Navigation Links
UC Davis researchers develop computer model for testing heart-disease drugs
Date:8/31/2011

(SACRAMENTO, Calif.) UC Davis researchers have developed an accurate computer model to test the effects of medications for arrhythmia, or abnormal heart rhythm, before they are used in patients.

The new tool -- described in the Aug. 31 issue of the journal Science Translational Medicine -- will help scientists screen anti-arrhythmia medications early in the drug-development pipeline and eventually guide physicians in prescribing those interventions to patients who could benefit the most.

"Drug development for arrhythmia has failed because it is difficult to anticipate how drugs will alter the heart's intricate electrical behavior prior to clinical trials," said Clancy, an associate professor of pharmacology at UC Davis and senior author of the study. "We developed a novel approach to solve this problem -- a computational framework for making early predictions about the effects of medications on cardiac rhythms."

In the 1980s, the Cardiac Arrhythmia Suppression Trial (CAST) study came to an abrupt halt when scientists discovered that the arrhythmia medication flecainide, used to treat abnormally fast heart rhythms, more than tripled the risk of sudden cardiac death compared to placebo in patients with irregular heartbeats.

"No one ever knew exactly why this happened, and we used our model to find out," said Clancy. "CAST gave us the clinical starting point for our study."

To further prove the model's utility, Clancy and her team also used it to test lidocaine, an anti-arrhythmia medication with a strong safety profile and sufficient clinical outcomes data.

In conducting the study, Clancy, a biophysicist who specializes in using high-performance computing to understand diseases arising from abnormal excitability, started with existing models that simulate the behavior of heart cells during both normal heart rhythms and arrhythmia. She then devised mathematical formulas to describe the interaction
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UC Davis pain research may pave the way to understanding and controlling chronic pain
2. UC Davis surgeons test innovative device in patient with swallowing disorder
3. Inhaled steroids increase diabetes risk, say Lady Davis Institute researchers
4. UC Davis scientists find link between arthritis pain reliever and cardiovascular events
5. UC Davis study finds low liver cancer survival rates among Laotian/Hmong-Americans
6. New UC Davis study finds early Alzheimers identification method
7. DavisPTnetwork Recruits Bloggers to Report Key Session Learning Points Live from APTA 2010
8. DavisPTnetwork Partners with the Florida Physical Therapy Association to Provide Online Continuing Education
9. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
10. Stanford researchers invent sutureless method for joining blood vessels
11. Yale researchers use genetic code to engineer a living protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... its top dressmaking technologies, has been a leading dress supplier ... latest designs of wedding dresses and launching a site-wide promotion ... the fresh new products are designed for 2015, and they ... All the clothes from LunaDress follow up with the latest ...
(Date:1/22/2015)... 2015 VogueQueen is a seasoned and trusted ... many designers are thrilled to have it lead the wedding ... new collection of prom dresses for the global market. , ... strategic vision and he focuses on continuing the goal of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of Cruz ... has treated just about every type of injury that can result ... those same twenty-plus years, the team at Doctors on Liens ... best possible doctor. With the combined breadth of experience ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
Breaking Medicine News(10 mins):Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Southwestern Medical Center maternal-fetal specialists have confirmed a potential ... risk for hepatitis B, a health problem that affects ... vaccination schedule for high-risk pregnant women was found effective ... Obstetrics & Gynecology . While the normal three-shot ...
... , MONDAY, June 27 (HealthDay News) -- Certain groups ... poorer outcomes and higher death rates than those treated ... study. Nearly five million people live in U.S. ... Northern Mariana Islands and the U.S. Virgin Islands, according ...
... childhood cancer survivors found that the first cancer is ... forms of the disease for about 10 percent of ... in the federally funded Childhood Cancer Survivor Study (CCSS). ... reported that 1,382, or 9.6 percent, of survivors developed ...
... 27 (HealthDay News) -- Uncovering some science behind the type ... and Canadian researchers reports that a woman can tell whether ... face when she is ovulating. Women also appear to ... they start to harbor romantic notions or mating aspirations, the ...
... Scientists have long known that, to form tissue structures ... the other cells, matrix, and signals in their environment. But ... to distinguish between normal and pathological behaviors. A team of ... to evaluate human stem cells using cell micropatterning a ...
... HealthDay Reporter , MONDAY, June 27 (HealthDay News) -- ... both by violent media content and greater evening use of ... Reviewing parent surveys and media diaries from 617 preschoolers, Seattle ... was linked to a significant jump in sleep problems, as ...
Cached Medicine News:Health News:Stepped-up vaccine series for hepatitis B is effective during pregnancy 2Health News:Childhood cancer survivors are at high risk for multiple tumors as they age 2Health News:Childhood cancer survivors are at high risk for multiple tumors as they age 3Health News:Does Ovulation Boost a Woman's 'Gaydar'? 2Health News:Tiny cell patterns reveal the progression of development and disease 2Health News:Tiny cell patterns reveal the progression of development and disease 3Health News:Content, Timing of TV Can Take Toll on Kids' Sleep 2Health News:Content, Timing of TV Can Take Toll on Kids' Sleep 3
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... , Jan. 22, 2015 Increasing sophistication among ... consolidation of localization purchasing in 2015, says Moravia ... to a recent study by market research firm Common ... single-source solution for their translation and localization needs. "From ...
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition ... & by End User - Global Forecast to 2019" ... diagnostics market is valued at $1,228.58 million in 2014 and ... reach $2,230.72 million by 2019. Allergy diagnostics is used to ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... Robbins & Myers, Inc. (NYSE: RBN ) ... second quarter ending February 28, 2010 , before the market ... is scheduled for Wednesday, March 24, 2010 , at ... Officer, and Christopher M. Hix , Vice President and Chief ...
... March 10 CVS Caremark Corporation (NYSE: CVS ) today announced that its Board of Directors has approved a quarterly dividend of $0.0875 per share on ... ... ... ...
Cached Medicine Technology:Robbins & Myers to Release Second Quarter Fiscal 2010 Financial Results 2CVS Caremark Corporation Announces Quarterly Dividend 2
... to support you in achieving improved ... the pressure to cut costs is ... resources and eliminate unnecessary manual interactions. ... with automatic control mechanisms like pipetting ...
Express Plus analyzer is a great choice for small and medium workloads....
... 1650 has minimal requirements for ... 2 L/test), reagent consumption (as ... water consumption (25 L/hour) - ... universal rack handler facilitates continuous ...
Iron FS Ferene for determination of iron in serum. Available with Calibrator: Trucal U and Controls: Trulab N, Trulab P. For automated systems....
Medicine Products: