Navigation Links
UC Davis Researchers Find How Viral Infection Disrupts Neural Development in Offspring, Increasing Risk of Autism
Date:9/19/2013

Sacramento, CA (PRWEB) September 19, 2013

Activating a mother’s immune system during her pregnancy disrupts the development of neural cells in the brain of her offspring and damages the cells' ability to transmit signals and communicate with one another, researchers with the UC Davis Center for Neuroscience and Department of Neurology have found. They said the finding suggests how maternal viral infection might increase the risk of having a child with autism spectrum disorder or schizophrenia.

The research, “MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease,” is published in the Journal of Neuroscience.

The study’s senior author is Kimberley McAllister, professor in the Center for Neuroscience with appointments in the departments of Neurology and Neurobiology, Physiology and Behavior, and a researcher with the UC Davis MIND Institute.

“This is the first evidence that neurons in the developing brain of newborn offspring are altered by maternal immune activation,” McAllister said. “Until now, very little has been known about how maternal immune activation leads to autism spectrum disorder and schizophrenia-like pathophysiology and behaviors in the offspring.”

The study was conducted in mice and rats and compared the brains of the offspring of rodents whose immune systems had been activated and those of animals whose immune systems had not been activated. The pups of animals that were exposed to viral infection had much higher brain levels of immune molecules known as the major histocompatibility complex I (MHCI) molecules.

“This is the first evidence that MHCI levels on the surface of young cortical neurons in offspring are altered by maternal immune activation,” McAllister said.

The researchers found that the high MHCI levels impaired the ability of the neurons from the newborn mice’s brains to form synapses, t
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Novel Vaccine Approach to Human Cytomegalovirus Found Effective Says UC Davis Study
2. UC Davis study applies timely cost-effectiveness analysis to state breast cancer screening program
3. CareClix Provides Telemedicine Services to Leading Provider of Warehouse and Shipping Services, Davis Storage of Danville, Virginia
4. UC Davis Children's Hospital Saves the Life of 14-year-old Bishop, Calif. Teen Infected with Hantavirus
5. UC Davis Study Identifies Better Blood Glucose Monitor for Burn Care
6. UC Davis Team "Spikes" Stem Cells to Generate Myelin
7. UC Davis Develops New Strategy Tests for Dangerous Stage of Tuberculosis in Asia
8. UC Davis Children's Hospital Study Finds Telemedicine Consultations Significantly Improve Pediatric Care in Rural Emergency Rooms
9. UC Davis "Lab on a Chip" Measures Heart Disease Risk
10. Davis Hospital and Medical Center is First Hospital in Utah to Offer New CelluTome™ System for Skin Grafting
11. Actors, Models & Talent for Christ Grad, Charles Michael Davis, Stars in Grey’s Anatomy, Another Stateside (post-production), and New TV Series The Originals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... Global Vision , the world ... be spotlighting its award-winning print and artwork inspection solutions, ScanProof and ArtProof ... 17 at the Olympia London, booth #F33 , Be the first to get a ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... data collection, cloud analytics and workflow solutions today announced the complete faculty ... September 22-24, 2015. The esteemed faculty of worldwide pharmaceutical and industry experts ...
(Date:9/3/2015)... ... September 03, 2015 , ... “Love in Tokyo” an ... Google Play , and Amazon and will be released on DVD early ... Darling is a Foreigner,” Itsuka, an actress and singer/songwriter, and Jason London, lead from ...
(Date:9/3/2015)... ... ... types of people who have a hard time gaining weight , it seems that ... those that have a fast metabolism. In order to help those people who have a ... slowing down metabolism. , The first thing to do is to space out meals. When ...
(Date:9/3/2015)... ... September 03, 2015 , ... Doctor Kayode Sotonwa can be counted on ... His perspective on internal medicine keeps patients happy and healthy, something that is important ... of the season, but even more so in the fall, when holiday eating and ...
Breaking Medicine News(10 mins):Health News:Global Vision to Spotlight Intelligent Proofreading at Packaging Innovations 2015 2Health News:Global Vision to Spotlight Intelligent Proofreading at Packaging Innovations 2015 3Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 2Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 3Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 3Health News:Doctor Kayode Sotonwa Highlights Expert Tips for Staying in Shape This Fall 2
... Access to Basic,Care plan could help thousands of ... of Community and Economic Development,Secretary Dennis Yablonsky said ... "The vast majority of Pennsylvania,s uninsured adults ... businesses that struggle to make a,profit," said Yablonsky. ...
... D,ALENE, Idaho, May 23 NightHawk,Radiology Holdings, Inc. ... radiology,solutions to radiology groups and hospitals throughout the ... the Goldman Sachs 29th Annual,Global Healthcare Conference in ... at,8:40 am PDT. Presenting at the conference will ...
... also lower cholesterol, study says , , FRIDAY, May ... in antioxidants and may help protect against liver damage, ... The berries of the plant -- indigenous to the ... well known for their high levels of antioxidants and ...
... Linkwell,Corporation (Linkwell) (OTC Bulletin Board: LWLL), a ... disinfectants in China,announced today that it was ... relief efforts. The Chinese government, non-government,organizations (NGOs) ... scale in response to the earthquake in ...
... John G. Rangos Sr. Research Center at Childrens Hospital ... for the development of new therapies to treat hypertriglyceridemia, ... obese and diabetic. Results of their study are published ... Investigation. , Scientists in the Division of Immunogenetics at ...
... make a world of difference for Singer Songwriter Katie ... Reider Beginning May 23, ... songwriter Katie Reider, age 29, has inspired the hearts of,thousands with ... across the country are banding together to help Katie,during her ongoing ...
Cached Medicine News:Health News:PA ABC Will Benefit Commonwealth's Small Businesses, DCED Secretary Says 2Health News:NightHawk Radiology Holdings, Inc. to Speak at the Goldman Sachs 29th Annual Global Healthcare Conference 2Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 2Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 3Health News:Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides 2Health News:Katie Reider - Listen to Her Songs, Hear Her Story, Log Onto www.500kin365.org 2Health News:Katie Reider - Listen to Her Songs, Hear Her Story, Log Onto www.500kin365.org 3
(Date:9/2/2015)... quantum dot market report analyzes the ecosystem of the quantum ... includes medical devices, display, and others. The others segment consists ... QD laser, and transistor. The application segment covers the market ... report also provides the geographic view for major regions like ... , Asia-Pacific (APAC), and Rest ...
(Date:9/2/2015)... Colo. , Sept. 2, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in Boston.  The public is welcome ... on the Array BioPharma website.Event: Wells Fargo Securities ... Thursday, September 10, 2015Time:  , 10:20 a.m. Eastern ...
(Date:9/2/2015)... STAAR Surgical Company (NASDAQ: STAA ), a ... systems for the eye, today announced that its Board of ... Company,s Board. Mr. Wall was formerly the ... -based investment firm, for more than nine years. Mr. Wall ... chair of the Corporate Governance Committee and member of the ...
Breaking Medicine Technology:Quantum Dot Market by Product , Material, Application, and Geography- Forecast up to 2020 2William P. Wall Appointed to STAAR Surgical Board of Directors 2
... 17, 2012  Tengion, Inc. (NASDAQ: TNGN ), ... recently completed a successful Pre-IND meeting with the U.S. ... program, the Neo-Kidney Augment™. The FDA and the Company ... study program required to support an Investigational New Drug ...
... Ventures, Inc. (OTCBB: SNPK) (PINKSHEETS: SNPK) (the "Company" ... Distribution Specialists, LLC ("HDS") are pleased to announce that ... and Hemostasis Summit of North America (the "THSNA") to ... Chicago.  "Participation as an official exhibitor ...
Cached Medicine Technology:Tengion Announces IND Filing for Neo-Kidney Augment Expected During First Half of 2013 2Tengion Announces IND Filing for Neo-Kidney Augment Expected During First Half of 2013 3Tengion Announces IND Filing for Neo-Kidney Augment Expected During First Half of 2013 4Tengion Announces IND Filing for Neo-Kidney Augment Expected During First Half of 2013 5Sunpeaks Ventures to Exhibit Clotamin at the first-ever Thrombosis and Hemostasis Summit of North America 2
... tray is specifically designed for a variety ... x 13.34cm dot blot transfer membranes. The ... a standard microplate for compatibility with various ... available dot blot membranes without trimming., With ...
Mini Trans-Blot and PowerPac 300 System, 110-120 V...
... The GENIE is the proven electrophoretic transfer apparatus ... field uniformity. Its design allows for a very ... with a low voltage power source such as ... volts/cm. The result is exceptionally rapid and exact ...
... transfer apparatus incorporating state-of-the-art plate electrodes for the ... a very close positioning of the electrodes which, ... such as a battery charger, creates a high ... and exact electrophoretic transfer. ...
Medicine Products: