Navigation Links
UAB study examines hearing loss, Viagra use
Date:5/18/2010

BIRMINGHAM, Ala. Research by a University of Alabama at Birmingham (UAB) professor shows an association between hearing loss and the use of the erectile dysfunction drug Viagra.

Findings published May 18 in Archives of Otolaryngology-Head and Neck Surgery indicate a potential for long-term hearing loss following use of Viagra, and possibly following use of other phosphodiesterase type 5 inhibitors (PDE-5i) drugs such as Cialis and Levitra, although results on those drugs are inconclusive.

"It appears from these findings that the current government warning regarding hearing loss and the use of PDE-5i medications is warranted," said study author Gerald McGwin, Ph.D., a professor of epidemiology in the UAB School of Public Health. "Though there are limitations to this study, it is prudent that patients using these medications be warned about the signs and symptoms of hearing impairment and be encouraged to seek immediate medical attention to potentially forestall permanent damage."

In 2007, following the report of several case studies potentially linking PDE-5i use and sudden hearing loss, the Food and Drug Administration announced labeling changes for PDE-5i medications so that the risk of hearing problems was more prominently displayed. McGwin said this is the first epidemiologic study to evaluate the relationship between PDE-5i drugs and long-term hearing loss.

McGwin examined data on 11,525 men over 40 years of age gathered by the Medical Expenditure Panel Survey, a survey conducted by the federal Agency for Healthcare Research and Quality between 2003 and 2006. Men who reported use of PDE-5i medications were twice as likely to also report hearing loss as were men who had not used the drugs.

McGwin said the relationship was strongest for men reporting use of sildenafil (Viagra) over those who used tadalafil (Cialis) or vardenafil (Levitra), a finding he attributed in part to a small sample size for both of the latter drugs. McGwin said the findings indicated an elevated but not statistically significant increase in hearing loss for users of tadalafil and vardenafil.

PDE-5i drugs were originally designed to treat pulmonary hypertension and are now used extensively in the treatment of erectile dysfunction (ED). McGwin said one important consideration in evaluating the nature of the relationship between the drugs and hearing is the existence of a plausible biological mechanism of how these drugs might cause hearing loss.

"PDE-5i medications work in ED patients by their ability to increase blood flow to certain tissues in the body," said McGwin. "It has been hypothesized that they may have a similar effect on similar tissues in the ear, where an increase of blood flow could potentially cause damage leading to hearing loss."

McGwin acknowledged limitations in the study, including the limited sample size for tadalafil and vardenafil, concerns over under-reporting of use of PDE-5i medications and confounding factors such as pre-existing conditions that might also contribute to hearing loss. He suggested that additional research regarding the risk from PDE-5i is necessary due to the largely irreversible nature of hearing loss and its impact on quality of life.

"The results of the current study in conjunction with a plausible biologic mechanism lend support to the FDA's decision to warn patients about the potential risk posed by PDE-5i use," he said.


'/>"/>

Contact: Bob Shepard
bshep@uab.edu
205-934-8934
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Study finds 2 sling surgeries equally effective for bladder control in women
2. Newborn infants learn while asleep; study may lead to later disability tests
3. Worlds biggest study on cell phones and brain cancer inconclusive
4. Varicose vein study shows radiofrequency ablation causes less post-operative pain
5. Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved
6. Lifestyle factors significantly impact survival of non-Hodgkins lymphoma patients, study finds
7. Study identifies 1 of the mechanisms behind breast cancer metastasis
8. Study shows costs and benefits of testosterone in birds
9. Study finds rotavirus vaccine greatly reduces hospitalizations for acute gastroenteritis in children
10. Childhood psychological problems create long-term economic losses, study finds
11. HIRC Research Alert: New Study Identifies Best Pharmaceutical Company Account Managers and Program Offerings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! God’s Gift: A ... their parents and God. “Congratulations! It's A Boy! God’s Gift: A Story of Love” ... Long Island, New York. , Published by Christian Faith Publishing, Dale Anthony and Rachael ...
(Date:8/18/2017)... Lynchburg, VA (PRWEB) , ... August 18, 2017 , ... ... to the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined ... as well as the generous support of the Liberty community. These shoes will save ...
(Date:8/18/2017)... York (PRWEB) , ... August ... ... LLC, d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider ... has entered into a definitive agreement to purchase Unitrans International Corporation, a ...
(Date:8/18/2017)... New York, NY (PRWEB) , ... August 18, ... ... the launch of this summer’s edition of “Vision & Hearing,” advocating for active, ... The campaign focuses on resources available for individuals with hearing impairments and shares ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... liquid handling handheld devices. Through an educational webinar, they will present the line ... a chance to learn how easy you can automate everyday pipetting tasks. , ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... 2017  Opioid addiction and other drugs of abuse, ... and threatening outcomes, were problems taken on directly as ... that support them, met this week. This according to ... drugs of abuse, procalcitonin and acute kidney injury were ... 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... -- Life Flight Network and PeaceHealth Oregon Network announced they renewed ... operational efficiency for patients at hospitals in Eugene ... Grove , and Florence, Oregon , ... Network work collaboratively to move patients who require the highest ... sensitive emergency exists. ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
Breaking Medicine Technology: