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UC Davis "Lab on a Chip" Measures Heart Disease Risk
Date:8/6/2013

actually experienced a cardiac event — interact with this model of the artery wall,” said Armstrong. “We are coming close to observing atherosclerosis in action at a personal level.”

The lab-on-a-chip may one day be used to provide a rapid risk assessment tool that could be used in doctors’ offices. It may also be useful as a tool for further research in therapeutics.

“Interventions that target monocyte activation could reduce progression of atherosclerosis. In patients who have already had a heart attack, it is possible that such interventions could also reduce long-term injury to the heart,” said Armstrong.

The interdisciplinary team plans to carry the investigations further to refine their understanding of the cellular mechanisms of atherosclerosis. They would also like to conduct studies on larger populations over long time periods to better determine the predictive utility of the test.

The study, titled “On-Chip Phenotypic Analysis of Inflammatory Monocytes in Atherogenesis and Myocardial Infarction,” is available online at http://www.pnas.org/content/early/2013/08/02/1300651110 or by contacting the journal at PNASnews(at)nas(dot)edu or 202-334-1310.

Funding for the study was provided by the National Heart, Lung, and Blood Institute and with a Clinical Research Program Award from the American Heart Association.

Other study authors, all from UC Davis, are Greg Foster and Robert Michael Gower of the Department of Biomedical Engineering, and Kimber Stanhope and Peter Havel of the Department of Nutrition and Department of Molecular Biosciences, School of Veterinary Medicine.

About UC Davis
For more than 100 years, UC Davis has engaged in teaching, research and public service that matter to California and transform the world. Located close to the state capital, UC Davis has more than 33,000 studen
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