Navigation Links
UBC scientists find new way to mobilize immune system against viruses
Date:5/12/2014

University of British Columbia scientists have uncovered an intricate chain reaction in the body's immune system and have used the knowledge to develop a new treatment against harmful viruses.

Viral pandemics, such as the coronavirus that caused the deadly SARS outbreak in 2002, have caused hundreds of deaths in Canada, yet effective anti-viral drugs are rare.

A key element to this natural immune response is an antiviral protein in the blood called Interferon alpha. Like soldiers, Interferon alpha is quickly deployed by the body to fight viruses and removed just as quickly to restore equilibrium.

As described in the current issue of the prestigious journal Nature Medicine, a team led by Overall from UBC's Department of Oral Biological and Medical Sciences and Bruce McManus from UBC's Department of Pathology and Laboratory Medicine has discovered that an enzyme called MMP12 serves double-duty in the deployment of the critical antiviral protein: it first enters the infected cell to activate Interferon alpha and then sends it outside the cell membrane to fight viruses. After the job of Interferon alpha is done, MMP12 dissolves the protein during the healing process.

Overall has developed a new antiviral drug that blocks MMP12 from dissolving Interferon alpha outside the cell, giving the immune system an added boost by keeping levels of the protein high in the bloodstream. The drug cannot penetrate cell membranes, making it unable to interfere with the beneficial work inside the cell. The drug has been shown to effectively treat viral infections in mice models and holds promise as a new broad-spectrum antiviral treatment.

"Because the drug isn't virus-strain specific and boosts the body's own immune response to fight infections, it could be effective for even emergent, unknown viruses and eliminate the lag time required to first identify and sequence the virus genetic material before we can treat it," says Overall.


'/>"/>

Contact: Dr. Chris Overall
chris.overall@ubc.ca
604-808-3587
University of British Columbia
Source:Eurekalert

Related medicine news :

1. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
2. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
3. Scientists identify new protein in the neurological disorder dystonia
4. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
5. Norwegian neuroscientists elected to National Academy of Sciences
6. NIH scientists establish monkey model of hantavirus disease
7. Stanford scientists create circuit board modeled on the human brain
8. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
9. Scientists find way to target cells resistant to chemo
10. Scientists identify cancer specific cell for potential treatment of gastric cancer
11. Scientists pinpoint protein that could improve small cell lung cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... Ventura, CA (PRWEB) , ... May 04, 2016 , ... ... cutting-edge technology to help restore its patients’ health, is hosting a free seminar on ... and will be held at Advanced Spine & Sport, 4601 Telephone Road, Suite 110, ...
(Date:5/4/2016)... , ... May 04, 2016 ... ... compression and support for knees, ankles, and elbows. Engineered with athletes in ... 3D flat-bed manufacturing (opposed to ineffective circular knitting, common in the industry) ...
(Date:5/4/2016)... ... May 03, 2016 – (PRWEB) May ... and child products, today revealed the non-toxic benefits of its Tutti ... deal with teething pain is just part of the story. These ... are BPA-, PVC-, and phthalate-free. , “Many baby toys contain ...
(Date:5/4/2016)... ... May 04, 2016 , ... With the stamp of approval from the United ... as National Cancer Research Month. According to the American Cancer Society (2016) , ... of one in four Americans dying as a result. , With numbers as influential ...
(Date:5/4/2016)... ... May 04, 2016 , ... Over 40 athletic trainer’s (ATs) and ... capitol for the annual “Hike to Harrisburg” advocacy day. The annual lobbying effort ... PATS lobby Group. The goal for the day was to educate the elected ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016  It,s time for an upgrade. There are many medical ... brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and functionality.  ... as a world class manufacturer of innovative technology.  Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
(Date:5/4/2016)... May 4, 2016 In ... a series of free workshops across ... requirements for Good Distribution Practices (GDP). Good ... ensures that products are consistently stored, transported and handled ... (MA) or product specification. Only a few years ago, ...
(Date:5/4/2016)... 2016 Research and ... Acute Myeloid Leukemia Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... and Competitive Landscape Highlights 2016, provides comprehensive ... Acute Myeloid Leukemia epidemiology, Acute Myeloid Leukemia ...
Breaking Medicine Technology: