Navigation Links
UBC researchers discover 'instruction manual' that tells cancers how to hide from immune system
Date:11/8/2007

A mechanism that creates an invisibility cloak for certain cancer cells and allows them to hide from the immune system has been uncovered by a team of researchers at the University of British Columbia.

Prof. Wilfred Jefferies and his team found that metastatic tumours (cancers that spread from primary site) can evade the immune system via a process called chromatin remodeling. The invisibility mechanism operates in malignant carcinomas that include ovarian, prostate, melanoma and cervical cancers and is particularly active in breast and lung cancers.

This discovery begins to address the mysteries of how cancer hides from the immune system and spreads it helps explain 20 years of observations in the field, says Jefferies, a member of UBCs Michael Smith Laboratories and Biomedical Research Centre. It may offer whole new avenues for therapies.

Human DNA is packaged within each cell by chromatin, which is made up of DNA that encases proteins called histones. The UBC team discovered that in tumours, chromatin remodelling changes the structure of chromosomes by altering the histone codex or instruction manual. These changes reduce production of receptors called MHC I molecules that display cancer-specific signals, or tags, recognized by the immune system.

When cancer-specific tags are not displayed, the cancer cells become invisible to the immune system and no defenses are mobilized the tumour cells are free to grow and spread. Furthermore, the high incidence of MHC I loss can be used as a predictor of rapid tumour growth progression and survival rates.

The research has recently been published in Molecular and Cellular Biology. Jefferies is a UBC professor of Medical Genetics, Microbiology and Immunology and of Zoology.

Jefferies says the findings may lead, within five to 10 years, to new therapies that will force the cancer cells to drop the cloak of invisibility and be recognized by the immune system.


'/>"/>

Contact: hilary.thomson@ubc.ca
hilary.thomson@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Page: 1

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... from Sub-Saharan Africa, Latin America and Caribbean islands ... new research from St. Michael,s Hospital. , The ... of Obstetrics and Gynaecology , assessed the differences ... native-born women in six high-immigration countries Australia ... Valencia) and the United States (California, New Jersey ...
(Date:4/23/2014)... director at the National Institute of Arthritis and Musculoskeletal ... recipient of the Ross Prize in Molecular Medicine, conferred ... Medicine . The award will be given on June ... Manhattan, followed by scientific presentations by Dr. O,Shea and ... Institutes of Health. , The award, which includes a ...
(Date:4/23/2014)... report that rats exposed to high-energy particles, simulating conditions ... show lapses in attention and slower reaction times, even ... ranges. , The cognitive impairments which affected a ... appear to be linked to protein changes in ... to hold true in humans, suggest it may be ...
(Date:4/23/2014)... N.Y. A novel compound that targets an important ... of cocaine addiction behaviors, including relapse behavior, a University ... provides strong evidence that this may be a novel ... effective medications exist., The UB research was published as ... week. , In the study, the compound, RO5263397, severely ...
(Date:4/23/2014)... new computer program could help doctors predict which patients ... treatment. , The program, which assesses brain scans ... airport security and passport control, has been developed by ... study funded by the Wellcome Trust, which used the ... . , Stroke affects over 15 million people ...
Breaking Medicine News(10 mins):Health News:Pregnancy complications may be more common in immigrants from certain regions 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Some astronauts at risk for cognitive impairment, animal studies suggest 2Health News:Some astronauts at risk for cognitive impairment, animal studies suggest 3Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Airport security-style technology could help doctors decide on stroke treatment 2Health News:Airport security-style technology could help doctors decide on stroke treatment 3
... ... every year, 35 to 50 million Americans become infected with the flu (influenza). On average, ... Plano, TX is taking steps to combat these preventable deaths by offering free flu shots ... Plano, TX (Vocus) September 12, ...
... , , , ... important safety notice to its more than 750,000 subscribers of its ... wearing a "pendant" style help button. The service is used primarily ... at risk of falls. By pressing a "help button" worn on ...
... of Public Health has been awarded $18.4 million by ... U.S. Department of Defense to establish an Extremity Trauma ... the coordinating center for the Consortium that includes a ... with several major military treatment centers and the U.S. ...
... ... on the Failed War on Drugs , ... Las Vegas, NV (PRWEB) September 11, 2009 -- PAINWeek® 2009, the national conference ... drug reform in the United States as keynote speaker former Assistant US Attorney Jennifer Bolen, ...
... help predict who,s susceptible to the disease, study says , ... to a higher risk of Alzheimer,s disease seems to affect ... thought, new research suggests. , The brains of people in ... -- which boosts the risk of Alzheimer,s but doesn,t guarantee ...
... , NEW YORK, Sept. 11 Duane Reade Holdings ... that, as the Local Presenting Sponsor of the 2009 Komen New ... its foundation, The Duane Reade Charitable Foundation, have raised $330,000 to ... to find a cure. This marks the third year that Duane ...
Cached Medicine News:Health News:H1N1 frenzy may allow regular flu to be more deadly than ever 2Health News:Lifeline Issues Safety Notice to Subscribers 2Health News:JHSPH to lead extremity trauma clinical research consortium 2Health News:JHSPH to lead extremity trauma clinical research consortium 3Health News:Healthcare Legal Issues Take the Stage at PAINWeek 2009 2Health News:Healthcare Legal Issues Take the Stage at PAINWeek 2009 3Health News:Alzheimer's Gene Affects Brains of Young Adults 2Health News:New Yorkers Help Duane Reade Increase Support of the 19th Annual Komen New York City Race For The Cure(R) 2Health News:New Yorkers Help Duane Reade Increase Support of the 19th Annual Komen New York City Race For The Cure(R) 3
(Date:1/14/2014)... , Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ... the fourth quarter of 2013 on Monday, February 3, 2014. ... after the close of trading. (Logo: ... to discuss the operating highlights and financial results for the ...
(Date:1/14/2014)... 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company ... Progressive Home Medical Equipment, Inc. ("Progressive") of Clarion, ... the acquisition were not disclosed. Progressive is ... wide range of sleep, mobility, and respiratory products to customers ...
(Date:1/14/2014)... PLYMOUTH, Minn. , Jan. 14, 2014   NuAire , a ... come to agreement with Hitachi Koki of ... centrifuges in North America . NuAire will utilize ... and Canada to offer assistance ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... Be Presented --, SAN FRANCISCO, April 24, 2007 /PRNewswire-FirstCall/ ... Phase,2 efficacy study of Dimebon(TM) in Alzheimer's disease will ... at the American,Academy of Neurology's 59th Annual Meeting in ... The presentation will include new,data from both the mild ...
... WIRE)--Apr 24, 2007 - Ceragenix Pharmaceuticals,Inc. (OTCBB:CGXP) ... study comparing EpiCeram's(TM) efficacy to,that of Cutivate(R) ... of moderate-to-severe atopic dermatitis (AD)., The study, ... of 113,pediatric patients, with 59 patients receiving ...
Cached Medicine Technology:Medivation Announces First U.S. Presentation of Data From Dimebon,Phase 2 Alzheimer's Disease Trial at American Academy of Neurology,Annual Meeting 2Medivation Announces First U.S. Presentation of Data From Dimebon,Phase 2 Alzheimer's Disease Trial at American Academy of Neurology,Annual Meeting 3Ceragenix Announces Results from Phase IV Study of EpiCeram Meet,All Primary and Secondary Endpoints 2Ceragenix Announces Results from Phase IV Study of EpiCeram Meet,All Primary and Secondary Endpoints 3Ceragenix Announces Results from Phase IV Study of EpiCeram Meet,All Primary and Secondary Endpoints 4Ceragenix Announces Results from Phase IV Study of EpiCeram Meet,All Primary and Secondary Endpoints 5Ceragenix Announces Results from Phase IV Study of EpiCeram Meet,All Primary and Secondary Endpoints 6
... of Hemoglobin S in patient samples. Each ... and 20l of anticoagulated whole blood or ... test kit contains two bottles of phosphate ... and two vials of Sodium Hydrosulfite reagent ...
... CD-Chex Plus BC is an assayed control ... systems. CD-Chex Plus BC determines the accuracy ... in the process of immunophenotyping, including red ... subsets of leukocytes include: T lymphocytes, B ...
Streck-T-Pack is specially designed for use on Coulter® Counter T Series instruments. Each convenient pack includes diluent, lysing agent and enzymatic cleanser. The shelf life is 18 months from ...
... CD-Chex CD34 is a ... leukocytes which can be used ... when evaluating CD34 positive cells. ... ISHAGE and ProCOUNT gating strategies. ...
Medicine Products: