Navigation Links
UC Davis Researchers Find How Viral Infection Disrupts Neural Development in Offspring, Increasing Risk of Autism
Date:9/19/2013

Sacramento, CA (PRWEB) September 19, 2013

Activating a mother’s immune system during her pregnancy disrupts the development of neural cells in the brain of her offspring and damages the cells' ability to transmit signals and communicate with one another, researchers with the UC Davis Center for Neuroscience and Department of Neurology have found. They said the finding suggests how maternal viral infection might increase the risk of having a child with autism spectrum disorder or schizophrenia.

The research, “MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease,” is published in the Journal of Neuroscience.

The study’s senior author is Kimberley McAllister, professor in the Center for Neuroscience with appointments in the departments of Neurology and Neurobiology, Physiology and Behavior, and a researcher with the UC Davis MIND Institute.

“This is the first evidence that neurons in the developing brain of newborn offspring are altered by maternal immune activation,” McAllister said. “Until now, very little has been known about how maternal immune activation leads to autism spectrum disorder and schizophrenia-like pathophysiology and behaviors in the offspring.”

The study was conducted in mice and rats and compared the brains of the offspring of rodents whose immune systems had been activated and those of animals whose immune systems had not been activated. The pups of animals that were exposed to viral infection had much higher brain levels of immune molecules known as the major histocompatibility complex I (MHCI) molecules.

“This is the first evidence that MHCI levels on the surface of young cortical neurons in offspring are altered by maternal immune activation,” McAllister said.

The researchers found that the high MHCI levels impaired the ability of the neurons from the newborn mice’s brains to form synapses, t
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Novel Vaccine Approach to Human Cytomegalovirus Found Effective Says UC Davis Study
2. UC Davis study applies timely cost-effectiveness analysis to state breast cancer screening program
3. CareClix Provides Telemedicine Services to Leading Provider of Warehouse and Shipping Services, Davis Storage of Danville, Virginia
4. UC Davis Children's Hospital Saves the Life of 14-year-old Bishop, Calif. Teen Infected with Hantavirus
5. UC Davis Study Identifies Better Blood Glucose Monitor for Burn Care
6. UC Davis Team "Spikes" Stem Cells to Generate Myelin
7. UC Davis Develops New Strategy Tests for Dangerous Stage of Tuberculosis in Asia
8. UC Davis Children's Hospital Study Finds Telemedicine Consultations Significantly Improve Pediatric Care in Rural Emergency Rooms
9. UC Davis "Lab on a Chip" Measures Heart Disease Risk
10. Davis Hospital and Medical Center is First Hospital in Utah to Offer New CelluTome™ System for Skin Grafting
11. Actors, Models & Talent for Christ Grad, Charles Michael Davis, Stars in Grey’s Anatomy, Another Stateside (post-production), and New TV Series The Originals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 Hands On Mobile Spa, has announced ... Spa On Wheels has been transformed into a utopia for ... world seems to disappear. The Virtual Tour showcases the beauty ... parties, corporate events and more. , The Virtual Tour shows ... which is actually an overhauled Winnebago. Marla Kaplan-Pelle, Director states ...
(Date:12/19/2014)... 19, 2014 Slone Partners ... personalized medicine, healthcare information technology, and laboratory testing ... of Chief Operating Officer. The announcement comes after ... by a strengthened presence in Boston and several ... lives and breathes the client experience," said Adam ...
(Date:12/19/2014)... Wilmington, VT (PRWEB) December 19, 2014 ... full-service private ski club in Southern Vermont’s Deerfield Valley, ... trail names inspired by classic rock songs. , ... the weekend with a private concert followed by a ... said, “The new trail names include: “I’m Alright” the ...
(Date:12/19/2014)... Amy Norton HealthDay Reporter ... to moms who were exposed to high levels of air ... developing autism, a U.S. study suggests. Researchers found that ... and 2002, those exposed to the most air pollution during ... later developed autism. And exposure during the third trimester, specifically, ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, ... leg for at least 20 seconds you may be at ... on one leg may indicate that small strokes or tiny ... serious strokes is high, the investigators reported online Dec. 18 ... while standing on one leg, as well as problems walking, ...
Breaking Medicine News(10 mins):Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 2Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 3Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:The Hermitage Club Officially Names Four Ski Trails after Iconic Rock Songs by Grammy Award Winner Kenny Loggins 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3Health News:Can You Balance on One Leg? You May Have Lower Stroke Risk 2
... , THURSDAY, May 3 (HealthDay News) -- New ... a significant role in a major advance in human brain ... SRGAP2 gene has been duplicated at least twice during human ... 2.5 million years ago. The second duplication produced only a ...
... Being cut off from work email significantly reduces stress and ... study by UC Irvine and U.S. Army researchers. Heart ... office setting, while software sensors detected how often they switched ... and were in a steady "high alert" state, with more ...
... Brophy Marcus HealthDay Reporter , THURSDAY, May ... to plague people with celiac disease than those without ... the digestive tract and the brain has been studied ... researchers have linked celiac disease and other bowel problems ...
... health research programs are collaborating with community groups to ... informed consent, collect data and provide input on study ... researchers, community groups and institutional review boards about research ... that have a role in community-engaged research," according to ...
... News) -- Despite the fact that Americans spend more on ... a new report finds that more does not necessarily equal ... Commonwealth Fund report, led by senior research associate David Squires, ... per capita for health care, according to 2009 figures. By ...
... protein complex involved in the spatial organization of the ... have two versions of cohesin that contain either SA1 ... ignored. Researchers of the Spanish National Cancer Research Centre ... new functions of cohesin SA1 that are relevant for ...
Cached Medicine News:Health News:New Clues to the Evolution of the Human Brain 2Health News:Email 'vacations' decrease stress, increase concentration, researchers say 2Health News:Migraines More Likely for People With Celiac Disease, Study Says 2Health News:Migraines More Likely for People With Celiac Disease, Study Says 3Health News:Better ethics education needed in community-based research 2Health News:U.S. Health Care Spending High, But Quality Lags: Report 2Health News:U.S. Health Care Spending High, But Quality Lags: Report 3Health News:CNIO researchers describe new functions of cohesin relevant for human disease 2
(Date:12/19/2014)... , Dec. 18, 2014 Baptist Health Lexington is ... to receive full Atrial Fibrillation with Electrophysiology Services (EPS) ... Atrial fibrillation is the most common cardiac arrhythmia ... some cases can lead to stroke and possible death. More ... have atrial fibrillation and the numbers are rapidly ...
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, 2014 ... ; AEX: PHIA) and Volcano Corporation (NASDAQ: VOLC ... for cardiovascular applications, today announced that they have entered into ... commence a tender offer to acquire all of the issued ... or a total equity purchase price of USD 1 billion ...
(Date:12/17/2014)... With advancements in neurological and functional ... seeing new growth, according to Kalorama Information. Though ... the majority of market volume, newer 3T systems ... are creating opportunities for more sophisticated applications. The medical ... a rate of 4%, with world market revenues ...
Breaking Medicine Technology:Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3
... Chrono-log's wide range of Platelet ... capabilities to meet particular needs. Single, ... available, with chart recorder outputs or ... the Chrono-log Optical aggregometers, which measure ...
... PAP-4 is a four channel Platelet Aggregation ... von willebrand assay (Ristocetin cofactor), platelet aggregation ... be used for the evaluation and confirmation ... allow four tests to be run simultaneously ...
... PAP-4D is a four channel Platelet Aggregation ... system. Operating in conjunction with Microsoft Windows, ... display of tests, automatic storage of test ... management. Three test modes are available: von ...
... in achieving improved cost efficiency in ... cut costs is constantly increasing. Optimize ... unnecessary manual interactions. Ensuring security of ... mechanisms like pipetting integrity check. Right ...
Medicine Products: