Navigation Links
UBC researchers to lead $4.7-million study on early-stage oral cancer
Date:5/27/2011

Researchers from the University of British Columbia's Faculties of Medicine, Science and Dentistry are leading a $4.7-million pan-Canadian clinical trial aimed at improving outcomes for patients undergoing surgery for oral squamous cell cancers.

Funded by the Terry Fox Research Institute, the Canadian Optically Guided Approach for Oral Lesions Surgical Trial, or COOLS Study, involves universities and hospitals in nine Canadian cities. Findings from the study could revolutionize clinical practice here and around the world.

According to the Canadian Cancer Society, an estimated 3,400 Canadians are diagnosed with oral cancer every year. In 2010, the estimated number of deaths due to oral cancer was 1,150. Currently, about 30 per cent of patients who receive oral surgery have their cancer recur. The COOLS Study will investigate the effectiveness of a fluorescence visualization, or "blue light," to distinguish between healthy tissues from tumours or pre-cancerous cells in the mouth. Under the blue light, normal tissue generates a fluorescence which is absent in tumour or pre-cancerous tissue.

"In work we've conducted to date in Vancouver, there has been almost no recurrence where surgery followed the contour of the lesion shown by using FV-guided surgery. Working together with surgeons, pathologists, research staff and scientists, this TFRI-funded study will enable us to test the approach on a broader cohort of patients at sites across the country and obtain the evidence required to change current practice." says principal investigator Dr. Catherine Poh, a senior scientist with BC Cancer Agency, an associate professor at the UBC Faculty of Dentistry and a consulting dentist at Vancouver General Hospital.

"Our surgical community has expressed great interest in participating in this trial which provides an unique and important opportunity to assess a surgical intervention in a controlled prospective manner across many sites," says principal investigator Dr. Scott Durham, head of the division of otolaryngology at Vancouver General Hospital and a clinical professor at UBC's Faculty of Medicine. The study aims to build a network of clinicians, pathologists and research staff across the country to fight oral cancer.

"This study will have an immediate impact on practice if the study turns out the way we hope," says principal Investigator Dr. Miriam Rosin, a senior scientist with the BC Cancer Agency who holds joint appointments at UBC and Simon Fraser University. "If the study is successful, it will help to reduce the number of deaths from oral cancer as well as to improve the quality of life for people living with this disease. Working with scientists, we will have this new approach ready to disseminate to the surgical community at large and even globally."

The study's lead investigators also include Calum Macaulay, a clinical associate professor at the UBC Faculty of Medicine and an associate member in Medical Physics in the UBC Faculty of Science; and Stuart Peacock, an associate professor at UBC's School of Population and Public Health in the Faculty of Medicine.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related medicine news :

1. Researchers evaluate red wine compound for treating concussions in pro boxers
2. Researchers Find Cousin of Hepatitis C Virus in Dogs
3. Researchers discover link between obesity gene and breast cancer
4. Mount Sinai researchers discover possible new target for sarcoma treatment and prevention
5. Researchers connect electrical brain disturbances to worse outcomes following neurotrauma
6. Pitt researchers build a better mouse model to study depression
7. Researchers discover that lymphocyte count indicates prognosis of patients with renal cell carcinoma
8. Researchers home in on genetic signature of esophageal cancer
9. Legendary Hollywood directors and renowned researchers awarded 2011 Dan David Prizes
10. Columbia researchers work to prevent blindness from age-related macular degeneration
11. Hebrew University researchers show octopuses make some pretty good moves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, ... members and suppliers for its inaugural Member Conference at the Paris Hotel in ... elevating the operational health of America’s healthcare providers. , The conference was highlighted ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... a significant negative impact on long-term patient survival, reports a team of UPMC ... online this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found ... The 550 employees of Sun Health Senior Living (SHSL) may not share ... their doctor and prescription copays for the year, while holding the line on increasing ...
(Date:5/26/2016)... ... , ... The Lung Institute has partnered with the Gulfcoast North ... 6 at their clinic in downtown Tampa. The class is complimentary for the public. ... created a free downloadable 4 Week Smoking Cessation Guide for those who ...
(Date:5/26/2016)... ... May 26, 2016 , ... Eugene Batelli, ... Along with his wonderful accolades and stellar patient reviews, Dr. Batelli continues to ... , Dr. Eugene Batelli is a highly trained Podiatric Surgeon who specializes in ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 ReportsnReports.com adds "Chronic ... that provides an overview on therapeutic pipeline of ... stages, therapeutics assessment by drug target, mechanism of ... type, along with latest updates, and featured news ... involved in the therapeutic development for Chronic Cough ...
(Date:5/24/2016)... May 24, 2016 Cirujanos holandeses ... ayudar a los médicos a compartir sus mejores prácticas ... escala mundial. Profesionales médicos de Europa, África, ... apuntado a la aplicación, que combina la transmisión en ... totalmente seguro. Educación   "Imagine un ...
(Date:5/24/2016)...   , Study met ... and superiority in , Excellent plus ... of the ascending colon   , ... B.V. today announced new positive data from the phase III MORA ... standard 2 litre PEG with ascorbate. The study met both primary ...
Breaking Medicine Technology: