Navigation Links
UC Davis "Lab on a Chip" Measures Heart Disease Risk
Date:8/6/2013

them easily adhere to endothelial cells that line the inner surfaces of blood vessels and promoting plaques that clog arteries and lead to cardiac events.

The team used the “lab on a chip” to study the blood of 35 volunteers with varied levels of baseline triglycerides but who were otherwise healthy, along with the blood of 18 volunteers who each had experienced a heart attack. The small device — only a few square inches in area — forces blood to flow at a speed similar to blood in arteries over a specially treated glass slide that serves as a molecular substrate that models artery walls. The blood is then analyzed using a microscope that detects the relative levels of CD14++, CD16+ and integrins that stick to the substrate.

“Our lab-on-a-chip is unique in that it mimics the conditions in an actual artery during the early stages of atherosclerosis,” said Simon, who developed the technology used in the study.

After eating a high-fat meal to induce an inflammatory state, the blood of the healthy volunteers with varying triglyceride levels revealed that the monocytes had adhered to the chip substrate with sevenfold higher efficiency than other cells, proving that they are accurate biomarkers of inflammation. Further investigation showed that the increased monocyte adhesion was due to increased expression of a specific integrin known as CD11c, which was upregulated after the high-fat meal.

The evaluation of blood samples from patients who had experienced a heart attack showed that levels of CD14++ and CD16+ monocyte adhesion due to the integrin CD11c increased by 100 percent when compared to levels of these cells in the blood of healthy volunteers, indicating that these biomarkers increased proportionate to the level of cardiac disease.

“We can actually see how monocytes in the blood of people with different risks for atherosclerosis and heart attack — ranging from people with low to high triglyceride levels to those who had
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Dr. Davis Announces Some Diagnoses of ADHD May be Misinterpreted Visual Problems: Could Be Treated with Vision Therapy
2. UC Davis study finds stray-bullet shootings frequently harm women and children
3. UC Davis scientists identify new target for lung cancer treatment
4. UC Davis study shows that treadmill testing can predict heart disease in women
5. UC Davis study links low wages with hypertension, especially for women and younger workers
6. Gun retailers take a hard line on illegal firearm sales, UC Davis survey finds
7. UC Davis research advances efforts to prevent dangerous blood clots
8. UC Davis MIND Institute receives prestigious Autism Centers of Excellence Award
9. Consolidated Facility Advises Spring Cleaning Done Now in Davis Businesses
10. Actors, Models & Talent for Christ Graduate, Charles Michael Davis in Grey’s Anatomy and Big Screen Movie Another Stateside
11. Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... 2015 Carinsurancequotesinfo.com has released a new ... cost auto insurance for flatbed trucks. , ... sometimes other vehicles. They are mainly used for commercial ... released blog post explains that by comparing multiple offers, ... and other commercial vehicles. , It is now possible ...
(Date:4/25/2015)... Islands, BWI (PRWEB) April 25, 2015 ... has celebrated three months of successfully welcoming visitors to ... 5, 2015. , As part of a major ... Providenciales airport was completely redesigned to speed up arrivals. ... the process of getting out of the airport and ...
(Date:4/25/2015)... York New York (PRWEB) April 25, 2015 ... that Dr. Jerry Blaivas has been chosen by the New ... for his contributions to medicine in the field of Urology. ... the best in his speciality, Genito-Urinary diseases. He was ... specifically in the field of urology. Not only did ...
(Date:4/25/2015)... 2015 For thirteen years, the Twin Cities ... education event in the nation! This year, on May 5th, ... US to take DI Day on the road by supporting ... CLU, ChFC, RHU, DIA, CLTC, Chief Executive Officer at Secura ... on the change by stating, "The first Twin Cities DI ...
(Date:4/24/2015)... 24, 2015 Multi Customer Discount , ... pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 gallons in Zeiter's ... program. This does not include any Dig fees, or ... per person. If someone is part of this group ... totaling approximately 2500 gallons or more, the cost would ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Secura Consultants Takes DI Day On The Road 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3
... Qiao Xing,Mobile Communication Co., Ltd. (,Qiao Xing Mobile, or ... domestic manufacturers of mobile,handsets through its subsidiary CEC Telecom ... C7000A cardiograph mobile handset., The C7000A has ... will be able to perform a basic ...
... form of breast cancer are being tested in a ... six continents -- a clinical trial that investigators hope ... This trial, dubbed ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment ... initiatives in which two large, academic breast cancer research ...
... affected by ... rare diseases, NEW YORK, Feb. ... Day will be launched on Friday 29,February...because it,s a rare day that ... Shire plc at:, http://media.medialink.com/WebNR.aspx?story=34701 ), Collectively, rare diseases aren,t ...
... Firm,s Growing Healthcare Practice, BROOKFIELD, Wis., Feb. ... human resources outsourcing company, has added,Gordon Warner to ... Services,Director., Warner brings extensive HR experience and ... Warner comes to Pinstripe from,M&I Bank in Milwaukee, ...
... 28 Millennium,Pharmaceuticals, Inc. (Nasdaq: MLNM ... 2008 Susquehanna Healthcare Conference will be webcast ... Investors section of the Company,s website, http://www.millennium.com ... The presentation will include an overview ...
... Idaho, Feb. 28 NightHawk,Radiology Holdings, Inc. (Nasdaq: ... groups across the United States, today announced,that Ernest G. ... of the,company,s Board of Directors for personal reasons. Mr. ... company intends to immediately begin a search,to identify a ...
Cached Medicine News:Health News:Qiao Xing Mobile's CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0'' LCD Screen 2Health News:Qiao Xing Mobile's CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0'' LCD Screen 3Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 2Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 3Health News:New study of targeted therapies for breast cancer -- model for global clinical trials 4Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 2Health News:VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda 3Health News:Pinstripe Healthcare Group Adds Veteran HR Executive Warner as Client Services Director 2Health News:2008 Susquehanna Healthcare Conference to Webcast Millennium Presentation 2Health News:NightHawk Radiology Holdings, Inc. Announces Board Member Departure 2
(Date:4/24/2015)... 2015 Research and Markets ... of the "Lab Accessories Market by ... Station) & End User (OEM/Biotechnology & Pharmaceutical ... 2020" report to their offering. ... expected to reach $504.7 million by 2020 ...
(Date:4/24/2015)... Company, Inc. (NYSE: LCI ) today announced that ... facility to $120 million from $50 million.  The amended ... company to increase borrowings by a total of up ... commitments from existing lenders or new lending institutions.  The ... 2018.   "The amended credit facility, together ...
(Date:4/23/2015)... CHICAGO, Ill. , April 24, 2015  AbbVie ... Food and Drug Administration (FDA) has accepted its New ... company,s, all-oral, interferon-free, two direct-acting antiviral treatment of ombitasvir, ... for the treatment of adults with chronic genotype 4 ... regimen is the first all-oral, interferon-free therapy being evaluated ...
Breaking Medicine Technology:Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3Lannett Expands Revolving Credit Facility To $120 Million 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7
... compact Allegra X-22 Series is up to 10 inches/ ... library of 11 rotors, the Allegra X-22 Series is ... Features: Only 18 inches / 46 cm wide ... x g 3 different ways to Spin 1.5 ...
... Fractionation, Proteins and Viruses • ... with fixed-angle rotor • Spin ... 85 mL • Operating temperature ... C • Rotors certified by ...
... Eppendorf Multipurpose Centrifuges feature ... accommodate a variety of rotors ... are three centrifuges in one: ... centrifuge for cell harvesting; a ...
... MicroCentrifuge 6-Place Rotor has a standard 1.5ml rotor ... .4ml adapters. Easy operation (no switches to mess ... and press the plastic tab to open. Starts ... rpm and 2000 x g. Only five inches ...
Medicine Products: