high concentrations of drugs to the tumor site," said first author Yuanpei Li, a postdoctoral fellow in Lam's laboratory who created the novel nanoparticle with Lam. "It holds great promise for a significant improvement in cancer therapy."

Stimuli-responsive nanoparticles are gaining considerable attention in the field of drug delivery due to their ability to transform in response to specific triggers. Among these nanoparticles, stimuli-responsive cross-linked micelles (SCMs) represent a vers
'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lower risk of death linked with access to key attributes of primary care, UC Davis study shows
2. $6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis
3. UC Davis researchers develop computer model for testing heart-disease drugs
4. UC Davis pain research may pave the way to understanding and controlling chronic pain
5. UC Davis surgeons test innovative device in patient with swallowing disorder
6. Inhaled steroids increase diabetes risk, say Lady Davis Institute researchers
7. UC Davis scientists find link between arthritis pain reliever and cardiovascular events
8. UC Davis study finds low liver cancer survival rates among Laotian/Hmong-Americans
9. New UC Davis study finds early Alzheimers identification method
10. DavisPTnetwork Recruits Bloggers to Report Key Session Learning Points Live from APTA 2010
11. DavisPTnetwork Partners with the Florida Physical Therapy Association to Provide Online Continuing Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 28, 2014 Nipomo Family Dentistry ... Do, recently opened its doors at 195 N. Thompson ... with preventative care like teeth cleanings, oral exams, fillings, ... Invisalign, teeth whitening (and Kor whitening), laser whitening, gum ... Nipomo Family Dentistry’s five-person team also takes a philanthropic ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 ... is lowering prices and offering savings in abundance ... hair care, hair loss and cosmetic products such ... and Bosley, TheBeautyPlace.com offers competitive discounts on already ... sold at affordable prices giving customers savings year ...
(Date:11/27/2014)... 2014 Ericdress.com today announced a ... up to 85% off, on all its clothing, shoes and ... Dec. 1 – 7, 2014 only. , At the special ... Orders above $109 can enjoy an extra $10 discount. Moreover, ... The business specially recommended its new collection of 2015 evening ...
(Date:11/27/2014)... knows, Cyber Monday is a crazy shopping day. Owing to ... now providing many big promotions on its website. Customers can ... current prices. The discount are up to 80% off. So ... orders above $88) from Dec. 1 – 4 2014. , ... are willing to shop on the internet. As a leading ...
(Date:11/27/2014)... Recently, DressVe , the well-known trendy young women’s clothing ... valid during Nov. 29 – Dec. 3 2014. In the ... up to 90% off. In addition, free delivery is provided ... http://www.dressve.com/ , Dresses that combine trendy styles and ... somebody’s personality and figure. The designers of DressVe.com know this ...
Breaking Medicine News(10 mins):Health News:Nipomo Family Dentistry Opens New Dental Office in Nipomo 2Health News:Nipomo Family Dentistry Opens New Dental Office in Nipomo 3Health News:TheBeautyPlace.com Announces Double Savings 2Health News:Ericdress.com Special Monday Sales Are Ready For Everyone 2Health News:Tidebuy.com Launching Overcoats Sales for the Special Monday in 2014 2Health News:DressVe.com Introduces Its 2014 Special Monday Sales To The Global Customers 2
... TUESDAY, Jan. 25 (HealthDay News) -- It,s hard to help ... long-term is even tougher. But obese children whose parents took ... weight and kept it off for the next two years, ... study shows that targeting parents -- rather than the children ...
... a friendly bartender can be the source of more than ... suggests that some bartenders may be in a good position ... help connect them to the appropriate agency. Researchers at ... Foreign Wars posts in Ohio. The results showed that ...
... Colo. (Jan. 25, 2011) A new study led ... at The Children,s Hospital and Colorado Health Outcomes Program ... explores the barriers, facilitators and alternative approaches to providers ... immunization registry. Reminder or recall messages, usually in the ...
... by further developing a culture of safety in which all ... can work together to maximize safety, according to an invited ... (PRO), a new medical journal whose mission is to ... official journal of the American Society for Radiation Oncology (ASTRO). ...
... 25 (HealthDay News) -- Epilepsy was the likely cause of ... to a new study. Researchers reached the conclusion that ... descriptions of his hallucinations -- including his description of a ... life written by pupils and friends such as George Sand. ...
... cardiovascular surgery, resulting in elevated circulating levels of cell-free ... and gut wall integrity is unclear. A research ... the World Journal of Gastroenterology addresses this ... levels similar to those found during cardiovascular surgery. The ...
Cached Medicine News:Health News:Changing Parental Behavior May Help Obese Kids Lose Weight 2Health News:Changing Parental Behavior May Help Obese Kids Lose Weight 3Health News:Bartenders may have role in assisting troubled war veterans 2Health News:Bartenders may have role in assisting troubled war veterans 3Health News:New study finds reminders for immunizations challenging for pediatric practices 2Health News:New study finds reminders for immunizations challenging for pediatric practices 3Health News:Culture of safety key to reducing chances for medical errors 2
(Date:11/26/2014)... CITY, Calif. , Nov. 26, 2014  Genomic ... Kim Popovits , Chairman, Chief Executive Officer and ... Piper Jaffray Healthcare Conference at The New York Palace ... Wednesday, December 3 at 11:30 am Eastern Time (ET). ... webcast of the conference call, go to the  Investor ...
(Date:11/26/2014)... , November 26, 2014 Investor-Edge has ... VVUS ), Horizon Pharma PLC (NASDAQ: HZNP ... Johnson (NYSE: JNJ ), and Theravance Inc. (NASDAQ: ... can be accessed at: http://investor-edge.com/register . On ... up 0.07%, the Dow Jones Industrial Average edged 0.02% lower, ...
(Date:11/26/2014)... , Nov. 26, 2014  CARsgen, a leader in ... immunotherapy to treat a variety of cancers, today announced ... BVCF, a China -based healthcare private ... company focused on the development of new therapeutics for ... Shanghai Cancer Institute and Shanghai Renji Hospital, the company ...
Breaking Medicine Technology:Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5CARsgen Completes Series A Financing 2
... 25, 2011 Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ... John H. Johnson as Chief Executive Officer, effective January 31, ... Savient,s board of directors. Mr. Johnson brings significant ... a Senior Vice President of Eli Lilly and Company and ...
... recently launched eCS Inpatient EHR V1.2 (eCS), the first ... medium hospitals. eCS,s uniqueness is the tight linkage of ... a single web-based software solution. The solution is offered ... simplified deployment. "eCS is an affordable solution ...
Cached Medicine Technology:Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 2Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 3Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 4eCareSoft Launches Comprehensive EHR for Small & Medium Hospitals 2
Transcranial vascular DWL doppler....
The Natural Selection family of specialty allografts is spinal concepts response to surgeon requests for spinal allograft devices to eliminate the need for painful autograft harvesting....
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
Medicine Products: