Navigation Links
UAlberta medical researchers make key discovery in fight against Alzheimer's disease
Date:12/11/2012

Medical researchers at the University of Alberta have discovered a drug intended for diabetes appears to restore memory in Alzheimer's brain cells.

Jack Jhamandas, a researcher with the Faculty of Medicine & Dentistry at the U of A, is the principal investigator with the team whose research results were recently published in the peer-reviewed publication The Journal of Neuroscience. He works in the Division of Neurology.

The team took brain tissue from animal models with Alzheimer's disease and tested the tissue in the lab, looking specifically at the cells' memory capacity. When brain cells are shocked by a barrage of electrical impulses, the cells "remember" the experience and this is a typical way to test or measure memory in the lab setting.

Amyloid protein, which is found in abnormally large amounts in the memory and cognition parts of the brains of Alzheimer's patients, diminishes memory. A sister protein, known as amylin, which comes from the pancreas of diabetic patients, has the same impact on memory cells.

Jhamandas and his team demonstrated last year that a diabetes drug that never made it to market, known as AC253, could block the toxic effects of amyloid protein that lead to brain cell death.

In the lab, Jhamandas and his teammates, which included Ryoichi Kimura, a visiting scientist from Japan, tested the memory of normal brain cells and those with Alzheimer'sboth from animal models. When the drug AC253 was given to brain cells with Alzheimer's and the shock memory tests were redone, memory was restored to levels similar to those in normal cells.

"This is very important because it tells us that drugs like this might be able to restore memory, even after Alzheimer's disease may have set in," says Jhamandas.

His team is continuing their research in this area and wants to see if the drug, when given before symptoms appear, can "stop the impairment of behaviour and cognition altoget
'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UAlberta prostate cancer researcher and team developing homing beacon drugs to target cancer cells
2. Porcupine Quill Could Foster New Medical Devices
3. US Drug Watchdog Now Offers Women Who Are Victims Of A Transvaginal Mesh, Sling, or Tape Medical Product Failure the Names of The Best Possible Lawyers-Who are All Women
4. PsychiatristSites (Websites for Psychiatrists) Announces Partnership with Medical Billing Professionals
5. QuickMedical Announces Successful Sales and Marketing Results for 2012
6. Cost Per Workers’ Compensation Claim Rising In Indiana As Payments for Medical Care Increase, Says New WCRI Study
7. The greatest medical resource youve never heard of: Rochester epidemiology project
8. Survey shows breakthrough medical research relies heavily on NIH funding
9. DXE Medical, Inc. Donates to Franklin Firefighters Annual Christmas Toy and Clothing Drive
10. TherapySites (Websites for Therapists) Announces Partnership with Medical Billing Professionals
11. ISA Surgical Publishes Real Stories of the Benefits of Medical Tourism In Mexico From US And Canadian Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... BellasDress.com offers a wide range of women’s ... announces its BellasDress Christmas Sale , offering big ... , BellasDress is a famous online supplier of women’s ... a series of promotions. The dress experts of the ... “We are proud of offering high quality wedding dresses ...
(Date:12/21/2014)... HealthDay Reporter FRIDAY, Dec. 19, 2014 ... than traditional cigarettes, new research finds. Even though ... thousands of ex-smokers said they have fewer cravings and are ... to smoke, researchers reported. "The pattern was ... use than for tobacco use," said lead researcher Jonathan Foulds, ...
(Date:12/21/2014)... AZ (PRWEB) December 21, 2014 Parker ... range of heating, cooling, plumbing and other similar home ... in 2014 with regard to its expert contracting services. ... industry leader that has been serving Arizona for well ... in providing the absolute best in quality customer service ...
(Date:12/21/2014)... CannabisClassifieds.com celebrates marijuana’s new legal place at the ... its kind, the site has provided its faithful users with ... running. It uniquely combines the benefits of platforms like ... to the masses. Assuring the potent herb’s followers it’s ... public approval. , Shane Chattin, Owner of Cannabis ...
(Date:12/20/2014)... (PRWEB) December 21, 2014 MissyDress, a ... for all prom lovers. The business has drastically cut ... prom dresses to everyone until Jan. 30, 2015. Many ... dresses, sweetheart dresses, V-neck dresses, lace dresses, and more. ... are not there every day. Whether A-line princess prom ...
Breaking Medicine News(10 mins):Health News:BellasDress.com Announces its BellasDress Christmas Sale 2Health News:E-Cigarettes Less Addictive Than Regular Cigarettes, Study Finds 2Health News:E-Cigarettes Less Addictive Than Regular Cigarettes, Study Finds 3Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 3Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2
... shed no light on reason for link, Scottish researchers say ... twice as likely to suffer retinal detachment as poorer people, ... reason for the disparity. , Retinal detachment -- the separation ... the eye -- usually occurs as a result of a ...
... blood sugar values if this leads to improvements in ... Nauck of the Bad Lauterberg Diabetes Center and his ... International (Dtsch Arztebl Int 2009; 106[37]: 587-94), who ... On the basis of their analysis, the authors make ...
... link between thiazolidinediones and bone fractures, researchers say , MONDAY, ... drugs known as thiazolidinediones may be at higher risk of ... Ian Douglas of the London School of Hygiene and Tropical ... million patients in the United Kingdom and found 1,819 people ...
... ... a report based on its research into America’s Most Productive Companies. This companion ... Strategic and Operational Attributes of America’s Most Productive Companies. One of the key People ... ...
... ... a leading supplier of industrial products, has added over 20,000 apparel ... ReidSupply.com will save customers time and money by offering a new ... including flame-resistant and high-visibility clothing by Carhartt and others, as well ...
... ... Dads ( http://www.bcnd.org ), a non-profit orientation program for fathers-to-be, operating in more than ... a Master Coach Certification Training session October 2-3, 2009. , ... Irvine, CA and Denver, CO (Vocus) September 29, 2009 ...
Cached Medicine News:Health News:More Retinal Detachment Seen With Higher Income Status 2Health News:Profiles International Finds High Employee Utilization is One Key to Maximizing Productivity 2Health News:Profiles International Finds High Employee Utilization is One Key to Maximizing Productivity 3Health News:Reid Supply Adds Over 20,000 New Products Online 2Health News:Reid Supply Adds Over 20,000 New Products Online 3Health News:Boot Camp for New Dads to Hold Master Coach Certification Training in Denver October 2-3, 2009 2Health News:Boot Camp for New Dads to Hold Master Coach Certification Training in Denver October 2-3, 2009 3
(Date:12/17/2014)... Revenue and earnings above the previous year - ... In the past 2013/14 fiscal year (ended 30 September ... 4.287 billion (last year: EUR 4.190 billion) despite unfavorable currency ... million. "Overall, 2013/14 was a successful fiscal year for the ... CEO of Carl Zeiss AG. "Thanks to our broad portfolio ...
(Date:12/17/2014)... , Dec. 17, 2014 With ... (MRI), the MRI market is seeing new growth, ... breast MRI scans account for the majority of ... higher resolution of images, which are creating opportunities for ... (MRI) market is growing at a rate of ...
(Date:12/17/2014)... 17, 2014  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE ... Trademark Office (USPTO) has issued a key patent ... immunotherapeutic vaccine targeting six tumor antigens that are ... Patent No. 8,871,211, which issued October 28, 2014, ... a dendritic cell composition comprising peptide epitopes of ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... 2011 Actavis Group, the international generic pharmaceuticals company, today ... a binding letter of intent (LOI) with QRxPharma Limited (ASX: ... United States.  Under the terms of the ... IR, a patented 3:2 ratio fixed dose combination of morphine ...
...  QRxPharma Limited (ASX: QRX and OTCQX: QRXPY) announced today execution ... for the formation of a strategic partnership to commercialise MoxDuo ... IR is a patented 3:2 ratio fixed dose combination of ... Group, hf a privately held company based in Europe with ...
Cached Medicine Technology:Actavis to Launch Novel Pain Medication in the US 2Actavis to Launch Novel Pain Medication in the US 3QRxPharma Announces Strategic Partnership with Actavis 2QRxPharma Announces Strategic Partnership with Actavis 3QRxPharma Announces Strategic Partnership with Actavis 4QRxPharma Announces Strategic Partnership with Actavis 5
0.2 mm hook with curved shaft to reach over lens optic. Flat serrated handle with polished finish. Overall length: 4.8 inches. Most popular size or model....
0.2 mm, 90o angled tip with curved 9 mm shaft. Flat smooth handle with polished finish. Overall length: 4.5 inches....
Angled 45 degrees, 10 mm shaft with 0.2 mm tip. Round knurled handle with dull finish. Overall length: 4.6 inches....
2.0 mm cup. Angled 45 degree shaft 8 mm from tip to bend with flat handle and polished finish. Overall length: 4.8 inches....
Medicine Products: