Navigation Links
UC Davis "Lab on a Chip" Measures Heart Disease Risk
Date:8/6/2013

them easily adhere to endothelial cells that line the inner surfaces of blood vessels and promoting plaques that clog arteries and lead to cardiac events.

The team used the “lab on a chip” to study the blood of 35 volunteers with varied levels of baseline triglycerides but who were otherwise healthy, along with the blood of 18 volunteers who each had experienced a heart attack. The small device — only a few square inches in area — forces blood to flow at a speed similar to blood in arteries over a specially treated glass slide that serves as a molecular substrate that models artery walls. The blood is then analyzed using a microscope that detects the relative levels of CD14++, CD16+ and integrins that stick to the substrate.

“Our lab-on-a-chip is unique in that it mimics the conditions in an actual artery during the early stages of atherosclerosis,” said Simon, who developed the technology used in the study.

After eating a high-fat meal to induce an inflammatory state, the blood of the healthy volunteers with varying triglyceride levels revealed that the monocytes had adhered to the chip substrate with sevenfold higher efficiency than other cells, proving that they are accurate biomarkers of inflammation. Further investigation showed that the increased monocyte adhesion was due to increased expression of a specific integrin known as CD11c, which was upregulated after the high-fat meal.

The evaluation of blood samples from patients who had experienced a heart attack showed that levels of CD14++ and CD16+ monocyte adhesion due to the integrin CD11c increased by 100 percent when compared to levels of these cells in the blood of healthy volunteers, indicating that these biomarkers increased proportionate to the level of cardiac disease.

“We can actually see how monocytes in the blood of people with different risks for atherosclerosis and heart attack — ranging from people with low to high triglyceride levels to those who had
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Dr. Davis Announces Some Diagnoses of ADHD May be Misinterpreted Visual Problems: Could Be Treated with Vision Therapy
2. UC Davis study finds stray-bullet shootings frequently harm women and children
3. UC Davis scientists identify new target for lung cancer treatment
4. UC Davis study shows that treadmill testing can predict heart disease in women
5. UC Davis study links low wages with hypertension, especially for women and younger workers
6. Gun retailers take a hard line on illegal firearm sales, UC Davis survey finds
7. UC Davis research advances efforts to prevent dangerous blood clots
8. UC Davis MIND Institute receives prestigious Autism Centers of Excellence Award
9. Consolidated Facility Advises Spring Cleaning Done Now in Davis Businesses
10. Actors, Models & Talent for Christ Graduate, Charles Michael Davis in Grey’s Anatomy and Big Screen Movie Another Stateside
11. Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... repaired knee Anterior Cruciate Ligament (ACL) happens all too ... the American Orthopaedic Society for Sports Medicine,s (AOSSM) Annual ... risk factors may minimize the chance of a future ... few risk factors such as, age, activity level and ... of re-injury," said lead author, Christopher C. Kaeding, MD ...
(Date:7/11/2014)... July 11, 2014 With the maturity ... requirements on comfort, the installation rate of Chinese car ... the installation rate exceeded 88% and the demand outnumbered ... the next few years, Chinese car electric window regulator ... 2017, the market size is expected to exceed 110 ...
(Date:7/11/2014)... Wild by Nature, a natural and organic supermarket ... opening a fifth store to be located in West Islip, ... the largest selections of wheat and gluten-free products available. With ... stores have become a one-stop shop for anyone who needs ... gluten intolerance, is a spectrum of disorders, including celiac disease, ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 B. E. Smith, ... providers, has been retained to lead a national chief ... in Bend, Ore. The top executive search firm ... placed more than 900 healthcare executives into organizations. , ... St. Charles Health System is the largest provider of medical ...
(Date:7/11/2014)... the experienced dressmaker in the world, has become one ... to beach wedding dresses . Recently, the firm ... in its online shop. Included in the new range ... has been considered as one of the best garment ... spokesman, BellasDress provides superb special occasion gowns and great ...
Breaking Medicine News(10 mins):Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 2Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 3Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 4Health News:Wild by Nature Opens New Location 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 3Health News:BellasDress Emerges As Popular Online Supplier Of 2014 Beach Wedding Dresses 2
... to treat kidney cancer also targets a genetic mutation active ... (AML), the most common and lethal form of adult leukemia, ... Center report in the Jan. 29 edition of the Journal ... clinical trial, the drug sorafenib reduced the median percentage of ...
... Enforce PROTONIX Patent -, MADISON, N.J., Jan. 29 ... Nycomed, today announced the U.S. launch of Wyeth,s,own generic ... of generic pantoprazole tablets in the U.S. by Teva ... version of PROTONIX,will be distributed by Prasco starting today., ...
... Funding for Bioscience Summer Internship Program Over ... ... Foundation today,awarded $6.5 million to the Translational Genomics Research Institute,(TGen) as ... TGen for the next 25 years. The program helps cultivate new,scientific ...
... 29 At an Election Day,candidate forum in Tampa, ... Mitt Romney told a crowd of the,organization,s conservative seniors ... Hillarycare is not the answer., "I am convinced ... issue and,get our citizens insured but do it in ...
... Nektar,Therapeutics, (Nasdaq: NKTR ) President and Chief ... the upcoming Merrill Lynch,Pharmaceutical, Biotechnology & Medical Device Conference ... on Tuesday, February 5, 2008 at 1:00 p.m.,ET., ... a live,audio-only Webcast through a link posted on the ...
... Zimmer Holdings, Inc.,(NYSE: ZMH ; SWX: ... it will be participating in Merrill Lynch,s 19th ... New York on,February 5, 2008, at 8:00 a.m. ... presentation can be accessed via Zimmer,s,Investor Relations website ...
Cached Medicine News:Health News:Kidney cancer drug attacks a major type of acute myeloid leukemia 2Health News:Kidney cancer drug attacks a major type of acute myeloid leukemia 3Health News:Wyeth Announces Launch of Own Generic Version of PROTONIX 2Health News:Wyeth Announces Launch of Own Generic Version of PROTONIX 3Health News:Helios Education Foundation Invests $6.5 Million in New Partnership with TGen 2Health News:Helios Education Foundation Invests $6.5 Million in New Partnership with TGen 3Health News:Helios Education Foundation Invests $6.5 Million in New Partnership with TGen 4
(Date:7/10/2014)... July 10, 2014  Breg, Inc., a premier ... launched the FreeRunner™ knee brace with new innovations ... patella mal-tracking return to active lifestyles.  FreeRunner,s patent-pending ... braces, providing support when patients need it most, ... don,t. Patellofemoral issues are the most ...
(Date:7/10/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... completed the sale to Galderma of all rights to ... by Valeant for $1.4 billion in cash, pursuant to ... completed its acquisition of Galderma. "We ... to a company that is firmly committed to the ...
(Date:7/10/2014)... Mass. , July 10, 2014 Decision ... report awareness of the U.S. Food and Drug Administration,s ... new phosphate binder Velphoro, which was approved by the ... in chronic kidney disease (CKD) patients on dialysis. ... TreatmentTrends: Nephrology (US) Q2 2014 : ...
Breaking Medicine Technology:Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... The Medical Oncology Association of Southern California ... an agreement to work together to expand use ... costs of cancer care in Southern California. ... and distribution services to help health care professionals, ...
... The American Society of Bariatric Physicians (ASBP) is sad ... go out to his family, friends and fans.  The recent ... a contributing factor to his death are concerning and bring ... prescribed. While the specific details of Bubba ...
Cached Medicine Technology:Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 2Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 3Physicians Who Treat Obesity Respond to the News of Bubba Smith's Overdose 2
BD Beaver Cataract blade, 30.0 mm long x 2.2 mm wide, designed for ICCE and ECCE procedures, designed for ICCE and ECCE, sterile....
BD Beaver Chondroplastic blade, sharp on two sides, curved, sterile...
BD Beaver Meniscus blade, 7 mm flat (4/bx, 1 bx/ca), specially designed maximum leverage and visibility, cutting edge: 7 mm, sterile....
... accurate testing of large oculomotor ... Fits all standard trial frames. ... of thin optical quality acrylic ... includes a display box. Available ...
Medicine Products: