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UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
Date:11/27/2007

The UC Davis group also looked at a smaller number of cells during various stages of development, enabling them to more accurately dissect the different population subsets. The authors said that differences in cell culture and experimental conditions could also account for the results not seen in previous efforts.

According to Li, the fact that different cell lines exhibit different potentials for differentiation and maturation underscores the need to develop new and additional stem cell lines in order to advance critical research into potential therapies for patients.

This is a good example of the type of exciting, bench-to-bedside research now under way at UC Davis and the potential it has for new treatments, said Jan Nolta, director of the UC Davis Stem Cell Program in Sacramento As additional embryonic stem cell lines become available for research, well be able to more fully explore the possibilities inherent in this powerful field of bioscience.

Lis study is a first step toward deriving cardiomyocytes with fully functional contractile properties from human embryonic stem cells. With heart transplants being the current treatment of last resort due to severe shortages of donor organs and the complexity of transplantation, the long term goal of researchers like Li is to come up with alternatives that are both safe and effective.

Our latest study gives us great hope of eventually achieving a breakthrough where stem cell therapy could be used in the types of cases that today require a heart transplant, concluded Li.


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Contact: Charles Casey
charles.casey@ucdmc.ucdavis.edu
916-734-9048
University of California - Davis - Health System
Source:Eurekalert

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