Navigation Links
UAlberta medical researchers discover new potential chemotherapy
Date:12/13/2012

Medical researchers at the University of Alberta have discovered that knocking out a particular "partner" gene is the Achilles' heel of some cancers.

Cancer causing genes often have a partner in crime, meaning when either of the two genes is active in cancer cells, the tumour grows. The challenge for researchers has been pinpointing the genes lethal partners. Loss of one of the partners alone isnt deadly to the cell, but if both are gotten rid of, the cancer cells are destroyed.

Faculty of Medicine & Dentistry researcher Michael Weinfeld and his collaborators, Edan Foley and graduate student Todd Mereniuk, took cells and artificially removed a particular gene known as PKNP. Then the team knocked out 7,000 other genes, one at a time, all in an effort to find PKNP's "lethal partners" that trigger cell death.

And the team found ita deadly partner gene, a rare type of cancer suppressor typically missing in lymphomas.

The team confirmed their findings by examining tumours that lacked this specific cancer suppressor. They then inactivated PKNP, which caused the cancer cells to die. Their findings were published in the peer-reviewed journal Cancer Research.

Developing cancer drugs that inactivate PKNP will result in only the cancer cells that lack this gene being eradicated, not healthy, normal cells, says Weinfield, who works in the Department of Oncology at the U of A.

"Lots of work in the cancer research field is to try and come up with ways to attack cancer cells and leave normal cells intact," he says. "You need to take advantage of whatever you can to defeat cancer, which can be extremely difficult."

Weinfeld and his colleagues are now working with Dennis Hall in the Department of Chemistry at the U of A and the Centre for Drug Research and Development in British Columbia to improve this potential drug they've discovered. They are also partnering with John Lewis, the Frank and Carla Sojonky Chair in Prostate Cancer Research in the Faculty of Medicine & Dentistry, to work with his cancer-targeting nanotechnology theories.


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related medicine news :

1. UAlberta prostate cancer researcher and team developing homing beacon drugs to target cancer cells
2. UAlberta medical researchers make key discovery in fight against Alzheimers disease
3. Physician Groups Call for Fewer Medical Tests
4. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
5. CAM therapy combined with conventional medical care may improve treatment of lower back pain
6. Image share project gives patients and physicians anytime, anywhere access to medical images
7. Researchers determine vitamin D blood level for reducing major medical risks in older adults
8. Biomedical researchers receive Hartwell Foundation awards
9. Columbia University Medical Center and NY-Presbyterian experts at APA meeting
10. Fitness in Middle Age Lowers Medical Costs Later: Study
11. Ben-Gurion U. and Cincinnati Childrens Hospital to develop pediatric-specific medical technologies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... (PRWEB) , ... May 21, 2017 , ... ... if it's been longer than six months since you've seen a dentist, it's ... twice per year and getting x-rays once per year. , Dental checkups are ...
(Date:5/19/2017)... ... May 19, 2017 , ... When Kyle Busch graduates from ... will already appear on two major research studies that could impact the health of ... Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an international team trying to ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Arnold ... Young Investigators: , Victor Acosta, Ph.D. - University of New Mexico, Jeremy Baskin, ... - University of Washington, Erik Grumstrup, Ph.D. - Montana Stata University, A. Fatih ...
(Date:5/19/2017)... ... 2017 , ... CloSYS products which are marketed as the gentle giants of ... and gum health, which is linked to one’s overall health. Since 1991 when the ... powerful ways in which CloSYS products immediately helped eliminate bad breath as well as ...
(Date:5/18/2017)... ... ... Originally launched to market as the EPIK Learning Tab, the highly successful ... of their product line, the company believed it was the right time to create ... be any tablet product sold by EPIK Learning. This year there will be ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... 15, 2017 Enterin Inc., a privately-held CNS pharmaceutical ... novel compounds to treat Parkinson,s disease (PD), has enrolled the ... Phase 1/2a randomized, controlled, multicenter study involving patients with PD ... 50 patients over a 9-to-12-month period. The first stage is ... with PD. Participating sites include Denver , ...
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
Breaking Medicine Technology: